{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:45:44Z","timestamp":1793249144921,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Managing acne scars is a challenge and therapies are divided into nonsurgical and surgical. Highly Purified Technology Polynucleotides (PN-HPT) is a compound that contains a mixture of DNA polymers of different lengths. Numerous studies have shown that PN-HPT also serves as an energy source, thus influencing cellular growth and cell vitality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The authors aimed to assess the improvement in dermal quality and acne scars after PN-HPT vs placebo according to Antera 3D and the patient responses to the patient satisfaction questionnaire after a comparison of pretreatment and posttreatment photographs at 1 and 3 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Included were women aged 30 to 50 years with grade 3 to 4 moderate-to-severe atrophic scars according to the Goodman classification; nonsmokers; and had not had active acne during the past 5 years. Ten patients (PN-HPT group) were treated with 4.0 mL of PN-HPT, and 10 patients (control) were treated with 4.0 mL of normal saline. All medical treatments were performed in a double-blinded manner; neither the injection doctor nor the patient knew if the PN-HPT or the placebo was being administered.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty women who fit the inclusion criteria were enrolled in this study. Only patients in the PN-HPT group improved significantly at 1 and 3 months after treatment compared with baseline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This prospective and randomized study showed that PN-HPT in monotherapy was safe and effective treatment for atrophic scar acne compared with placebo. Prospective and randomized studies will be necessary to investigate the clinical effectiveness in a larger cohort of patients and for a longer follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Level of Evidence: 2<\/jats:title>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/asj\/sjab125","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T09:46:23Z","timestamp":1616492783000},"page":"NP866-NP874","source":"Crossref","is-referenced-by-count":34,"title":["Preliminary Prospective and Randomized Study of Highly Purified Polynucleotide vs Placebo in Treatment of Moderate to Severe Acne Scars"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4177-9976","authenticated-orcid":false,"given":"Antonino","family":"Araco","sequence":"first","affiliation":[{"name":"Department of Aesthetic Medicine, University Tor Vergata of Roma , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Araco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"issue":"9","key":"2022112918402723300_CIT0001","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1038\/jid.2009.47","article-title":"Prevalence, severity, and severity risk factors of acne in high school pupils: a community-based study","volume":"129","author":"Ghodsi","year":"2009","journal-title":"J Invest Dermatol"},{"issue":"5","key":"2022112918402723300_CIT0002","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2165\/00128071-200607050-00002","article-title":"Persistent acne in women: implications for the patient and for therapy","volume":"7","author":"Williams","year":"2006","journal-title":"Am J Clin Dermatol"},{"issue":"4","key":"2022112918402723300_CIT0003","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2230.1994.tb01200.x","article-title":"A clinical evaluation of acne scarring and its incidence","volume":"19","author":"Layton","year":"1994","journal-title":"Clin Exp Dermatol"},{"key":"2022112918402723300_CIT0004","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s40257-017-0321-x","article-title":"Acne scars: how do we grade them?","volume":"19","author":"Clark","year":"2018","journal-title":"Am J Clin Dermatol"},{"key":"2022112918402723300_CIT0005","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/DSS.0000000000001765","article-title":"A review and update of treatment options using the acne scar classification system","volume":"45","author":"Boen","year":"2019","journal-title":"Dermatol Surg"},{"issue":"12","key":"2022112918402723300_CIT0006","first-page":"1458","article-title":"Postacne scarring: a qualitative global scarring grading system","volume":"32","author":"Goodman","year":"2006","journal-title":"Dermatol Surg"},{"issue":"5","key":"2022112918402723300_CIT0007","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1001\/jamadermatol.2020.0135","article-title":"Evaluation of point-of-care decision support for adult acne treatment by primary care clinicians","volume":"156","author":"Li","year":"2020","journal-title":"JAMA Dermatol"},{"key":"2022112918402723300_CIT0008","first-page":"1","article-title":"Assessing adherence to evidence-based guidelines of care for acne vulgaris","author":"Dunaway","year":"2020","journal-title":"J Dermatolog Treat"},{"issue":"3","key":"2022112918402723300_CIT0009","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.3928\/19382359-20200211-01","article-title":"Acne vulgaris: treatment made easy for the primary care physician","volume":"49","author":"Berry","year":"2020","journal-title":"Pediatr Ann"},{"issue":"7","key":"2022112918402723300_CIT0010","first-page":"34","article-title":"Acne management guidelines by the Dermatological Society of Singapore","volume":"12","author":"Oon","year":"2019","journal-title":"J Clin Aesthet Dermatol"},{"key":"2022112918402723300_CIT0011","first-page":"14","article-title":"Efficacy of isotretinoin and antihistamine versus isotretinoin alone in the treatment of moderate to severe acne: a randomised control trial","volume":"17","author":"Pandey","year":"2019","journal-title":"Kathmandu Univ Med J"},{"key":"2022112918402723300_CIT0012","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s40257-019-00454-6","article-title":"Long-term effectiveness and safety of up to 48 weeks' treatment with topical adapalene 0.3%\/benzoyl peroxide 2.5% gel in the prevention and reduction of atrophic acne scars in moderate and severe facial acne","volume":"20","author":"Dr\u00e9no","year":"2019","journal-title":"Am J Clin Dermatol"},{"key":"2022112918402723300_CIT0013","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/DSS.0000000000000606","article-title":"Comparative study of the use of trichloroacetic acid and phenolic acid in the treatment of atrophic-type acne scars","volume":"42","author":"Dalpizzol","year":"2016","journal-title":"Dermatol Surg"},{"issue":"1","key":"2022112918402723300_CIT0014","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/DSS.0000000000002020","article-title":"Microneedling as a treatment for acne scarring: a systematic review","volume":"46","author":"Mujahid","year":"2020","journal-title":"Dermatol Surg"},{"issue":"2","key":"2022112918402723300_CIT0015","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/PRS.0000000000006462","article-title":"Microneedling of scars: a large prospective study with long-term follow-up","volume":"145","author":"Alster","year":"2020","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"2022112918402723300_CIT0016","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s12663-018-1155-7","article-title":"Clinical evaluation of microneedling therapy in the management of facial scar: a prospective randomized study","volume":"18","author":"Bandral","year":"2019","journal-title":"J Maxillofac Oral Surg"},{"issue":"6","key":"2022112918402723300_CIT0017","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1097\/DSS.0000000000002175","article-title":"Combination therapy of microneedle fractional radiofrequency and topical poly-lactic acid for acne scars: a randomized controlled split-face study","volume":"46","author":"An","year":"2019","journal-title":"Dermatol Surg"},{"issue":"5","key":"2022112918402723300_CIT0018","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/lsm.23151","article-title":"Efficacy and safety of ablative resurfacing with a high-energy 1064 Nd-YAG picosecond-domain laser for the treatment of facial acne scars in Asians","volume":"52","author":"Dai","year":"2019","journal-title":"Lasers Surg Med"},{"issue":"6","key":"2022112918402723300_CIT0019","doi-asserted-by":"crossref","first-page":"e13084","DOI":"10.1111\/dth.13084","article-title":"The efficacy of fractional ablative carbon dioxide laser combined with other therapies in acne scars","volume":"32","author":"Mu","year":"2019","journal-title":"Dermatol Ther"},{"issue":"2","key":"2022112918402723300_CIT0020","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/JCAS.JCAS_171_18","article-title":"Fractional carbon dioxide laser: optimizing treatment outcomes for pigmented atrophic acne scars in skin of color","volume":"12","author":"Arsiwala","year":"2019","journal-title":"J Cutan Aesthet Surg"},{"issue":"8","key":"2022112918402723300_CIT0021","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/lsm.23218","article-title":"Prospective study of fractionated dual-wavelength picosecond laser in treating acne scar","volume":"52","author":"Yang","year":"2020","journal-title":"Lasers Surg Med"},{"issue":"3","key":"2022112918402723300_CIT0022","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s10103-019-02891-5","article-title":"Comparison of fractional neodymium-doped yttrium aluminum garnet (Nd:YAG) 1064-nm picosecond laser and fractional 1550-nm erbium fiber laser in facial acne scar treatment","volume":"35","author":"Chayavichitsilp","year":"2020","journal-title":"Lasers Med Sci"},{"issue":"2","key":"2022112918402723300_CIT0023","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/lsm.23177","article-title":"Evaluation of the safety and efficacy of a picosecond alexandrite laser with DLA for acne scars in Chinese patients","volume":"52","author":"Zhang","year":"2020","journal-title":"Lasers Surg Med"},{"key":"2022112918402723300_CIT0024","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2147\/CCID.S188586","article-title":"Skin physiology and safety of microfocused ultrasound with visualization for improving skin laxity","volume":"14","author":"Kerscher","year":"2019","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2022112918402723300_CIT0025","doi-asserted-by":"crossref","first-page":"S190","DOI":"10.1097\/DSS.0000000000000228","article-title":"Safety and efficacy of combining microfocused ultrasound with fractional CO2 laser resurfacing for lifting and tightening the face and neck","volume":"40","author":"Woodward","year":"2014","journal-title":"Dermatol Surg"},{"issue":"5","key":"2022112918402723300_CIT0026","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/jocd.13308","article-title":"Subcision: indications, adverse reactions, and pearls","volume":"19","author":"Dadkhahfar","year":"2020","journal-title":"J Cosmet Dermatol"},{"issue":"1","key":"2022112918402723300_CIT0027","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/srt.12761","article-title":"Comparing cannula-based subcision with the common needle method: a clinical trial","volume":"26","author":"Nilforoushzadeh","year":"2020","journal-title":"Skin Res Technol"},{"issue":"8","key":"2022112918402723300_CIT0028","first-page":"18","article-title":"Subcision and microneedling as an inexpensive and safe combination to treat atrophic acne scars in dark skin: a prospective study of 45 patients at a tertiary care center","volume":"12","author":"Bhargava","year":"2019","journal-title":"J Clin Aesthet Dermatol"},{"issue":"4","key":"2022112918402723300_CIT0029","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/jocd.13331","article-title":"Platelet-rich plasma in noninvasive procedures for atrophic acne scars: a systematic review and meta-analysis","volume":"19","author":"Long","year":"2020","journal-title":"J Cosmet Dermatol"},{"issue":"6","key":"2022112918402723300_CIT0030","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s00266-019-01471-w","article-title":"A meta-analysis of the evidence for assisted therapy with platelet-rich plasma for atrophic acne scars","volume":"43","author":"Hsieh","year":"2019","journal-title":"Aesthetic Plast Surg"},{"issue":"3","key":"2022112918402723300_CIT0031","first-page":"207","article-title":"Split-face comparative study of microneedling with platelet-rich plasma versus microneedling alone in treating acne scars","volume":"17","author":"Darmawan","year":"2019","journal-title":"Skinmed"},{"issue":"4","key":"2022112918402723300_CIT0032","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s13555-019-00318-1","article-title":"Fractional erbium-YAG laser and platelet-rich plasma as single or combined treatment for atrophic acne scars: a randomized clinical trial","volume":"9","author":"El-Taieb","year":"2019","journal-title":"Dermatol Ther (Heidelb)"},{"key":"2022112918402723300_CIT0033","first-page":"27","article-title":"Long chain polynucleotides gel and skin biorevitalization","volume":"3","author":"Cavallini","year":"2007","journal-title":"Int J Plast Dermatol"},{"issue":"3","key":"2022112918402723300_CIT0034","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/jocd.13679","article-title":"Trocchi, members of The Polynucleotides HPT\u2122 Priming Board, Italian College of the Aesthetic Medicine Scientific Societies)\u2014SIME, AGOR\u00c0, SIES consensus report on the use of PN-HPT\u2122 (Polynucleotide Highly Purified Technology) in aesthetic medicine","volume":"20","author":"Cavallini","year":"2020","journal-title":"J. Cosmet Dermatol"},{"issue":"2","key":"2022112918402723300_CIT0035","article-title":"Improving on laser: biorevitalization of stretch marks, the polynucleotides infiltrations combined with CO2 laser option","volume":"6","author":"Matera","year":"2020","journal-title":"Aesthet Med."},{"issue":"5","key":"2022112918402723300_CIT0036","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/iwj.12368","article-title":"Trophic effects of polynucleotides and hyaluronic acid in the healing of venous ulcers of the lower limbs: a clinical study","volume":"13","author":"De Caridi","year":"2016","journal-title":"Int Wound J"},{"key":"2022112918402723300_CIT0037","first-page":"2","article-title":"Biorevitalization of postmenopausal labia majora, the polynucleotide\/hyaluronic acid option","volume":"3","author":"Palmieri","year":"2019","journal-title":"Obstet Gynecol Rep"},{"key":"2022112918402723300_CIT0038","first-page":"543","article-title":"Intrarticular treatment of osteoarthropathy knee with polynucleotides: a pilot study with medium-term follow-up","volume":"27","author":"Saggini","year":"2013","journal-title":"J Biol Regul Homeost Agents"},{"issue":"5","key":"2022112918402723300_CIT0039","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/srt.12696","article-title":"New image analysis tool for facial pore characterization and assessment","volume":"25","author":"Dissanayake","year":"2019","journal-title":"Skin Res Technol"},{"key":"2022112918402723300_CIT0040","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/srt.12177","article-title":"A quantitative evaluation method using processed optical images and analysis of age-dependent changes on nasolabial lines","volume":"21","author":"Jang","year":"2015","journal-title":"Skin Res Technol"},{"issue":"1","key":"2022112918402723300_CIT0041","first-page":"20","article-title":"Quantitative evaluation of atrophic acne scars using 3D image analysis with reflected LED light skin","volume":"26","author":"Tanizaki","year":"2019","journal-title":"Res Technol"},{"issue":"1","key":"2022112918402723300_CIT0042","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/jocd.13472","article-title":"Prospective and randomized comparative study of calcium hydroxylapatite versus calcium hydroxylapatite plus HIFU in treatment of moderate to severe acne scars","volume":"20","author":"Araco","year":"2021","journal-title":"J Cosmet Dermatol."},{"issue":"11","key":"2022112918402723300_CIT0043","first-page":"1109","article-title":"Safety and effectiveness of microfocused ultrasound with visualization for the correction of moderate to severe atrophic acne scars","volume":"18","author":"Maas","year":"2019","journal-title":"J Drugs Dermatol"},{"issue":"5","key":"2022112918402723300_CIT0044","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/14764172.2017.1406606","article-title":"Combined use of microfocused ultrasound and a calcium hydroxylapatite dermal filler for treating atrophic acne scars: a pilot study","volume":"20","author":"Casabona","year":"2018","journal-title":"J Cosmet Laser Ther"}],"container-title":["Aesthetic Surgery Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/asj\/advance-article-pdf\/doi\/10.1093\/asj\/sjab125\/36577850\/sjab125.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/41\/7\/NP866\/47416491\/sjab125.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/41\/7\/NP866\/47416491\/sjab125.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T19:00:26Z","timestamp":1669748426000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/asj\/article\/41\/7\/NP866\/6168389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,11]]},"references-count":44,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,3,11]]},"published-print":{"date-parts":[[2021,6,14]]}},"URL":"https:\/\/doi.org\/10.1093\/asj\/sjab125","relation":{},"ISSN":["1090-820X","1527-330X"],"issn-type":[{"value":"1090-820X","type":"print"},{"value":"1527-330X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,7,1]]},"published":{"date-parts":[[2021,3,11]]}}}