{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:26:24Z","timestamp":1787012784119,"version":"build-2736575974"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Perception studies in aesthetic plastic surgery help define ideals of attractiveness and youth that guide treatment planning. Although comprehensive facial rejuvenation yields superior and longer-lasting results, real-world constraints often require prioritizing interventions. The relative contribution of different facial regions to perceived age remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to determine the relative contributions of the perioral, periocular, midface\u2013lower face, and neck\u2013jawline regions to perceived youth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An aged female 3-dimensional head-and-neck model was digitally sculpted to create 1 baseline young model and 4 variants, each featuring isolated rejuvenation of a single region: eyes, lips, midface\u2013lower face, or neck\u2013jawline. Region-specific changes simulated outcomes of common aesthetic surgical procedures while preserving overall identity. Each variant was rendered as a standardized animated sequence. Participants viewed all animations and ranked them from youngest to oldest. Associations between regions and perceived age were statistically analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 101 participants completed the survey. The neck\u2013jawline was most frequently ranked as youngest (n = 54), whereas the perioral was most often ranked as oldest (n = 71). Mean ranks differed significantly among regions (neck\u2013jawline 1.8, midface\u2013lower face 2.2, periocular 2.6, and perioral 3.6; P &amp;lt; .001). Pairwise comparisons were significant, except between periocular and midface\u2013lower face (P = .4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The neck\u2013jawline exerted the greatest influence on perceived youth, followed by midface\u2013lower face, periocular regions, and perioral region. These findings suggest that structural cues defining facial contour play a dominant role in age perception and may help guide prioritization of facial rejuvenation strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence: 4 (Therapeutic)<\/jats:title>\n                    <jats:p>For image description, please refer to the figure legend and surrounding text.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/asj\/sjag119","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:43:46Z","timestamp":1781783026000},"page":"1022-1028","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Facial Regions on Perceived Age: A 3-Dimensional Modeling Study"],"prefix":"10.1093","volume":"46","author":[{"given":"Francisco 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