{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:32:49Z","timestamp":1791513169566,"version":"4.3.4"},"reference-count":16,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100030838","name":"Merz North America, Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030838","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The d\u00e9collet\u00e9 is susceptible to intrinsic aging, photoaging, and mechanical stress (breast movement and weight), resulting in progressive thinning, laxity, and wrinkle formation. Although injectable fillers are increasingly used to improve d\u00e9collet\u00e9 appearance, controlled clinical data evaluating effectiveness and effects on breast imaging are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the safety and effectiveness of diluted calcium hydroxylapatite carboxymethylcellulose (Radiesse), prepared at a 1:2 ratio with sterile saline, for treating moderate-to-severe d\u00e9collet\u00e9 wrinkles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eligible females were randomized to immediate or delayed treatment. Patients assigned to immediate treatment received up to 3 diluted Radiesse sessions, with optional retreatment. Patients assigned to delayed treatment remained untreated through Week 24 (primary endpoint) and subsequently received the same treatment regimen without retreatment. Effectiveness was assessed by blinded evaluators using the Merz Assessment Scale (MAS) D\u00e9collet\u00e9 Wrinkles\u2014At Rest. Safety evaluations included adverse events, patient-reported treatment responses, and retrospective review of posttreatment radiographic breast imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Week 24 estimated responder rate (\u22651-point improvement on the MAS D\u00e9collet\u00e9 Wrinkles\u2014At Rest) was 71.2% (95% CI, 61.4%-79.4%) among treated patients compared with 6.3% (95% CI, 1.5%-22.9%) among untreated controls, demonstrating a statistically significant between-group difference. Treatment was well tolerated, with predominantly transient, mild-to-moderate injection-site reactions. No interference attributable to diluted Radiesse was observed on posttreatment breast imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diluted Radiesse provided clinically meaningful improvement in d\u00e9collet\u00e9 wrinkles with a favorable safety profile and no observed impact on breast imaging, supporting its use as a nonpermanent injectable option for d\u00e9collet\u00e9 rejuvenation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence: 1 (Therapeutic)<\/jats:title>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/asj\/sjag142","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:49:34Z","timestamp":1783511374000},"source":"Crossref","is-referenced-by-count":1,"title":["Diluted Calcium Hydroxylapatite Carboxymethylcellulose (Radiesse) for D\u00e9collet\u00e9 Wrinkles: Safety and Effectiveness in Adult Females"],"prefix":"10.1093","author":[{"given":"Sabrina","family":"Fabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Moradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Odena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung 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