{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:24:12Z","timestamp":1788326652583,"version":"build-2803163510"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serotonergic antidepressants have been associated with an increased risk of weight gain. Because being overweight is strongly linked to macromastia development, which is a primary indication for breast reduction, it is very important to assess whether these medications pose the risk of postoperative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the association between preoperative serotonergic antidepressant use and the incidence of postoperative complications following breast reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort analysis was conducted using the TriNetX Global Collaborative Network. Female patients &amp;gt;18 years old who underwent breast reduction were divided into 2 groups: those with documented serotonergic antidepressant use prior to surgery and those with no history of serotonergic antidepressant use. Propensity score matching was applied to balance demographic and clinical variables. Primary outcomes included postoperative complications at 3 time intervals: 30 days, 60 days, and 90 days. Secondary outcomes included long-term complications after 1 and 2 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 1:1 propensity score matching, each cohort consisted of 8625 patients. Within 30 days following breast reduction, patients in the serotonergic cohort had a significantly increased risk of surgical site infection (risk ratio [RR], 1.42; P = .003), wound dehiscence (RR, 1.524; P &amp;lt; .0001), inpatient hospitalization (RR, 1.375; P = .004), opioid use (1.474, P &amp;lt; .0001), and any surgical site complication (1.28, P &amp;lt; .0001) compared with the control cohort. These elevated risks persisted at 60 and 90 days postsurgery. For long-term outcomes, similar rates were noted after 1 and 2 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serotonergic antidepressant use is associated with an increased risk of short-term postoperative complications following breast reduction surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence: 2 (Therapeutic)<\/jats:title>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/asj\/sjaf271","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T12:48:42Z","timestamp":1766494122000},"page":"336-342","source":"Crossref","is-referenced-by-count":4,"title":["Preoperative Serotonin Antidepressant Use Is Associated With Increased Postoperative Complications Following Breast Reduction: A Propensity-Score-Matched Analysis of a Multi-institutional Database"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8775-0087","authenticated-orcid":false,"given":"Nir","family":"Zontag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-9967","authenticated-orcid":false,"given":"Ron","family":"Skorochod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-510X","authenticated-orcid":false,"given":"Yoram","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"2026030212063060400_sjaf271-B1","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/S10549-023-07216-3","article-title":"Global prevalence and factors associated with preoperative depression in women undergoing breast surgery: a meta-analysis and meta-regression","volume":"205","author":"Leo","year":"2024","journal-title":"Breast Cancer Res Treat"},{"key":"2026030212063060400_sjaf271-B2","doi-asserted-by":"publisher","first-page":"NP684","DOI":"10.1093\/ASJ\/SJAA313","article-title":"Comparison of reconstructive plastic surgery rates and 30-day postoperative complications between patients with and without psychiatric diagnoses","volume":"41","author":"Spataro","year":"2021","journal-title":"Aesthet Surg J"},{"key":"2026030212063060400_sjaf271-B3","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.fsc.2020.06.003","article-title":"Psychiatric disorders in facial plastic surgery","volume":"28","author":"Capi Wever","year":"2020","journal-title":"Facial Plast Surg Clin North Am"},{"key":"2026030212063060400_sjaf271-B4","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/j.bjps.2018.07.015","article-title":"Cross-sectional investigation and analysis of anxiety and depression in preoperative patients in the outpatient department of aesthetic plastic surgery in a general hospital in China","volume":"71","author":"Wei","year":"2018","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"2026030212063060400_sjaf271-B5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3399\/BJGP12X616481","article-title":"Common mental health disorders\u2013identification and pathways to care: NICE clinical guideline","volume":"62","author":"Kendrick","year":"2012","journal-title":"Br J Gen Pract"},{"key":"2026030212063060400_sjaf271-B6","doi-asserted-by":"publisher","first-page":"387","DOI":"10.3390\/NEUROLINT13030038","article-title":"Selective serotonin reuptake inhibitors and adverse effects: a narrative review","volume":"13","author":"Edinoff","year":"2021","journal-title":"Neurol Int"},{"key":"2026030212063060400_sjaf271-B7","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1002\/OBY.22969","article-title":"Antidepressant medications and weight change: a narrative review","volume":"28","author":"Gill","year":"2020","journal-title":"Obesity"},{"key":"2026030212063060400_sjaf271-B8","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1097\/PRS.0000000000009719","article-title":"Risk factors associated with severe macromastia among adolescents and young women","volume":"150","author":"Massey","year":"2022","journal-title":"Plast Reconstr Surg"},{"key":"2026030212063060400_sjaf271-B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ASJ\/SJAD354","article-title":"Aesthetic plastic surgery national databank statistics 2022","volume":"43","year":"2023","journal-title":"Aesthet Surg J"},{"key":"2026030212063060400_sjaf271-B10","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1097\/PRS.0000000000008312","article-title":"A matched comparison of the benefits of breast reduction on health-related quality of life","volume":"148","author":"Elfanagely","year":"2021","journal-title":"Plast Reconstr Surg"},{"key":"2026030212063060400_sjaf271-B11","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1093\/ASJ\/SJAF113","article-title":"Serotonergic antidepressants and postoperative hematoma risk after abdominoplasty: a study utilizing propensity score matching","volume":"45","author":"Posso","year":"2025","journal-title":"Aesthet Surg J"},{"key":"2026030212063060400_sjaf271-B12","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.bjps.2025.08.025","article-title":"Preoperative use of serotonergic antidepressants is associated with increased rates of complications and surgical revision in autologous breast reconstruction","volume":"110","author":"Dao","year":"2025","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"2026030212063060400_sjaf271-B13","doi-asserted-by":"publisher","first-page":"e886","DOI":"10.1038\/TP.2016.156","article-title":"Endothelial damage in major depression patients is modulated by SSRI treatment, as demonstrated by circulating biomarkers and an in vitro cell model","volume":"6","author":"Lopez-Vilchez","year":"2016","journal-title":"Transl Psychiatry"},{"key":"2026030212063060400_sjaf271-B14","doi-asserted-by":"publisher","first-page":"276","DOI":"10.14744\/TJTES.2020.96892","article-title":"Comparison of pre-operative platelet functions by thromboelastogram in patients selective serotonin reuptake inhibitors user and non-user","volume":"28","author":"Y\u0131lmaz","year":"2022","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"2026030212063060400_sjaf271-B15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jad.2011.08.013","article-title":"Decreased serotonin content and reduced agonist-induced aggregation in platelets of patients chronically medicated with SSRI drugs","volume":"136","author":"Bismuth-Evenzal","year":"2012","journal-title":"J Affect Disord"},{"key":"2026030212063060400_sjaf271-B16","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/J.NEURON.2020.06.002","article-title":"The bidirectional relationship of depression and inflammation: double trouble","volume":"107","author":"Beurel","year":"2020","journal-title":"Neuron"},{"key":"2026030212063060400_sjaf271-B17","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.3390\/NU14091912","article-title":"Sleep quality: a narrative review on nutrition, stimulants, and physical activity as important factors","volume":"14","author":"Sejbuk","year":"2022","journal-title":"Nutrients"},{"key":"2026030212063060400_sjaf271-B18","doi-asserted-by":"publisher","first-page":"3903","DOI":"10.1007\/S00590-024-04069-4","article-title":"Preoperative SSRI use increases perioperative transfusion need in patients undergoing surgical procedures on the hip joint","volume":"34","author":"Hoveidaei","year":"2024","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"2026030212063060400_sjaf271-B19","doi-asserted-by":"publisher","first-page":"e95906","DOI":"10.1371\/JOURNAL.PONE.0095906","article-title":"SSRIs increase risk of blood transfusion in patients admitted for hip surgery","volume":"9","author":"Schutte","year":"2014","journal-title":"PLoS One"},{"key":"2026030212063060400_sjaf271-B20","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1097\/BRS.0000000000005168","article-title":"Serotonergic antidepressants are associated with higher rates of hematoma after anterior cervical spine surgery: a large propensity-matched cohort analysis","volume":"50","author":"Adelstein","year":"2025","journal-title":"Spine (Phila Pa 1976)"},{"key":"2026030212063060400_sjaf271-B21","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1177\/10600280221134108","article-title":"Evaluation of bleeding in orthopedic surgery with perioperative use of serotonergic antidepressants","volume":"57","author":"Yang","year":"2023","journal-title":"Ann Pharmacother"},{"key":"2026030212063060400_sjaf271-B22","doi-asserted-by":"publisher","first-page":"3496","DOI":"10.21037\/JTD.2019.07.76","article-title":"Selective serotonin re-uptake inhibitors: risk of blood product transfusion and inotrope requirements in patients undergoing cardiac surgery","volume":"11","author":"Luzzi","year":"2019","journal-title":"J Thorac Dis"},{"key":"2026030212063060400_sjaf271-B23","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1177\/0267659118765933","article-title":"Do selective serotonin reuptake inhibitors increase the risk of bleeding or mortality following coronary artery bypass graft surgery? A meta-analysis of observational studies","volume":"33","author":"Eckersley","year":"2018","journal-title":"Perfusion"},{"key":"2026030212063060400_sjaf271-B24","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1213\/ANE.0000000000002668","article-title":"Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors are not associated with bleeding or transfusion in cardiac surgical patients","volume":"126","author":"Smith","year":"2018","journal-title":"Anesth Analg"},{"key":"2026030212063060400_sjaf271-B25","doi-asserted-by":"publisher","DOI":"10.1093\/JBCR\/IRAF196","article-title":"Serotonergic antidepressant use after recent facial burn injury is associated with hypertrophic scarring, metabolic complications, and reduced mortality","author":"Dao","year":"2025","journal-title":"J Burn Care Res"},{"key":"2026030212063060400_sjaf271-B26","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3389\/FPHAR.2013.00045","article-title":"Selective serotonin reuptake inhibitor antidepressant treatment discontinuation syndrome: a review of the clinical evidence and the possible mechanisms involved","volume":"4","author":"Renoir","year":"2013","journal-title":"Front Pharmacol"},{"key":"2026030212063060400_sjaf271-B27","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1097\/JCP.0000000000000575","article-title":"Selective serotonin reuptake inhibitors and operative bleeding risk: a review of the literature","volume":"36","author":"Roose","year":"2016","journal-title":"J Clin Psychopharmacol"},{"key":"2026030212063060400_sjaf271-B28","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/j.jpainsymman.2012.08.013","article-title":"Opioid therapies and cytochrome P450 interactions","volume":"44","author":"Gudin","year":"2012","journal-title":"J Pain Symptom Manage"}],"container-title":["Aesthetic Surgery Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/asj\/advance-article-pdf\/doi\/10.1093\/asj\/sjaf271\/66126010\/sjaf271.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/46\/3\/336\/66126010\/sjaf271.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/46\/3\/336\/66126010\/sjaf271.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T17:06:40Z","timestamp":1772471200000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/asj\/article\/46\/3\/336\/8404502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,12,24]]},"published-print":{"date-parts":[[2026,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/asj\/sjaf271","relation":{},"ISSN":["1090-820X","1527-330X"],"issn-type":[{"value":"1090-820X","type":"print"},{"value":"1527-330X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2025,12,24]]}}}