{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:03:56Z","timestamp":1788627836175,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Moss SpA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Breast augmentation-mastopexy can yield an aesthetically attractive breast, but the 1-stage procedure is prone to unsatisfactory outcomes, including poor wound healing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The authors evaluated whether postsurgical application of a polyurethane bra cup coated with oxygen-enriched olive oil (NovoX Cup; Moss SpA, Lesa, Novara, Italy) would decrease pain associated with augmentation-mastopexy and improve the quality of the surgical scar.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective study was conducted at a single center from January 2016 to June 2019. All patients underwent 1-stage augmentation-mastopexy with the inverted T incision. For 2 weeks postsurgically, wounds were dressed either with the oxygen-enriched olive oil bra or with Fitostimoline (Farmaceutici Damor SpA, Naples, Italy). Patients indicated their pain intensity on postoperative days 2, 3, and 10, and patients and independent observers scored scar quality on the Patient and Observer Scar Assessment Scale (POSAS) 6 and 12 months after the procedure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 240 women (120 per study arm) completed the study. All the patients had satisfactory aesthetic results, and there were no tolerability concerns with either postoperative dressing. Compared with patients in the Fitostimoline group, patients who received the oxygen-enriched olive oil bra cup had significantly lower pain levels, and their surgical scars were given better scores on the POSAS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results suggest that maintenance of the surgical wound in a film of oxygen-enriched olive oil for 2 weeks is a safe, effective modality for suppressing pain and promoting healing following augmentation-mastopexy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Level of Evidence: 2<\/jats:title>\n                  <jats:p\/>\n               <\/jats:sec>","DOI":"10.1093\/asjof\/ojab016","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T03:06:37Z","timestamp":1620097597000},"source":"Crossref","is-referenced-by-count":11,"title":["Treatment With Oxygen-Enriched Olive Oil Improves Healing Parameters Following Augmentation-Mastopexy"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0500-461X","authenticated-orcid":false,"given":"Adriano","family":"Santorelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bernini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Orzalesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6002-6454","authenticated-orcid":false,"given":"Stefano","family":"Avvedimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Kothari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9700-1648","authenticated-orcid":false,"given":"Alfonso","family":"Fausto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Magalotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Buzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sandroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Calabrese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"issue":"3","key":"2024030201134610300_CIT0001","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/01.PRS.0000072257.66189.3E","article-title":"Augmentation\/mastopexy: \u201csurgeon, beware\u201d","volume":"112","author":"Spear","year":"2003","journal-title":"Plast Reconstr Surg."},{"issue":"2","key":"2024030201134610300_CIT0002","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00266-011-9796-7","article-title":"Simultaneous augmentation mastopexy: a technique for maximum en bloc skin resection using the inverted-T pattern regardless of implant size, asymmetry, or ptosis","volume":"36","author":"Eisenberg","year":"2012","journal-title":"Aesthetic Plast Surg."},{"issue":"5","key":"2024030201134610300_CIT0003","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1097\/PRS.0000000000000582","article-title":"A systematic review of single-stage augmentation-mastopexy","volume":"134","author":"Khavanin","year":"2014","journal-title":"Plast Reconstr Surg."},{"issue":"1","key":"2024030201134610300_CIT0004","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00266-019-01557-5","article-title":"Bleeding in plastic-aesthetic surgery: a prognostic pathway with clinical application","volume":"44","author":"Marlino","year":"2020","journal-title":"Aesthetic Plast Surg."},{"issue":"6","key":"2024030201134610300_CIT0005","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.asj.2006.10.003","article-title":"Is one-stage breast augmentation with mastopexy safe and effective? A review of 186 primary cases","volume":"26","author":"Stevens","year":"2006","journal-title":"Aesthet Surg J."},{"issue":"9","key":"2024030201134610300_CIT0006","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1097\/GOX.0000000000000034","article-title":"Comparison of vertical and inverted-T mammaplasties using photographic measurements","volume":"1","author":"Swanson","year":"2013","journal-title":"Plast Reconstr Surg Glob Open."},{"issue":"5","key":"2024030201134610300_CIT0007","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1177\/1090820X14531434","article-title":"One-stage augmentation mastopexy: a review of 1192 simultaneous breast augmentation and mastopexy procedures in 615 consecutive patients","volume":"34","author":"Stevens","year":"2014","journal-title":"Aesthet Surg J."},{"issue":"2","key":"2024030201134610300_CIT0008","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1365-2133.2010.09804.x","article-title":"Oxygen in acute and chronic wound healing","volume":"163","author":"Schreml","year":"2010","journal-title":"Br J Dermatol."},{"issue":"8","key":"2024030201134610300_CIT0009","first-page":"264","article-title":"The presence of oxygen in wound healing","volume":"28","author":"Kimmel","year":"2016","journal-title":"Wounds."},{"issue":"1","key":"2024030201134610300_CIT0010","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/sj.jidsymp.5650001","article-title":"Reactive oxygen species and their detoxification in healing skin wounds","volume":"11","author":"auf dem Keller","year":"2006","journal-title":"J Investig Dermatol Symp Proc."},{"issue":"1","key":"2024030201134610300_CIT0011","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/iwj.12557","article-title":"Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process","volume":"14","author":"Dunnill","year":"2017","journal-title":"Int Wound J."},{"issue":"6","key":"2024030201134610300_CIT0012","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1365-2133.2005.06939.x","article-title":"The dual action of ozone on the skin","volume":"153","author":"Valacchi","year":"2005","journal-title":"Br J Dermatol."},{"issue":"3","key":"2024030201134610300_CIT0013","first-page":"67","article-title":"Studies on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone","volume":"12","author":"Bocci","year":"1998","journal-title":"J Biol Regul Homeost Agents."},{"issue":"1","key":"2024030201134610300_CIT0014","first-page":"25","article-title":"The therapeutic effect of ozonated olive oil plus glucantime on human cutaneous leishmaniasis","volume":"22","author":"Aghaei","year":"2019","journal-title":"Iran J Basic Med Sci."},{"issue":"1","key":"2024030201134610300_CIT0015","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1590\/S0103-64402011000100006","article-title":"Ozonized oils: a qualitative and quantitative analysis","volume":"22","author":"Guinesi","year":"2011","journal-title":"Braz Dent J."},{"issue":"2","key":"2024030201134610300_CIT0016","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.chemphyslip.2007.10.004","article-title":"Characterization of ozonated vegetable oils by spectroscopic and chromatographic methods","volume":"151","author":"Sadowska","year":"2008","journal-title":"Chem Phys Lipids."},{"issue":"2","key":"2024030201134610300_CIT0017","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10151-015-1404-4","article-title":"Treatment of minor dehiscence after endorectal advancement flap in perianal Crohn\u2019s fistulas with ozonized oil NOVOX(\u00ae)","volume":"20","author":"Laureti","year":"2016","journal-title":"Tech Coloproctol."},{"key":"2024030201134610300_CIT0018","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.12968\/gasn.2020.18.Sup4.S23","article-title":"Reactive oxygen species in an oleic matrix for healing deep and narrow wounds: a case series","volume":"18","author":"Giulia","year":"2020","journal-title":"Gastrointest Nurs"},{"issue":"2","key":"2024030201134610300_CIT0019","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0094-1298(20)30220-0","article-title":"Breast ptosis. Definition and treatment","volume":"3","author":"Regnault","year":"1976","journal-title":"Clin Plast Surg."},{"key":"2024030201134610300_CIT0020","first-page":"3","article-title":"An Indian clinical trial to assess wound healing activity and safety of Fitostimoline\u00ae 15%+1% cream as topical treatment of different type of wounds","volume":"6","author":"Chaturvedi","year":"2010","journal-title":"J Plast Dermatology"},{"issue":"12","key":"2024030201134610300_CIT0021","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1093\/asj\/sjz006","article-title":"The tissue-based triad in augmentation mastopexy: single-stage technical refinements","volume":"39","author":"Sanniec","year":"2019","journal-title":"Aesthet Surg J."},{"issue":"3","key":"2024030201134610300_CIT0022","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/PRS.0000000000003575","article-title":"Macrotextured breast implants with defined steps to minimize bacterial contamination around the device: experience in 42,000 implants","volume":"140","author":"Adams","year":"2017","journal-title":"Plast Reconstr Surg."},{"issue":"2","key":"2024030201134610300_CIT0023","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00266-018-1291-y","article-title":"Standardized practice reduces complications in breast augmentation: results with the first 290 consecutive cases versus non-standardized comparators","volume":"43","author":"Santorelli","year":"2019","journal-title":"Aesthetic Plast Surg."},{"issue":"7","key":"2024030201134610300_CIT0024","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1097\/01.PRS.0000122207.28773.56","article-title":"The patient and observer scar assessment scale: a reliable and feasible tool for scar evaluation","volume":"113","author":"Draaijers","year":"2004","journal-title":"Plast Reconstr Surg."},{"issue":"2","key":"2024030201134610300_CIT0025","doi-asserted-by":"crossref","DOI":"10.22237\/jmasm\/1320120120","article-title":"Type I error rates of the two-sample pseudo-median procedure","volume":"10","author":"Ahad","year":"2011","journal-title":"J Mod Appl Stat Methods"},{"key":"2024030201134610300_CIT0026","article-title":"Patient satisfaction following inverted-T and short-scar mammoplasty as measured by the Breast Evaluation Questionnaire 55","author":"Pontes","year":"2020","journal-title":"Aesthet Surg J"},{"issue":"11","key":"2024030201134610300_CIT0027","first-page":"e1103","article-title":"Evaluation of the antibacterial activity of a new ozonized olive oil against oral and periodontal pathogens","volume":"10","author":"Pietrocola","year":"2018","journal-title":"J Clin Exp Dent."},{"issue":"1","key":"2024030201134610300_CIT0028","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/0976-237X.177097","article-title":"Efficacy of ozonized olive oil in the management of oral lesions and conditions: a clinical trial","volume":"7","author":"Kumar","year":"2016","journal-title":"Contemp Clin Dent."},{"issue":"3","key":"2024030201134610300_CIT0029","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000336889","article-title":"Cytological assessment of healing palatal donor site wounds and grafted gingival wounds after application of ozonated oil: an eighteen-month randomized controlled clinical trial","volume":"56","author":"Patel","year":"2012","journal-title":"Acta Cytol."},{"issue":"4","key":"2024030201134610300_CIT0030","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.2041-1626.2011.00072.x","article-title":"Therapeutic effect of topical ozonated oil on the epithelial healing of palatal wound sites: a planimetrical and cytological study","volume":"2","author":"Patel","year":"2011","journal-title":"J Investig Clin Dent."},{"issue":"2","key":"2024030201134610300_CIT0031","first-page":"2449","article-title":"The antibacterial effect of topical ozone on the treatment of MRSA skin infection","volume":"17","author":"Song","year":"2018","journal-title":"Mol Med Rep."},{"issue":"6","key":"2024030201134610300_CIT0032","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3919\/jjsa.61.1383","article-title":"Therapeutic effects of ozonized olive oil in the treatment of intractable fistula and wound after surgical operation","volume":"61","author":"Akiyo","year":"2000","journal-title":"J Jpn Surg Assoc"},{"issue":"2","key":"2024030201134610300_CIT0033","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s00266-019-01540-0","article-title":"Short-scar augmentation mastopexy in massive-weight loss patients: four-step surgical principles for reliable and reproducible results","volume":"44","author":"Salgarello","year":"2020","journal-title":"Aesthetic Plast Surg."},{"issue":"6","key":"2024030201134610300_CIT0034","first-page":"461","article-title":"Scar wars","volume":"24","author":"Nahai","year":"2000","journal-title":"Aesthetic Plast Surg."},{"issue":"7","key":"2024030201134610300_CIT0035","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1097\/01.prs.0000248397.83578.aa","article-title":"Mastopexy preferences: a survey of board-certified plastic surgeons","volume":"118","author":"Rohrich","year":"2006","journal-title":"Plast Reconstr Surg."},{"key":"2024030201134610300_CIT0036","doi-asserted-by":"crossref","first-page":"610418","DOI":"10.1155\/2010\/610418","article-title":"Ozone and ozonated oils in skin diseases: a review","volume":"2010","author":"Travagli","year":"2010","journal-title":"Mediators Inflamm."},{"issue":"7055","key":"2024030201134610300_CIT0037","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/437045a","article-title":"Phytochemistry: ibuprofen-like activity in extra-virgin olive oil","volume":"437","author":"Beauchamp","year":"2005","journal-title":"Nature."},{"issue":"2","key":"2024030201134610300_CIT0038","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/PRS.0b013e3181de24bc","article-title":"Identifying and avoiding bias in research","volume":"126","author":"Pannucci","year":"2010","journal-title":"Plast Reconstr Surg."},{"issue":"5","key":"2024030201134610300_CIT0039","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/17460441.2019.1588879","article-title":"The discovery and development of topical medicines for wound healing","volume":"14","author":"\u00d6hnstedt","year":"2019","journal-title":"Expert Opin Drug Discov."}],"container-title":["Aesthetic Surgery Journal Open Forum"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/asjopenforum\/advance-article-pdf\/doi\/10.1093\/asjof\/ojab016\/37781611\/ojab016.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asjopenforum\/article-pdf\/3\/3\/ojab016\/56817436\/ojab016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asjopenforum\/article-pdf\/3\/3\/ojab016\/56817436\/ojab016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T01:14:54Z","timestamp":1709342094000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/asjopenforum\/article\/doi\/10.1093\/asjof\/ojab016\/6263445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,4]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/asjof\/ojab016","relation":{},"ISSN":["2631-4797"],"issn-type":[{"value":"2631-4797","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,9,1]]},"published":{"date-parts":[[2021,5,4]]},"article-number":"ojab016"}}