{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:27:21Z","timestamp":1775662041539,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100003559","name":"The Aesthetic Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003559","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Deoxycholic acid (ATX-101) is a drug administered by subcutaneous injection for local fat reduction. However, ATX-101 treatment has been reported to cause marginal mandibular nerve injury with noticeable functional deficits when targeting submental fat. As a cytolytic agent with some selectivity for adipocytes, ATX-101 may damage the lipid-rich myelin surrounding peripheral nerves.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this study was to characterize nerve injury caused by ATX-101 injection in an experimental rat sciatic nerve model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Injuries to the sciatic nerve caused by intrafascicular and extrafascicular injections of ATX-101, and by lidocaine (positive control) and saline (negative control) injections, were compared. Nerves were harvested at a 2-week endpoint for histomorphometric analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The cross-sectional area of nerve injury was significantly increased by ATX-101 injection. The damaged areas amounted to 75% \u00b1 15% with intrafascicular ATX-101 (P &amp;lt; .001), 41% \u00b1 21% with extrafascicular ATX-101 (P &amp;lt; .01), and 38% \u00b1 20% with positive-control lidocaine (P &amp;lt; .01), compared with 7% \u00b1 13% with negative-control saline. Demyelinating injury was a significant mechanism of injury in the affected nerve fibers compared with uninjured nerve fibers (P &amp;lt; .04), but there was no difference in the axon-to-myelin area ratio between the lidocaine and ATX-101 cohorts. After 2 weeks, Wallerian degeneration was evident with only small regenerating nerve fibers present in the ATX-101-injured groups compared with saline (average fiber width, 2.54 \u00b1 0.26\u2005\u03bcm vs 5.03 \u00b1 0.44\u2005\u03bcm, P &amp;lt; .001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ATX-101 can cause extensive nerve injury in rats. The mechanism of action for ATX-101 does not preferentially target myelin more than other common neurotoxic agents. Appropriate knowledge of surgical anatomy and injection technique is necessary for any practitioners administering ATX-101 injections.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/asj\/sjae198","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T14:25:44Z","timestamp":1727187944000},"page":"186-193","source":"Crossref","is-referenced-by-count":2,"title":["Peripheral Nerve Injury After Deoxycholic Acid (ATX-101) Injection in an Experimental Rat 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