{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:46:06Z","timestamp":1775094366090,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82102356"],"award-info":[{"award-number":["82102356"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"crossref","award":["2021J05"],"award-info":[{"award-number":["2021J05"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"crossref","award":["YJSCX202088HYD"],"award-info":[{"award-number":["YJSCX202088HYD"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Applied Technology Research and Development Project of Heilongjiang Province","award":["GA20C019"],"award-info":[{"award-number":["GA20C019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>As a derivative of adipose tissues, stromal vascular fraction gel has been widely utilized in facial soft tissue filling, but it still does not achieve the expected effect in forehead filling. The reason may be related to the corrugator muscles movements.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The authors aimed to evaluate the effect of botulinum toxin-A (BTX-A) on the retention rate of stromal vascular fraction gel by limiting the corrugator muscles movements and to provide a theoretical basis that short-term inhibition of movement in the affected area could improve the effects of the fat graft.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From January 2019 to June 2021, patients with stromal vascular fraction gel facial filling (including frontal and temporal parts) were selected. According to whether or not BTX-A treatment was received, patients were divided into injected and the noninjected groups. A questionnaire and the Global Aesthetic Improvement Scale (GAIS) were administered to evaluate 2-dimensional photos. The retention rate and curvature were calculated with 3-dimensional images utilizing Artec Studio 13 Professional and MATLAB software.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The graft retention, forehead curvature, and GAIS scores were all higher in the injected group than the noninjected group (P &amp;lt; .01). On the questionnaire, the injected group also showed more satisfaction with the treatment effect and were more willing to recommend the treatment to their friends.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>BTX-A injection can improve the retention rate of prefrontal stromal vascular fraction gel filling, with higher patient satisfaction and better postoperative effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Level of Evidence: 5<\/jats:title>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/asj\/sjac332","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T12:33:42Z","timestamp":1670675622000},"page":"NP202-NP212","source":"Crossref","is-referenced-by-count":2,"title":["The Retention-Rate Improvement of Stromal Vascular Fraction Gel in Prefrontal Filling With Botulinum Toxin-A Injection: A Retrospective Analysis"],"prefix":"10.1093","volume":"43","author":[{"given":"Zhizhou","family":"Wang","sequence":"first","affiliation":[{"name":"From the Plastic and Aesthetic Center, The First Affiliated Hospital of Harbin Medical University , Harbin, Heilongjiang Province , People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Cheng","sequence":"additional","affiliation":[{"name":"From the Plastic and Aesthetic Center, The First Affiliated Hospital of Harbin Medical University , Harbin, Heilongjiang Province , People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyang","family":"Du","sequence":"additional","affiliation":[{"name":"From the Plastic and Aesthetic Center, The First Affiliated Hospital of Harbin Medical University , Harbin, Heilongjiang Province , People's Republic of 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