{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:59:36Z","timestamp":1780646376218,"version":"3.54.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Aesthetic treatment of the lower face is increasingly in demand, particularly owing to age-related changes in appearance. VYC-25L is a novel hyaluronic acid filler with high G\u2032 and high cohesivity, specifically designed for sculpting and contouring of the chin and jaw.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this study was to assess the use of a grid traced onto the chin and jaw for guiding treatment with VYC-25L.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective, single-center analysis of data from adult patients undergoing treatment of the lower third of the face with VYC-25L. A grid system of horizontal and vertical lines was used to systematize the process of treatment planning and performance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thirty subjects were enrolled (53.3% female; mean [standard deviation] age, 34.4\u2005[2.8] years). The mean quantity of VYC-25L used was 4.0\u2005[0.8] mL. Based on the 5-point Global Aesthetic Improvement Scale, 29 patients (96.7%) rated their appearance at 20 days posttreatment as \u201cmuch improved\u201d or \u201cvery much improved.\u201d The only complications recorded were early transient soft-tissue edema (n\u2005=\u200514; 46.7%) and bruising (n\u2005=\u20056; 20.0%). There were no cases of infection, paresthesia, asymmetry, hematoma, necrosis, or skin discoloration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Treatment of the chin and jawline with VYC-25L, with injection locations determined by a standardized grid-based approach, appears to be effective and safe with high rates of patient satisfaction. Injection of this filler offers a potentially high-impact approach for patients across a variety of biological and economic circumstances.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Level of Evidence: 4<\/jats:title>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/asj\/sjaa179","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T23:13:51Z","timestamp":1593299631000},"page":"1068-1076","source":"Crossref","is-referenced-by-count":39,"title":["Nonsurgical Redefinition of the Chin and Jawline of Younger Adults With a Hyaluronic Acid Filler: Results Evaluated With a Grid System Approach"],"prefix":"10.1093","volume":"41","author":[{"given":"Dario","family":"Bertossi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University of Verona, Policlinico G.B. Rossi , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Robiony","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University of Udine, Academic Hospital of Udine , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lazzarotto","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University of Udine, Academic Hospital of Udine , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Giampaoli","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University of Verona, Policlinico G.B. Rossi , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5086-4390","authenticated-orcid":false,"given":"Riccardo","family":"Nocini","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University of Verona, Policlinico G.B. Rossi , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Francesco","family":"Nocini","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University of Verona, Policlinico G.B. 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