{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:46:28Z","timestamp":1783734388137,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015516","name":"Revance Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015516","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Evidence Scientific Solutions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Precise injection technique is vital for avoiding suboptimal eyebrow position when treating glabellar lines with botulinum toxin type A.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this study was to evaluate the impact of glabellar injection technique on eyebrow position in patients treated with DaxibotulinumtoxinA for Injection (DAXI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective post hoc analysis involved 60 adults who received a single treatment with DAXI 40 U to the glabella and had standardized facial photography. Median vertical and horizontal displacement of the brows (at rest) at baseline and 2 weeks after glabellar injection were measured. Brow position outcomes were evaluated by an oculoplastic surgeon and expert anatomist. Investigators were interviewed to ascertain individual injection techniques.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Precise injection location and depth, and median resting brow position following treatment varied between investigators. Positive brow outcomes were achieved with deep DAXI injections into the medial corrugator, superficial lateral corrugator injections placed between the midpupil and lateral limbus, and deep midline procerus injections. Glabellar injection technique that more precisely targeted the corrugator muscles resulted in longer glabellar line treatment duration compared to a less targeted technique. Medial corrugator injections above the medial brow; lateral corrugator injections administered deeply or more medially, toward the medial third of the brow; and procerus injections superior to the inferomedial brow tended to be associated with suboptimal outcomes that were more apparent during dynamic expression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Aesthetically pleasing brow outcomes and greater duration of efficacy can be achieved with an injection pattern that precisely treats the anatomic location of the corrugator supercilii and procerus muscles, avoiding the frontalis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Level of Evidence: 4<\/jats:title>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/asj\/sjac002","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:53:14Z","timestamp":1667407994000},"page":"S10-S18","source":"Crossref","is-referenced-by-count":10,"title":["Impact of Glabellar Injection Technique With DaxibotulinumtoxinA for Injection on Brow Position"],"prefix":"10.1093","volume":"43","author":[{"given":"Vince","family":"Bertucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy B","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Fezza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor J","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nowell","family":"Solish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"2023111118055955200_CIT0001","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2147\/CCID.S138274","article-title":"Tailored botulinum toxin type A injections in aesthetic medicine: consensus panel recommendations for treating the forehead based on individual facial anatomy and muscle tone","volume":"10","author":"Anido","year":"2017","journal-title":"Clin Cosmet Investig Dermatol."},{"issue":"4","key":"2023111118055955200_CIT0002","first-page":"s5","article-title":"Re-examining the optimal use of neuromodulators and the changing landscape: a consensus panel update","volume":"19","author":"Kaminer","year":"2020","journal-title":"J Drugs Dermatol."},{"issue":"3","key":"2023111118055955200_CIT0003","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1097\/00006534-200003000-00046","article-title":"Temporal brow lift using botulinum toxin A","volume":"105","author":"Ahn","year":"2000","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"2023111118055955200_CIT0004","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/archotol.124.3.321","article-title":"Chemical browlift","volume":"124","author":"Frankel","year":"1998","journal-title":"Arch Otolaryngol Head Neck Surg."},{"issue":"1","key":"2023111118055955200_CIT0005","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1524-4725.2000.99147.x","article-title":"Browlift with botulinum toxin","volume":"26","author":"Huang","year":"2000","journal-title":"Dermatol Surg."},{"issue":"9","key":"2023111118055955200_CIT0006","first-page":"1151","article-title":"Tox outside the box: off-label aesthetic uses of botulinum toxin","volume":"15","author":"Lupo","year":"2016","journal-title":"J Drugs Dermatol"},{"issue":"1","key":"2023111118055955200_CIT0007","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1055\/s-2007-967748","article-title":"Balanced botox chemodenervation of the upper face: symmetry in motion","volume":"21","author":"Olson","year":"2007","journal-title":"Semin Plast Surg."},{"issue":"6","key":"2023111118055955200_CIT0008","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ad.2015.04.003","article-title":"Ten mistakes to avoid when injecting botulinum toxin","volume":"106","author":"Ruiz-Rodriguez","year":"2015","journal-title":"Actas Dermosifiliogr."},{"key":"2023111118055955200_CIT0009","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3109\/9781841847559.002","volume-title":"Botulinum Toxins in Clinical Aesthetic Practice","author":"Spencer","year":"2011"},{"issue":"5","key":"2023111118055955200_CIT0010","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00266-013-0178-1","article-title":"Understanding the functional anatomy of the frontalis and glabellar complex for optimal aesthetic botulinum toxin type A therapy","volume":"37","author":"Lorenc","year":"2013","journal-title":"Aesthetic Plast Surg."},{"issue":"1","key":"2023111118055955200_CIT0011","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/PRS.0000000000003919","article-title":"The impact of botulinum toxin on brow height and morphology: a randomized controlled trial","volume":"141","author":"El-Khoury","year":"2018","journal-title":"Plast Reconstr Surg."},{"issue":"1","key":"2023111118055955200_CIT0012","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1111\/j.1524-4725.2006.32328.x","article-title":"Eyebrow height after botulinum toxin type A to the glabella","volume":"33","author":"Carruthers","year":"2007","journal-title":"Dermatol Surg."},{"issue":"4","key":"2023111118055955200_CIT0013","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/PRS.0000000000008966","article-title":"The anatomy behind eyebrow positioning\u2014a clinical guide based on current anatomic concepts","volume":"149","author":"Cotofana","year":"2022","journal-title":"Plast Reconstr Surg."},{"issue":"2","key":"2023111118055955200_CIT0014","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00405-014-3356-0","article-title":"Aesthetic analysis of the ideal eyebrow shape and position","volume":"273","author":"Yal\u00e7\u0131nkaya","year":"2016","journal-title":"Eur Arch Otorhinolaryngol."},{"issue":"3","key":"2023111118055955200_CIT0015","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/jocd.13266","article-title":"Complications of botulinum toxin and fillers: a narrative review","volume":"19","author":"Kassir","year":"2020","journal-title":"J Cosmet Dermatol."},{"issue":"11","key":"2023111118055955200_CIT0016","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/j.1468-3083.2010.03631.x","article-title":"International consensus recommendations on the aesthetic usage of botulinum toxin type A (Speywood Unit)\u2014part I: upper facial wrinkles","volume":"24","author":"Ascher","year":"2010","journal-title":"J Eur Acad Dermatol Venereol."},{"issue":"3","key":"2023111118055955200_CIT0017","doi-asserted-by":"crossref","first-page":"518e","DOI":"10.1097\/01.prs.0000475758.63709.23","article-title":"Global aesthetics consensus: botulinum toxin type A\u2014evidence-based review, emerging concepts, and consensus recommendations for aesthetic use, including updates on complications","volume":"137","author":"Sundaram","year":"2016","journal-title":"Plast Reconstr Surg."},{"issue":"4","key":"2023111118055955200_CIT0018","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.jaad.2019.06.1313","article-title":"DaxibotulinumtoxinA for Injection has a prolonged duration of response in the treatment of glabellar lines: pooled data from two multicenter, randomized, double-blind, placebo-controlled, phase 3 studies (SAKURA 1 and SAKURA 2)","volume":"82","author":"Bertucci","year":"2020","journal-title":"J Am Acad Dermatol."},{"issue":"1","key":"2023111118055955200_CIT0019","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/PRS.0000000000006327","article-title":"DaxibotulinumtoxinA for Injection for the treatment of glabellar lines: results from each of two multicenter, randomized, double-blind, placebo-controlled, phase 3 studies (SAKURA 1 and SAKURA 2)","volume":"145","author":"Carruthers","year":"2020","journal-title":"Plast Reconstr Surg."},{"issue":"1","key":"2023111118055955200_CIT0020","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/DSS.0000000000002531","article-title":"DaxibotulinumtoxinA for Injection for the treatment of glabellar lines: efficacy results from SAKURA 3, a large, open-label, phase 3 safety study","volume":"47","author":"Fabi","year":"2021","journal-title":"Dermatol Surg."},{"issue":"1","key":"2023111118055955200_CIT0021","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/DSS.0000000000002463","article-title":"A large, open-label, phase 3 safety study of DaxibotulinumtoxinA for Injection in glabellar lines: a focus on safety from the SAKURA 3 study","volume":"47","author":"Green","year":"2021","journal-title":"Dermatol Surg."},{"key":"2023111118055955200_CIT0022","author":"Efficacy and safety of daxibotulinumtoxinA (DAXI) for injection for treatment of forehead lines (Frontalis)."},{"key":"2023111118055955200_CIT0023","article-title":"A phase 2a dose-escalation study to evaluate the efficacy and safety of DaxibotulinumtoxinA for Injection for the treatment of dynamic forehead lines following glabellar line injections: an interim analysis","author":"Solish","year":"2020"},{"issue":"S1","key":"2023111118055955200_CIT0024","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1093\/asj\/sjab362","article-title":"Impact of DaxibotulinumtoxinA for Injection on brow position and frontalis muscle activity following treatment of glabellar lines","volume":"43","author":"Solish","year":"2023","journal-title":"Aesthet Surg J."},{"issue":"8","key":"2023111118055955200_CIT0025","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/00042728-200508000-00006","article-title":"Measurement of the anatomic position of the corrugator supercilii","volume":"31","author":"Benedetto","year":"2005","journal-title":"Dermatol Surg."},{"issue":"12","key":"2023111118055955200_CIT0026","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1001\/archotol.124.12.1315","article-title":"An anatomical approach to glabellar rhytids","volume":"124","author":"Macdonald","year":"1998","journal-title":"Arch Otolaryngol Head Neck Surg."},{"issue":"5","key":"2023111118055955200_CIT0027","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/ca.23507","article-title":"Three-dimensional territory and depth of the corrugator supercilii: application to botulinum neurotoxin injection","volume":"33","author":"Lee","year":"2020","journal-title":"Clin Anat."},{"issue":"6","key":"2023111118055955200_CIT0028","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1111\/jocd.14133","article-title":"Respecting upper facial anatomy for treating the glabella with neuromodulators to avoid medial brow ptosis\u2014a refined 3-point injection technique","volume":"20","author":"Cotofana","year":"2021","journal-title":"J Cosmet Dermatol."},{"issue":"5","key":"2023111118055955200_CIT0029","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1007\/s00266-020-01691-5","article-title":"Advanced techniques for the use of neurotoxins in non-surgical facial rejuvenation","volume":"44","author":"Cohn","year":"2020","journal-title":"Aesthetic Plast Surg."},{"issue":"5","key":"2023111118055955200_CIT0030","doi-asserted-by":"crossref","first-page":"e0177239","DOI":"10.1371\/journal.pone.0177239","article-title":"Mapping the emotional face. How individual face parts contribute to successful emotion recognition","volume":"12","author":"Wegrzyn","year":"2017","journal-title":"PLoS One."}],"container-title":["Aesthetic Surgery Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/43\/Supplement_1\/S10\/53242377\/sjac002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/advance-article-pdf\/doi\/10.1093\/asj\/sjac002\/48449220\/sjac002.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/43\/Supplement_1\/S10\/53242377\/sjac002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T18:09:03Z","timestamp":1699726143000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/asj\/article\/43\/Supplement_1\/S10\/6793998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":30,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2022,11,2]]},"published-print":{"date-parts":[[2023,11,9]]}},"URL":"https:\/\/doi.org\/10.1093\/asj\/sjac002","relation":{},"ISSN":["1090-820X","1527-330X"],"issn-type":[{"value":"1090-820X","type":"print"},{"value":"1527-330X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12]]},"published":{"date-parts":[[2022,11,2]]}}}