{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:31:12Z","timestamp":1787067072532,"version":"build-2736575974"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Platelet-rich plasma (PRP)-derived exosomes have been used for a very long time in genital area rejuvenation applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The authors of this study aim to investigate the effect of the newly defined genital PRP-derived exosome injection point compared with conventional genital injection points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PRP-derived exosomes were taken into two 1\u2005cc syringes. Four injection areas were determined. Only 1 area was injected in each group. In Group A, a total of 2\u2005cc of exosome was injected into the right and left lateral parts of the clitoral glans at 3 to 9 o'clock with a 32\u2005G 4\u2005mm syringe tip. The procedure was applied so that the entire 4\u2005mm syringe tip entered the tissue. In Group B, a total of 2\u2005cc of exosome was injected into the G-spot area around the distal third of the anterior wall with a point-by-point technique with a 32\u2005G 4\u2005mm syringe tip. In Group C, exosome injection was performed with a 32\u2005G 4\u2005mm syringe tip, 1\u2005cc on the right side, 1\u2005cc on the left side, and 2\u2005cc in total, to the periurethral area. In Group D, exosome injection was performed at the junction point of frenulum, prepuce, and labium minus and its surroundings: 1\u2005cc on the right side, 1\u2005cc on the left side, and 2\u2005cc in total. This procedure was performed in 3 sessions, 4 weeks apart. All patients were evaluated with the Female Sexual Function Index (FSFI) scale before the first session and 6 and 12 months after the third session.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The difference between the FSFI increase levels in 2 different periods for each group was evaluated. Accordingly, the FSFI increase in Group A was similar to the increase in Group D (P = .715). The FSFI increase in Group B was similar to the increase in Group C (P = .437). The FSFI increase in Groups A and D was statistically greater than the increase in Groups B and C (Group A vs Group B, P = .001; Group A vs Group C, P = .015; Group D vs Group B, P = .027; Group D vs Group C, P = .018).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study is the first example in the literature in terms of evaluating the difference between the points where PRP-derived exosomes were applied. This new point injection increased FSFI better than Group A and was as effective as Groups B and C. The effectiveness of this newly defined method has been investigated with a single-point injection point, and it is seen that the frequency of application will increase because of its easy applicability, low cost and low side effect rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence: 4 (Therapeutic)<\/jats:title>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/asj\/sjaf104","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T07:31:14Z","timestamp":1748935874000},"page":"922-927","source":"Crossref","is-referenced-by-count":2,"title":["Platelet-Derived Exosome Vulvar Injections for Sexual Dysfunction: A Retrospective Review"],"prefix":"10.1093","volume":"45","author":[{"given":"Savas 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