{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T22:12:55Z","timestamp":1766441575289,"version":"3.37.3"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Anaplastic large-cell lymphoma (ALCL) is a very rare but life-threatening complication that has largely been demonstrated to be associated with breast implants (BIA-ALCL). Patients are at risk of BIA-ALCL with the placement of breast implants for either cosmetic or reconstructive purposes, with the highest risks associated with textured breast implants. In the past decade, an increasing number of publications have focused on BIA-ALCL, but there has yet to be a reported case outside of the breast. Here, we describe a unique instance of gluteal implant-associated ALCL (GIA-ALCL) in a middle-aged woman. The patient received bilateral textured silicone gluteal implants only a year prior to her diagnosis of GIA-ALCL. The patient later presented to the Plastic and Reconstructive Surgery Department at our institution with ulceration at the site of her gluteal implants. Unfortunately, her condition deteriorated before explanation could be performed. Biopsy of a left lung mass demonstrated \u201challmark\u201d cells of ALCL (\u201chorseshoe\u201d-shaped nuclei). The diagnosis was verified by immunohistochemical testing that revealed expression of CD30, CD4, CD43, BCL6, Perforin, and Ki67 in a population of abnormal cells. The goals of this case report are thus to demonstrate that all patients undergoing implantation of textured silicone implants are at risk of developing ALCL and to provide evidence for the possible new diagnosis of GIA-ALCL.<\/jats:p>\n               <jats:p>Level of Evidence: 5<\/jats:p>","DOI":"10.1093\/asj\/sjz044","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T12:01:01Z","timestamp":1550232061000},"page":"NP253-NP258","source":"Crossref","is-referenced-by-count":32,"title":["The First Reported Case of Gluteal Implant-Associated Anaplastic Large Cell Lymphoma (ALCL)"],"prefix":"10.1093","volume":"39","author":[{"given":"Orr","family":"Shauly","sequence":"first","affiliation":[{"name":"Keck Hospital of University of Southern California, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J","family":"Gould","sequence":"additional","affiliation":[{"name":"Keck Hospital of University of Southern California, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imran","family":"Siddiqi","sequence":"additional","affiliation":[{"name":"Keck Hospital of University of Southern California, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6883-4816","authenticated-orcid":false,"given":"Ketan M","family":"Patel","sequence":"additional","affiliation":[{"name":"Keck Hospital of University of Southern California, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Carey","sequence":"additional","affiliation":[{"name":"Keck Hospital of University of Southern California, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"issue":"2","key":"2023011307164521900_CIT0001","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/00006534-199708000-00065","article-title":"Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant","volume":"100","author":"Keech","year":"1997","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"2023011307164521900_CIT0002","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/PRS.0b013e318221db81","article-title":"Anaplastic large T-cell lymphoma and breast implants: a review of the literature","volume":"128","author":"Jewell","year":"2011","journal-title":"Plast Reconstr Surg"},{"issue":"5","key":"2023011307164521900_CIT0003","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1097\/PRS.0000000000003282","article-title":"U.S. epidemiology of breast implant-associated anaplastic large cell lymphoma","volume":"139","author":"Doren","year":"2017","journal-title":"Plast Reconstr Surg"},{"issue":"20","key":"2023011307164521900_CIT0004","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"},{"issue":"5","key":"2023011307164521900_CIT0005","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/bjh.14431","article-title":"Targeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK\/STAT signalling pathway genes, TP53 and DNMT3A","volume":"180","author":"Di Napoli","year":"2018","journal-title":"Br J Haematol"},{"issue":"6","key":"2023011307164521900_CIT0006","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1097\/PRS.0000000000002010","article-title":"Bacterial biofilm infection detected in breast implant-associated anaplastic large-cell lymphoma","volume":"137","author":"Hu","year":"2016","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"2023011307164521900_CIT0007","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/PRS.0000000000001033","article-title":"Anaplastic large cell lymphoma occurring in women with breast implants: analysis of 173 cases","volume":"135","author":"Brody","year":"2015","journal-title":"Plast Reconstr Surg"},{"key":"2023011307164521900_CIT0008","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/01.prs.0000388833.98327.6d","article-title":"Anaplastic large cell lymphoma and breast implants? A review of the literature","volume":"126","author":"Maxwell","year":"2010","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"2023011307164521900_CIT0009","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/PRS.0000000000003654","article-title":"Breast implant-associated anaplastic large cell lymphoma in Australia and New Zealand: high-surface-area textured implants are associated with increased risk","volume":"140","author":"Loch-Wilkinson","year":"2017","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"2023011307164521900_CIT0010","doi-asserted-by":"crossref","first-page":"610e","DOI":"10.1097\/PRS.0b013e3182450aae","article-title":"Anaplastic large cell lymphoma and breast implants: five Australian cases","volume":"129","author":"Taylor","year":"2012","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"2023011307164521900_CIT0011","doi-asserted-by":"crossref","first-page":"586e","DOI":"10.1097\/PRS.0000000000004262","article-title":"How to diagnose and treat breast implant-associated anaplastic large cell lymphoma","volume":"141","author":"Clemens","year":"2018","journal-title":"Plast Reconstr Surg"},{"issue":"17","key":"2023011307164521900_CIT0012","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1001\/jama.2008.585","article-title":"Anaplastic large-cell lymphoma in women with breast implants","volume":"300","author":"de Jong","year":"2008","journal-title":"JAMA"},{"issue":"11","key":"2023011307164521900_CIT0013","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.3109\/10428194.2016.1160079","article-title":"Marked eosinophilia as initial presentation of breast implant-associated anaplastic large cell lymphoma","volume":"57","author":"Orofino","year":"2016","journal-title":"Leuk Lymphoma"},{"issue":"4","key":"2023011307164521900_CIT0014","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/modpathol.3801024","article-title":"Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder","volume":"21","author":"Roden","year":"2008","journal-title":"Mod Pathol"}],"container-title":["Aesthetic Surgery Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/39\/7\/NP253\/48686890\/sjz044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/39\/7\/NP253\/48686890\/sjz044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T07:18:49Z","timestamp":1673594329000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/asj\/article\/39\/7\/NP253\/5320439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,15]]},"references-count":14,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,2,15]]},"published-print":{"date-parts":[[2019,6,21]]}},"URL":"https:\/\/doi.org\/10.1093\/asj\/sjz044","relation":{},"ISSN":["1090-820X","1527-330X"],"issn-type":[{"type":"print","value":"1090-820X"},{"type":"electronic","value":"1527-330X"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,2,15]]}}}