{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:15:58Z","timestamp":1791915358012,"version":"4.3.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100007307","name":"Arthrex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007307","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lipofilling has become popular as a treatment to improve aging-related skin characteristics (eg, wrinkles, pigmentation spots, pores, or rosacea). Different additives such as platelet-rich plasma (PRP) or stromal vascular fraction (SVF) have been combined with lipofilling to increase the therapeutic effect of adipose-derived stromal cells (ASCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to examine the hypothesis that mechanically isolated SVF augments the therapeutic effect of PRP-supplemented lipofilling to improve facial skin quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, double-blind, placebo-controlled, randomized trial was conducted between 2016 and 2019. In total, 28 female subjects were enrolled; 25 completed the follow-up. All patients received PRP-supplemented lipofilling with either mechanically isolated SVF or saline. SVF was isolated by fractionation of adipose tissue (tSVF). Results were evaluated by changes in skin elasticity and transepidermal water loss, changes in skin-aging-related features, ie, superficial spots, wrinkles, skin texture, pores, vascularity, and pigmentation, as well as patient satisfaction (FACE-Q), recovery, and number of complications up to 1 year postoperative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The addition of tSVF to PRP-supplemented lipofilling did not improve skin elasticity, transepidermal water loss, or skin-aging-related features. No improvement in patient satisfaction with overall facial appearance or facial skin quality was seen when tSVF was added to PRP-supplemented lipofilling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In comparison to PRP-supplemented lipofilling, PRP-supplemented lipofilling combined with tSVF does not improve facial skin quality or patient satisfaction in a healthy population. PRP-supplemented lipofilling combined with tSVF can be considered a safe procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence: 2<\/jats:title>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/asj\/sjab109","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T08:27:34Z","timestamp":1615278454000},"page":"NP1000-NP1013","source":"Crossref","is-referenced-by-count":17,"title":["The Addition of Tissue Stromal Vascular Fraction to Platelet-Rich Plasma Supplemented Lipofilling Does Not Improve Facial Skin Quality: A Prospective Randomized Clinical Trial"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-9568","authenticated-orcid":false,"given":"Joris A","family":"van Dongen","sequence":"first","affiliation":[{"name":"University Medical Center Utrecht , Utrecht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joeri V","family":"Boxtel","sequence":"additional","affiliation":[{"name":"Catharina Hospital Eindhoven , Eindhoven , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joep C","family":"Willemsen","sequence":"additional","affiliation":[{"name":"Albert Schweitzer Hospital Dordrecht , Dordrecht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University of Groningen and University Medical Center of Groningen , Groningen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin M","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Groningen and University Medical Center of Groningen , Groningen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aartje Jorien","family":"Tuin","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University of Groningen and University Medical Center of Groningen , Groningen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7128-2741","authenticated-orcid":false,"given":"Martin C","family":"Harmsen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University of Groningen and University Medical Center of Groningen , Groningen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berend","family":"van der Lei","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, University of Groningen and University Medical Center of Groningen , Groningen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hieronymus P","family":"Stevens","sequence":"additional","affiliation":[{"name":"plastic surgeon in private practice in Rotterdam , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"issue":"5","key":"2022112818203458000_CIT0001","doi-asserted-by":"crossref","first-page":"784e","DOI":"10.1097\/PRS.0000000000006147","article-title":"The effects of facial lipografting on skin quality: a systematic review","volume":"144","author":"van Dongen","year":"2019","journal-title":"Plast Reconstr Surg."},{"issue":"8","key":"2022112818203458000_CIT0002","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1089\/scd.2011.0200","article-title":"The tunica adventitia of human arteries and veins as a source of mesenchymal stem cells","volume":"21","author":"Corselli","year":"2012","journal-title":"Stem Cells Dev."},{"issue":"6","key":"2022112818203458000_CIT0003","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1089\/scd.2008.0117","article-title":"Defining stem and progenitor cells within adipose tissue","volume":"17","author":"Lin","year":"2008","journal-title":"Stem Cells Dev."},{"issue":"14","key":"2022112818203458000_CIT0004","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1089\/scd.2011.0722","article-title":"Same or not the same? 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