{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:22:44Z","timestamp":1791901364927,"version":"4.3.4"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite the growing demand for hyaluronic acid (HA) lip fillers, there is a paucity of robust, quantitative data across high-powered studies. This systematic review and meta-analysis aims to assess the efficacy and safety of HA lip fillers as reported by randomized controlled trials (RCTs). A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses 2020 guidelines, utilizing PubMed, Embase, and Cochrane, and eligible studies included RCTs with human participants utilizing HA filler for lip augmentation. Meta-analysis evaluated rates of improvement in lip fullness, aesthetic appearance, patient satisfaction, and adverse events. A comprehensive review initially identified 2038 articles. Following screening by title and abstract, full-text review, and risk of bias assessment with the Cochrane risk-of-bias tool for randomized trials, 16 articles were included in the study. Meta-analysis demonstrated that 60% (95% CI, 44%-76%) had improvement in lip fullness, 82% (95% CI, 67%-92%) had improvement in aesthetic appearance, 68% (95% CI, 58%-78%) reported satisfaction, 50% (95% CI, 27%-73%) had adverse events, and 1.1% (95% CI, 1.9-4.0%) had serious adverse events requiring treatment, needing follow-up, or lasting beyond 30 days. The most common adverse events were swelling (78%), firmness (48%), bruising (34%), and tenderness (33%). Across studies with the highest level of evidence, HA filler efficacy and patient satisfaction was moderate to high. Severe adverse reactions were rare, but adverse events were common.<\/jats:p>\n                  <jats:p>Level of Evidence: 1 (Therapeutic) \u00a0<\/jats:p>","DOI":"10.1093\/asj\/sjaf224","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:09:30Z","timestamp":1761916170000},"page":"NP24-NP32","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of Hyaluronic Acid Lip Fillers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-0014","authenticated-orcid":false,"given":"Y","family":"Edward Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6582-3003","authenticated-orcid":false,"given":"Lucas R","family":"Perez Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey 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