{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:22:13Z","timestamp":1773073333209,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Kimera Labs"},{"name":"ExoCoBio"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Exosome therapy represents an emerging regenerative medicine approach for optimizing wound healing and reducing scarring. Extensive pre-clinical research on human placental mesenchymal stem cell-derived exosomes (hpMSC-exosomes) demonstrates significant therapeutic potential in aesthetic and reconstructive surgery applications. Despite compelling preclinical evidence supporting the efficacy of exosomes in wound healing, human clinical studies remain scarce. The author's current study includes 738 patients treated with hpMSC-exosomes over a 7-year period across multiple aesthetic and reconstructive indications, with 175 cases involving wound healing and 118 cases involving scar therapy. The objective of this systematic review and meta-analysis is to comprehensively evaluate the current evidence for hpMSC-exosomes in wound healing and scar therapy, analyzing their mechanisms of action, clinical applications, and safety profiles through a review of preclinical studies, safety data, and clinical case series in both animals and humans. Analysis of the author's series will be included. Information sources included PubMed, Cochrane Library, EMBASE, Web of Science, and ClinicalTrials.gov resulting in a meta-analysis of 21 global preclinical studies (323 animals) which demonstrated superior outcomes compared with controls across multiple parameters: wound healing rate, neovascular density, re-epithelialization rate, and collagen deposition. hpMSC-exosomes demonstrated accelerated wound healing through enhanced angiogenesis, reduced inflammation, improved collagen production, and immunomodulatory effects. Most studies utilized rodent models, with limited translation to human trials. Current human evidence is predominantly based on early-phase trials, case series, and observational studies. Large-scale, well-designed clinical trials are essential to advancing exosome therapy in wound healing and scar management. hp-MSC-exosomes represent a promising therapeutic modality for wound healing and scar therapy with demonstrated safety and efficacy. Standardization of manufacturing processes and FDA approval remain critical for widespread clinical implementation.<\/jats:p>\n                  <jats:p>Level of Evidence: 3 (Therapeutic) \u00a0<\/jats:p>","DOI":"10.1093\/asj\/sjaf163","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T12:04:21Z","timestamp":1754654661000},"page":"S54-S61","source":"Crossref","is-referenced-by-count":0,"title":["Human Placental Mesenchymal Stem Cell-Derived Exosomes in Wound Healing and Scar Therapy: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"46","author":[{"given":"Greg","family":"Chernoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"2026030906364288700_sjaf163-B1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/0022034509359125","article-title":"Factors affecting wound healing","volume":"89","author":"Guo","year":"2010","journal-title":"J Dent Res"},{"key":"2026030906364288700_sjaf163-B2","doi-asserted-by":"publisher","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles","volume":"7","author":"Thery","year":"2018","journal-title":"J Extracell Vesicles"},{"key":"2026030906364288700_sjaf163-B3","doi-asserted-by":"publisher","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"2026030906364288700_sjaf163-B4","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1524-475X.2011.00673.x","article-title":"Dynamic reciprocity in the wound microenvironment","volume":"19","author":"Schultz","year":"2011","journal-title":"Wound Repair Regen"},{"key":"2026030906364288700_sjaf163-B5","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.ydbio.2017.08.007","article-title":"The blastema and epimorphic regeneration in mammals","volume":"433","author":"Seifert","year":"2018","journal-title":"Dev Biol"},{"key":"2026030906364288700_sjaf163-B6","doi-asserted-by":"publisher","first-page":"142","DOI":"10.5966\/sctm.2011-0018","article-title":"Concise review: role of mesenchymal stem cells in wound repair","volume":"1","author":"Maxson","year":"2012","journal-title":"Stem Cells Transl Med"},{"key":"2026030906364288700_sjaf163-B7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s41038-017-0103-y","article-title":"Tissue engineering of skin and regenerative medicine for wound care","volume":"6","author":"Boyce","year":"2018","journal-title":"Burns Trauma"},{"key":"2026030906364288700_sjaf163-B8","author":"FDA Center for Biologics Evaluation and Research"},{"key":"2026030906364288700_sjaf163-B9","doi-asserted-by":"publisher","first-page":"121391","DOI":"10.1016\/j.lfs.2023.121391","article-title":"The effectiveness of cell-derived exosome therapy for diabetic wound: a systematic review and meta-analysis","volume":"316","author":"Li","year":"2023","journal-title":"Life Sci"},{"key":"2026030906364288700_sjaf163-B10","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.jid.2021.07.167","article-title":"Role of exosomes in dermal wound healing: a systematic review","volume":"142","author":"Prasai","year":"2022","journal-title":"J Invest Dermatol"},{"key":"2026030906364288700_sjaf163-B11","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1007\/s12015-021-10164-4","article-title":"MSC-derived extracellular vesicles to heal diabetic wounds: a systematic review and meta-analysis of preclinical animal studies","volume":"18","author":"Bailey","year":"2022","journal-title":"Stem Cell Rev Rep"},{"key":"2026030906364288700_sjaf163-B12","doi-asserted-by":"publisher","first-page":"tkae025","DOI":"10.1093\/burnst\/tkae025","article-title":"Adipose stem cell-derived exosomes in the treatment of wound healing in preclinical animal models: a meta-analysis","volume":"12","author":"Wei","year":"2024","journal-title":"Burns Trauma"},{"key":"2026030906364288700_sjaf163-B13","doi-asserted-by":"publisher","first-page":"6455","DOI":"10.7150\/thno.73436","article-title":"Efficacy and safety of small extracellular vesicle interventions in wound healing and skin regeneration: a systematic review and meta-analysis of animal studies","volume":"12","author":"Al-Masawa","year":"2022","journal-title":"Theranostics"},{"key":"2026030906364288700_sjaf163-B14","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.3390\/biomedicines11082099","article-title":"Advancements and insights in exosome-based therapies for wound healing: a comprehensive systematic review (2018-June 2023)","volume":"11","author":"Sousa","year":"2023","journal-title":"Biomedicines"},{"key":"2026030906364288700_sjaf163-B15","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00266-024-04276-8","article-title":"Exosomes exposed: overview systematic review on evidence versus expectation in aesthetic and regenerative medicine","volume":"49","author":"Rahman","year":"2025","journal-title":"Aesthetic Plast Surg"},{"key":"2026030906364288700_sjaf163-B16","doi-asserted-by":"publisher","first-page":"NP1150","DOI":"10.1093\/asj\/sjab123","article-title":"Clinical outcomes with human placental mesenchymal stem cell derived exosomes in keloid scar therapy","volume":"41","author":"Chernoff","year":"2021","journal-title":"Aesthet Surg J"},{"key":"2026030906364288700_sjaf163-B17","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13287-019-1253-6","article-title":"Human embryonic stem cell-derived exosomes promote pressure ulcer healing in aged mice by rejuvenating senescent endothelial cells","volume":"10","author":"Chen","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"2026030906364288700_sjaf163-B18","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.5966\/sctm.2015-0367","article-title":"Umbilical cord-derived mesenchymal stem cell-derived exosomal microRNAs suppress myofibroblast differentiation by inhibiting the transforming growth factor\u00ad\u03b2\/SMAD2 pathway during wound healing","volume":"5","author":"Fang","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"2026030906364288700_sjaf163-B19","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ebiom.2018.10.044","article-title":"Exosome derived from human umbilical cord mesenchymal stem cell mediates MiR-181c attenuating burn-induced excessive inflammation","volume":"37","author":"Li","year":"2018","journal-title":"EBioMedicine"},{"key":"2026030906364288700_sjaf163-B20","doi-asserted-by":"publisher","first-page":"e3098","DOI":"10.1097\/GOX.0000000000003098","article-title":"Safety profile of human placental mesenchymal stem cell derived exosomes: comprehensive analysis of 700 patients","volume":"8","author":"Chernoff","year":"2020","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"2026030906364288700_sjaf163-B21","doi-asserted-by":"publisher","first-page":"4651","DOI":"10.1182\/blood.V87.11.4651.bloodjournal87114651","article-title":"Platelet-derived microparticles associate with fibrin during thrombosis","volume":"87","author":"Siijander","year":"1996","journal-title":"Blood"},{"key":"2026030906364288700_sjaf163-B22","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1182\/blood-2008-07-167148","article-title":"Lactadherin and clearance of platelet-derived microvesicles","volume":"113","author":"Dasgupta","year":"2009","journal-title":"Blood"},{"key":"2026030906364288700_sjaf163-B23","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1161\/01.cir.101.8.841","article-title":"Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes","volume":"101","author":"Mallat","year":"2000","journal-title":"Circulation"},{"key":"2026030906364288700_sjaf163-B24","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s10735-017-9711-x","article-title":"Exosomes derived from human amniotic epithelial cells accelerate wound healing and inhibit scar formation","volume":"48","author":"Zhao","year":"2017","journal-title":"J Mol Histol"},{"key":"2026030906364288700_sjaf163-B25","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1186\/s12967-015-0642-6","article-title":"LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b","volume":"13","author":"Ti","year":"2015","journal-title":"J Transl Med"},{"key":"2026030906364288700_sjaf163-B26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12967-015-0417-0","article-title":"Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis","volume":"13","author":"Zhang","year":"2015","journal-title":"J Transl Med"},{"key":"2026030906364288700_sjaf163-B27","doi-asserted-by":"publisher","first-page":"32993","DOI":"10.1038\/srep32993","article-title":"Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts","volume":"6","author":"Hu","year":"2016","journal-title":"Sci Rep"},{"key":"2026030906364288700_sjaf163-B28","doi-asserted-by":"publisher","first-page":"10279","DOI":"10.1021\/acsnano.9b03656","article-title":"Efficient angiogenesis-based diabetic wound healing\/skin reconstruction through bioactive antibacterial adhesive ultraviolet shielding nanodressing with exosome release","volume":"13","author":"Wang","year":"2019","journal-title":"ACS Nano"},{"key":"2026030906364288700_sjaf163-B29","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1089\/scd.2014.0316","article-title":"Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro","volume":"24","author":"Shabbir","year":"2015","journal-title":"Stem Cells Dev"},{"key":"2026030906364288700_sjaf163-B30","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1002\/stem.1771","article-title":"HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing","volume":"33","author":"Zhang","year":"2015","journal-title":"Stem Cells"},{"key":"2026030906364288700_sjaf163-B31","doi-asserted-by":"publisher","first-page":"30081","DOI":"10.1021\/acsami.8b08449","article-title":"Enhanced therapeutic effects of mesenchymal stem cell-derived exosomes with an injectable hydrogel for hindlimb ischemia treatment","volume":"10","author":"Zhang","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"2026030906364288700_sjaf163-B32","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1089\/wound.2017.0775","article-title":"Human adipose-derived stem cell conditioned media and exosomes containing MALAT1 promote human dermal fibroblast migration and ischemic wound healing","volume":"7","author":"Cooper","year":"2018","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"2026030906364288700_sjaf163-B33","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3389\/fmolb.2020.00119","article-title":"Differential wound healing capacity of mesenchymal stem cell-derived exosomes originated from bone marrow, adipose tissue and umbilical cord under serum\u00ad and xeno-free condition","volume":"7","author":"Hoang","year":"2020","journal-title":"Front Mol Biosci"},{"key":"2026030906364288700_sjaf163-B34","doi-asserted-by":"publisher","first-page":"115S","DOI":"10.1016\/j.jvs.2018.01.065","article-title":"Acceleration of diabetic wound healing with adipose-derived stem cells, endothelial-differentiated stem cells, and topical conditioned medium therapy in a swine model","volume":"68","author":"Irons","year":"2018","journal-title":"J Vasc Surg"},{"key":"2026030906364288700_sjaf163-B35","doi-asserted-by":"publisher","first-page":"C848","DOI":"10.1152\/ajpcell.00041.2020","article-title":"Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p\/SIRT1- mediated autophagy","volume":"318","author":"Shi","year":"2020","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026030906364288700_sjaf163-B36","doi-asserted-by":"publisher","first-page":"9742765","DOI":"10.1155\/2019\/9742765","article-title":"Exosomes derived from human bone marrow mesenchymal stem cells stimulated by deferoxamine accelerate cutaneous wound healing by promoting angiogenesis","volume":"2019","author":"Ding","year":"2019","journal-title":"Biomed Res Int"},{"key":"2026030906364288700_sjaf163-B37","doi-asserted-by":"publisher","first-page":"811","DOI":"10.3390\/ph14080811","article-title":"Extracellular vesicles in skin wound healing","volume":"14","author":"Narauskaite","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"2026030906364288700_sjaf163-B38","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s13287-020-01723-6","article-title":"Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-\u03b2\/Smad signaling pathway","volume":"11","author":"Jiang","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"2026030906364288700_sjaf163-B39","doi-asserted-by":"publisher","first-page":"2402916","DOI":"10.1155\/2019\/2402916","article-title":"Fetal dermal mesenchymal stem cell-derived exosomes accelerate cutaneous wound healing by activating notch signaling","volume":"2019","author":"Wang","year":"2019","journal-title":"Stem Cells Int"},{"key":"2026030906364288700_sjaf163-B40","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s13287-021-02287-9","article-title":"Combined topical and systemic administration with human adipose\u00adderived mesenchymal stem cells (hADSC) and hADSC-derived exosomes markedly promoted cutaneous wound healing and regeneration","volume":"12","author":"Zhou","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"2026030906364288700_sjaf163-B41","doi-asserted-by":"publisher","first-page":"e12993","DOI":"10.1111\/cpr.12993","article-title":"Exosomes from adipose-derived stem cells and application to skin wound healing","volume":"54","author":"An","year":"2021","journal-title":"Cell Prolif"},{"key":"2026030906364288700_sjaf163-B42","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.freeradbiomed.2007.04.026","article-title":"Methods to detect nitric oxide and its metabolites in biological samples","volume":"43","author":"Bryan","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"2026030906364288700_sjaf163-B43","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nrd2466","article-title":"The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics","volume":"7","author":"Lundberg","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"2026030906364288700_sjaf163-B44","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1161\/01.hyp.38.2.274","article-title":"Age-related reduction of NO availability and oxidative stress in humans","volume":"38","author":"Taddei","year":"2001","journal-title":"Hypertension"},{"key":"2026030906364288700_sjaf163-B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0378-5173(98)00360-3","article-title":"Iontophoresis and electroporation: comparisons and contrasts","volume":"179","author":"Banga","year":"1999","journal-title":"Int J Pharm"},{"key":"2026030906364288700_sjaf163-B46","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.addr.2003.10.02","article-title":"Low-frequency sonophoresis: a review","volume":"56","author":"Mitragotri","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"2026030906364288700_sjaf163-B47","doi-asserted-by":"publisher","first-page":"26316","DOI":"10.3402\/jev.v4.26316","article-title":"Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting","volume":"4","author":"Wiklander","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"2026030906364288700_sjaf163-B48","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.jconrel.2020.06.006","article-title":"Controlled release of odontogenic exosomes from a biodegradable vehicle mediates tooth repair in rats","volume":"324","author":"Swanson","year":"2020","journal-title":"J Control Release"},{"key":"2026030906364288700_sjaf163-B49","doi-asserted-by":"publisher","first-page":"2002070","DOI":"10.1002\/adhm.202002070","article-title":"HOTAIR-loaded mesenchymal stem\/stromal cell extracellular vesicles enhance angiogenesis and wound healing","volume":"11","author":"Born","year":"2022","journal-title":"Adv Healthc Mater"},{"key":"2026030906364288700_sjaf163-B50","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s12967-021-02980-6","article-title":"A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine","volume":"19","author":"Moghadasi","year":"2021","journal-title":"J Transl Med"},{"key":"2026030906364288700_sjaf163-B51","doi-asserted-by":"publisher","first-page":"736","DOI":"10.5966\/sctm.2016-0275","article-title":"Chitosan wound dressings incorporating exosomes derived from microRNA-126-overexpressing synovium mesenchymal stem cells provide sustained release of exosomes and heal full-thickness skin defects in a diabetic rat model","volume":"6","author":"Tao","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"2026030906364288700_sjaf163-B52","doi-asserted-by":"publisher","first-page":"30087","DOI":"10.3402\/jev.v4.30087","article-title":"Applying extracellular vesicles based therapeutics in clinical trials\u2014an ISEV position paper","volume":"4","author":"Lener","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"2026030906364288700_sjaf163-B53","doi-asserted-by":"publisher","first-page":"e346","DOI":"10.1038\/emm.2017.63","article-title":"Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases","volume":"49","author":"Lou","year":"2017","journal-title":"Exp Mol Med"},{"key":"2026030906364288700_sjaf163-B54","doi-asserted-by":"publisher","first-page":"1609206","DOI":"10.1080\/20013078.2019.1609206","article-title":"Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications","volume":"8","author":"Witwer","year":"2019","journal-title":"J Extracell Vesicles"},{"key":"2026030906364288700_sjaf163-B55","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1186\/s13287-021-02378-7","article-title":"Mesenchymal stem\/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities","volume":"12","author":"Hassanzadeh","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"2026030906364288700_sjaf163-B56","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.29011\/2575-9760.001482","article-title":"The utilization of human placental, fetal mesenchymal stem cell derived-exosomes in treating keloid scars","volume":"7","author":"Chernoff","year":"2022","journal-title":"J Surg"},{"key":"2026030906364288700_sjaf163-B57","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1681\/ASN.2008070798","article-title":"Mesenchymal stem cell-derived microvesicles protect against acute tubular injury","volume":"20","author":"Bruno","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"2026030906364288700_sjaf163-B58","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3390\/pharmaceutics10040218","article-title":"Exosomes and exosome-inspired vesicles for targeted drug delivery","volume":"10","author":"Antimisiaris","year":"2018","journal-title":"Pharmaceutics"}],"container-title":["Aesthetic Surgery Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/46\/Supplement_1\/S54\/67279204\/sjaf163.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/46\/Supplement_1\/S54\/67279204\/sjaf163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:36:48Z","timestamp":1773052608000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/asj\/article\/46\/Supplement_1\/S54\/8512050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":58,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2026,3,9]]},"published-print":{"date-parts":[[2026,3,9]]}},"URL":"https:\/\/doi.org\/10.1093\/asj\/sjaf163","relation":{},"ISSN":["1090-820X","1527-330X"],"issn-type":[{"value":"1090-820X","type":"print"},{"value":"1527-330X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,9]]}}}