{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:11:49Z","timestamp":1785809509941,"version":"3.56.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The chin is a crucial facial feature for overall attractiveness. Lower third imbalance can lead to signs of premature aging and loss of jawline contour. Effective chin augmentation with hyaluronic acid fillers has been demonstrated in the literature. Currently, however, no study has compared the safety and effectiveness of two high-G\u2032 fillers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this study was to examine each filler's effectiveness in the correction of chin retrusion through a prospective, randomized, comparator-controlled, evaluator-blinded trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study compared the safety and effectiveness of HASHA (Restylane Shaype) vs HAVLX (Juvederm Volux) for chin augmentation and correction of chin retrusion. A prospective, randomized, comparator-controlled, evaluator-blinded trial was conducted at a single research center. Forty participants aged 18\u2005years or older with mild to severe chin retrusion were included and randomly allocated 1:1 to either HASHA (n = 20) or HAVLX (n = 20). The primary study endpoint was to examine differences in parameters associated with determining chin shape. Secondary endpoints included adverse events and patient satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 40 participants enrolled in the trial, 37 (92.5%) were female and 3 (7.5%) were male. Although an independent-samples t-test revealed no statistically significant difference in total volumes of filler used with HAVLX (mean [standard deviation], 1.85 [0.69] mL) or HASHA (mean, 1.86 [0.89] mL, P = .953). When focused on the menton\/pogonion injections, HAVLX required 15.27% more product than HASHA (mean, 1.48\u2005mL vs 1.27\u2005mL, P = .28). There was a statistically significant difference in efficiency score for correcting labiomental angle, with the mean efficiency score being 2.57 [1.67] for HASHA and 1.50 [1.11] for HAVLX (P = .02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>With no statistically significant difference in overall volume utilized between HASHA and HAVLX, HASHA injections required 15.27% less volume in the menton\/pogonion to achieve visual correction. Additionally, HASHA demonstrated a significantly higher efficiency score for correction of nasomental angle. Secondary endpoints were not significantly different and demonstrate that both products are safe and effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence: 2 (Therapeutic)<\/jats:title>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/asj\/sjaf222","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T12:33:10Z","timestamp":1762777990000},"page":"503-508","source":"Crossref","is-referenced-by-count":1,"title":["Safety and Effectiveness of Two High-\n                    <i>G<\/i>\n                    \u2032 Soft Tissue Fillers for Chin Augmentation: A Prospective, Randomized, Comparator-Controlled, Evaluator-Blinded Trial"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9056-4998","authenticated-orcid":false,"given":"Andreas","family":"Nikolis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Metelitsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Raco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0795-3109","authenticated-orcid":false,"given":"Tyler","family":"Safran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"2026040911524848800_sjaf222-B1","doi-asserted-by":"publisher","first-page":"88","DOI":"10.2319\/050111-311.1","article-title":"Influence of chin height on perceived attractiveness in the orthognathic patient, layperson, and clinician","volume":"82","author":"Naini","year":"2012","journal-title":"Angle Orthod"},{"key":"2026040911524848800_sjaf222-B2","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1007\/s00266-023-03812-2","article-title":"Chin augmentation and treatment of chin retrusion with a flexible hyaluronic acid filler in Asian subjects: a randomized, controlled, evaluator-blinded study","volume":"48","author":"Xie","year":"2024","journal-title":"Aesthetic Plast Surg"},{"key":"2026040911524848800_sjaf222-B3","doi-asserted-by":"publisher","first-page":"1240e","DOI":"10.1097\/PRS.0000000000009733","article-title":"A randomized trial to assess effectiveness and safety of a hyaluronic acid filler for chin augmentation and correction of chin retrusion","volume":"150","author":"Marcus","year":"2022","journal-title":"Plast Reconstr Surg"},{"key":"2026040911524848800_sjaf222-B4","doi-asserted-by":"publisher","first-page":"255","DOI":"10.36849\/JDD.8145","article-title":"Effectiveness and safety of a new hyaluronic acid injectable for augmentation and correction of chin retrusion","volume":"23","author":"Nikolis","year":"2024","journal-title":"J Drugs Dermatol"},{"key":"2026040911524848800_sjaf222-B5","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1097\/DSS.0000000000001960","article-title":"Safe, effective chin and jaw restoration with VYC-25L hyaluronic acid injectable gel","volume":"45","author":"Ogilvie","year":"2019","journal-title":"Dermatol Surg"},{"key":"2026040911524848800_sjaf222-B6","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1097\/DSS.0000000000002269","article-title":"Validation of photonumeric assessment scales for temple volume deficit, infraorbital hollows, and chin retrusion","volume":"46","author":"Moradi","year":"2020","journal-title":"Dermatol Surg"},{"key":"2026040911524848800_sjaf222-B7","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/PRS.0000000000000895","article-title":"FACE-Q scales for health-related quality of life, early life impact, satisfaction with outcomes, and decision to have treatment: development and validation","volume":"135","author":"Klassen","year":"2015","journal-title":"Plast Reconstr Surg"},{"key":"2026040911524848800_sjaf222-B8","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1055\/s-0033-1357113","article-title":"Aesthetic alteration of the chin","volume":"27","author":"Lee","year":"2013","journal-title":"Semin Plast Surg"},{"key":"2026040911524848800_sjaf222-B9","doi-asserted-by":"publisher","first-page":"e5457","DOI":"10.1097\/GOX.0000000000005457","article-title":"Response of 21 hyaluronic acid fillers to recombinant human hyaluronidase","volume":"11","author":"Park","year":"2023","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"2026040911524848800_sjaf222-B10","first-page":"27","article-title":"Brazilian study group for cosmetic procedurestheir complications. Recalcitrant sterile abscesses by volux: a new therapeutic approach","volume":"21","author":"Balassiano","year":"2023","journal-title":"Skinmed"},{"key":"2026040911524848800_sjaf222-B11","doi-asserted-by":"publisher","first-page":"NP499","DOI":"10.1093\/asj\/sjaa013","article-title":"VYC-25L Hyaluronic acid injectable gel is safe and effective for long-term restoration and creation of volume of the lower face","volume":"40","author":"Ogilvie","year":"2020","journal-title":"Aesthet Surg J"},{"key":"2026040911524848800_sjaf222-B12","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1097\/IOP.0000000000002941","article-title":"Identifying minimum single dose of recombinant human hyaluronidase for in vitro dissolution of twenty-two hyaluronic acid fillers","volume":"41","author":"Sudharshan","year":"2025","journal-title":"Ophthalmic Plast Reconstr Surg"},{"issue":"10","key":"2026040911524848800_sjaf222-B13","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1093\/asj\/sjaf127","article-title":"Comparison of the degradability of hyaluronic acid by ovine and recombinant human hyaluronidase","volume":"45","author":"Safran","year":"2025","journal-title":"Aesth Surg Journal"}],"container-title":["Aesthetic Surgery Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/asj\/advance-article-pdf\/doi\/10.1093\/asj\/sjaf222\/65272663\/sjaf222.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/46\/5\/503\/65272663\/sjaf222.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/46\/5\/503\/65272663\/sjaf222.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T15:52:53Z","timestamp":1775749973000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/asj\/article\/46\/5\/503\/8321338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,11,12]]},"published-print":{"date-parts":[[2026,4,7]]}},"URL":"https:\/\/doi.org\/10.1093\/asj\/sjaf222","relation":{},"ISSN":["1090-820X","1527-330X"],"issn-type":[{"value":"1090-820X","type":"print"},{"value":"1527-330X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2025,11,12]]}}}