{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:03:37Z","timestamp":1793325817029,"version":"4.5.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The shape of the mandible is the fundamental determinant of the appearance and sexual dimorphism of the lower one-third of the face. Utilization of computer-aided design\/computer-aided manufactured (CAD\/CAM) alloplastic implants provides unparalleled planning and sophistication in the correction of skeletal deficiencies, irregularities, and asymmetry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study presented the rationale, indications, techniques, and results of the senior author\u2019s (M.J.Y.) 15-year experience employing CAD\/CAM alloplastic implants to correct deficiencies and asymmetries of the mandible.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective review of a prospectively maintained database was reviewed of all patients who underwent aesthetic augmentation of the mandible employing CAD\/CAM alloplastic implants by the senior author.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Over a 15-year period, 123 patients underwent mandibular augmentation utilizing CAD\/CAM alloplastic implants. The majority of patients were men (76.4%) with an average age of 31 years (range, 24-63 years). All implants were bilateral. Complications included infection requiring implant removal (2.4%) and patient dissatisfaction resulting in either implant revision (4.1%) or implant removal (2.4%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>As described here, CAD\/CAM alloplastic implants are an effective modality to augment aesthetic mandible contour deficiencies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Level of Evidence: 4<\/jats:title>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/asj\/sjab200","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T21:34:12Z","timestamp":1619127252000},"page":"NP1265-NP1275","source":"Crossref","is-referenced-by-count":6,"title":["Changing Mandible Contour Using Computer Designed\/Computer Manufactured Alloplastic Implants"],"prefix":"10.1093","volume":"41","author":[{"given":"David M","family":"Straughan","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Massachusetts General Hospital and Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Yaremchuk","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Massachusetts General Hospital and Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"issue":"5","key":"2022121908175657800_CIT0001","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1055\/s-0038-1669401","article-title":"Ideal facial relationships and goals","volume":"34","author":"Bueller","year":"2018","journal-title":"Facial Plast Surg"},{"issue":"5","key":"2022121908175657800_CIT0002","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/joa.12949","article-title":"Quantification of mandibular sexual dimorphism during adolescence","volume":"234","author":"Fan","year":"2019","journal-title":"J Anat"},{"issue":"6","key":"2022121908175657800_CIT0003","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.asj.2009.08.021","article-title":"Aesthetic surgery of the face and neck","volume":"29","author":"Barton","year":"2009","journal-title":"Aesthet Surg J"},{"issue":"4","key":"2022121908175657800_CIT0004","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/00006534-199404000-00009","article-title":"The roles of revascularization and resorption on endurance of craniofacial onlay bone grafts in the rabbit","volume":"93","author":"Chen","year":"1994","journal-title":"Plast Reconstr Surg"},{"issue":"5","key":"2022121908175657800_CIT0005","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00266-010-9519-5","article-title":"Mechanotransduction: the missing link in the facial aging puzzle?","volume":"34","author":"Sharabi","year":"2010","journal-title":"Aesthetic Plast Surg"},{"issue":"5","key":"2022121908175657800_CIT0006","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1097\/PRS.0b013e31820e9263","article-title":"Alloplastic augmentation of the facial skeleton: an occasional adjunct or alternative to orthognathic surgery","volume":"127","author":"Yaremchuk","year":"2011","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"2022121908175657800_CIT0007","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/PRS.0000000000004652","article-title":"Refining post-orthognathic surgery facial contour with computer-designed\/computer-manufactured alloplastic implants","volume":"142","author":"Lee","year":"2018","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"2022121908175657800_CIT0008","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/00006534-200009010-00030","article-title":"Mandibular augmentation","volume":"106","author":"Yaremchuk","year":"2000","journal-title":"Plast Reconstr Surg"},{"issue":"6","key":"2022121908175657800_CIT0009","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.asj.2009.09.006","article-title":"Masseter muscle reattachment after mandibular angle surgery","volume":"29","author":"Thomas","year":"2009","journal-title":"Aesthet Surg J"}],"container-title":["Aesthetic Surgery 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