{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:13:39Z","timestamp":1787008419504,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Youth Project of Heilongjiang Scientific Foundation, China","award":["QC2018102"],"award-info":[{"award-number":["QC2018102"]}]},{"name":"President Foundation of The First Affiliated Hospital of Harbin Medical University","award":["2019B24"],"award-info":[{"award-number":["2019B24"]}]},{"name":"Applied Technology Research and Development Project of Heilongjiang Provence","award":["GA20C019"],"award-info":[{"award-number":["GA20C019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fat grafting is a popular operative approach for rejuvenation. Some patients requiring facial fat grafting also have acne. Fat grafting may improve acne in some patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to assess whether fat grafting can improve acne and to analyze the mechanism of action by which such improvement occurs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Preoperative and postoperative digital photographs were examined retrospectively in 229 patients who underwent fat grafting to compare the numbers of inflammatory acne lesions. In addition, 18 patients with acne who were treated by injection of subdermal stromal vascular fraction gel (SVF-gel) were examined prospectively. The numbers of inflammatory acne lesions before and after treatment were measured, and changes in the levels of CD4+ T-cell infiltration were determined from immunohistochemical staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 229 retrospectively evaluated patients who underwent fat grafting, 22 had acne and had complete follow-up data; in these patients, the numbers of acne lesions were significantly lower after than before treatment. The 18 patients who received subdermal SVF-gel injection showed evident improvements in inflammatory lesions after more than 1 year of follow-up. CD4+ T-cell infiltration was significantly decreased at week 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Facial fat grafting can improve inflammatory acne lesions, perhaps because adipose-derived stem cells, which are plentiful in SVF-gel, reduce CD4+ T-cell-mediated inflammation responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence: 4<\/jats:title>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/asj\/sjab162","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T09:07:07Z","timestamp":1617700027000},"page":"NP1061-NP1072","source":"Crossref","is-referenced-by-count":14,"title":["An Efficacy Study of a New Radical Treatment for Acne Vulgaris Using Fat Injection"],"prefix":"10.1093","volume":"41","author":[{"given":"Hongli","family":"Zhao","sequence":"first","affiliation":[{"name":"Center of Plastic and Aesthetic Surgery, The First Affiliated Hospital of Harbin Medical University , Nangang, Harbin , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-693X","authenticated-orcid":false,"given":"Lijun","family":"Hao","sequence":"additional","affiliation":[{"name":"Center of Plastic and Aesthetic Surgery, The First Affiliated Hospital of Harbin Medical University , Nangang, Harbin , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Chen","sequence":"additional","affiliation":[{"name":"Center of Plastic and Aesthetic Surgery, The First Affiliated Hospital of Harbin Medical University , Nangang, Harbin , People\u2019s Republic of 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