{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:11:38Z","timestamp":1790100698439,"version":"4.0.1"},"reference-count":80,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Autologous fat grafting (AFG) is increasingly used for aesthetic breast augmentation and remodeling because it provides natural tissue augmentation without permanent implants. This systematic review and meta-analysis evaluated complications, radiologic outcomes, graft retention, and patient satisfaction following AFG. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 compliant search identified 40 primary clinical studies including 5684 patients. The risk of bias was assessed using the RoB2, ROBINS-I, and Newcastle\u2013Ottawa scale. Random-effects meta-analysis used restricted maximum likelihood estimation as the primary model, with Hartung\u2013Knapp adjustment and DerSimonian\u2013Laird and Paule\u2013Mandel estimators in sensitivity analyses. Mean follow-up exceeded 6 months. The pooled complication rate was 25.9% (95% CI, 22.4-29.6), mainly consisting of minor radiologic or palpable findings; fat necrosis was the most common adverse event. Benign radiologic findings included fat necrosis (8.8%) and calcifications (1.1%), without evidence of impaired cancer detection. Mean injected fat volume was 310\u2005mL per breast. Twelve-month volume retention was 61.3% (95% CI, 57.1-65.4), with higher retention in stromal vascular fraction\/platelet-rich plasma\u2013enriched grafts (68.9% vs 56.1%; P &amp;lt; .01), although evidence remained heterogeneous. Patient satisfaction was 93.1% (95% CI, 90.4-95.8), despite heterogeneous PROMs. Heterogeneity was substantial for complications (I2 = 78%; \u03c42 = 0.021; Q = 177.6; P &amp;lt; .001) and volume retention (I2 = 82%; \u03c42 = 0.067; Q = 216.4; P &amp;lt; .001), and moderate for radiologic outcomes (I2 = 52%; \u03c42 = 0.008; Q = 81.3; P &amp;lt; .001), reflecting variability in techniques, imaging, processing, enrichment, assessment methods, and follow-up. Current observational evidence supports favorable safety profiles; however, oncologic outcomes were not quantitatively pooled, and prospective comparative studies with standardized reporting are required.<\/jats:p>\n                  <jats:p>Level of Evidence: 3 (Therapeutic)<\/jats:p>\n                  <jats:p>For image description, please refer to the figure legend and surrounding text.<\/jats:p>","DOI":"10.1093\/asj\/sjag187","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:42:46Z","timestamp":1788522166000},"source":"Crossref","is-referenced-by-count":0,"title":["Autologous Fat Grafting for Breast Augmentation and Breast Remodeling: A Systematic Review and Meta-Analysis of Complications, Radiologic Outcomes, Graft Retention, and Patient-Reported Satisfaction"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3123-3977","authenticated-orcid":false,"given":"Pietro","family":"Gentile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Sterodimas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"2026092213570632700_sjag187-B1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1097\/01.prs.0000252001.59162.c9","article-title":"Fat grafting to the breast revisited: safety and efficacy","volume":"119","author":"Coleman","year":"2007","journal-title":"Plast Reconstr Surg"},{"key":"2026092213570632700_sjag187-B2","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1097\/01.prs.0000438044.06387.2a","article-title":"Megavolume autologous fat transfer: part I. 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