{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:41:59Z","timestamp":1753875719057,"version":"3.41.2"},"reference-count":28,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":158,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"LABORATOIRES VIVACY"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surgical treatment of cleft lip and palate is divided into primary and secondary procedures to restore physiological function and appearance of the face, mouth, and nose. Hyaluronic acid (HA) bio-implants have been successfully used for volume loss correction in several medical disciplines. However, there is paucity of information about its use in the management of facial clefting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this report is to present the preliminary findings on the feasibility of using a cross-linked HA for aesthetic correction in previously surgical treated cleft lip and palate cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cross-linked HA STYLAGE L, XL, and XXL (LABORATOIRES VIVACY, Paris, France) were used in this case series. Multiple treatment sessions, 4-6 weeks apart, were performed if required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15 patients had undergone the HA injections between May 2018 and December 2021. Of these, 13 had simultaneous correction of the nose, lip, and paranasal scar and the remaining 2 only the lip and scar. The procedures were uneventful and well tolerated by the patients. At follow-up, aesthetic improvement was observed in all patients. Moreover, patients reported overall satisfaction with the outcome of the procedures particularly because of its minimally invasive nature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cross-linked HA is a feasible and promising complimentary option for aesthetic, and potentially functional, correction in cases of cleft lip and palate. Larger clinical trials are needed to validate these preliminary findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence: 4<\/jats:title><jats:p\/><\/jats:sec>","DOI":"10.1093\/asjof\/ojac052","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T22:10:30Z","timestamp":1654726230000},"source":"Crossref","is-referenced-by-count":4,"title":["Cross-Linked Hyaluronic Acid for Cleft Lip and Palate Aesthetic Correction: A Preliminary Report"],"prefix":"10.1093","volume":"4","author":[{"given":"\u0141ukasz","family":"Ordynowski","sequence":"first","affiliation":[{"name":"aesthetic practitioner in private practice Dr Ordynowski is an , Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"issue":"4","key":"2023021307250042200_CIT0001","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1597\/07-230.1","article-title":"Clefts of the secondary palate referred to the Oslo cleft team: epidemiology and cleft severity in 994 individuals","volume":"47","author":"Andersson","year":"2010","journal-title":"Cleft Palate-Craniofac J."},{"key":"2023021307250042200_CIT0002","first-page":"1","volume-title":"Global Registry and Database on Craniofacial Anomalies: Report of a WHO Registry Meeting on Craniofacial Anomalies","author":"Mossey","year":"2003"},{"key":"2023021307250042200_CIT0003","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195139068.001.0001","volume-title":"Cleft Lip and Palate: From Origin to Treatment","author":"Wyszynski","year":"2002"},{"issue":"3","key":"2023021307250042200_CIT0004","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat Rev Genet."},{"volume-title":"Oral Anatomy, Histology and Embryology","year":"2009","author":"Berkowitz","key":"2023021307250042200_CIT0005"},{"issue":"7453","key":"2023021307250042200_CIT0006","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1136\/bmj.38106.559120.7C","article-title":"Long term follow up study of survival associated with cleft lip and palate at birth","volume":"328","author":"Christensen","year":"2004","journal-title":"Br Med J."},{"issue":"10","key":"2023021307250042200_CIT0007","first-page":"899","article-title":"Wp\u0142yw wczesnej rekonstrukcji podniebienia na rozw\u00f3j systemu fonetycznego dzieci z rozszczepem podniebienia","volume":"80","author":"Hortis-Dzierzbicka","year":"2005","journal-title":"Pediatr Pol."},{"volume-title":"Rozszczepy wargi i podniebienia","year":"2007","author":"Matthews-Brzozowska","key":"2023021307250042200_CIT0008"},{"issue":"1","key":"2023021307250042200_CIT0009","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/0970-0358.96590","article-title":"Nasomaxillary complex in size, position and orientation in surgically treated and untreated individuals with cleft lip and palate: a cephalometric overview","volume":"45","author":"Khanna","year":"2012","journal-title":"Indian J Plast Surg."},{"issue":"4","key":"2023021307250042200_CIT0010","first-page":"311","article-title":"Effects of cleft lip and palate on children\u2019s psychological health: a systematic review","volume":"13","author":"Al-Namankany","year":"2018","journal-title":"J Taibah Univ Med Sci."},{"issue":"4","key":"2023021307250042200_CIT0011","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4103\/0971-9261.102333","article-title":"Outcome analysis of palatoplasty in various types of cleft palate","volume":"17","author":"Annigeri","year":"2012","journal-title":"J Indian Assoc Pediatr Surg."},{"issue":"7","key":"2023021307250042200_CIT0012","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1601-0825.2009.01577.x","article-title":"The genetics of isolated orofacial clefts: from genotypes to subphenotypes","volume":"15","author":"Jugessur","year":"2009","journal-title":"Oral Dis."},{"issue":"1","key":"2023021307250042200_CIT0013","first-page":"439","article-title":"Interdisciplinary treatment of cleft lip and\/or palate\u2014state of the art","volume":"48","author":"Hortis-Dzierzbicka","year":"2019","journal-title":"Logopedia."},{"issue":"2","key":"2023021307250042200_CIT0014","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4103\/0970-0358.118591","article-title":"Unfavourable results in the repair of the cleft lip","volume":"46","author":"Narayanan","year":"2013","journal-title":"Indian J Plast Surg."},{"issue":"1","key":"2023021307250042200_CIT0015","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1597\/1545-1569_2001_038_0068_dccfaa_2.0.co_2","article-title":"Different cleft conditions, facial appearance, and speech: relationship to psychological variables","volume":"38","author":"Millard","year":"2001","journal-title":"Cleft Palate-Craniofacial J."},{"issue":"1","key":"2023021307250042200_CIT0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0007-1226(97)91275-3","article-title":"Psychological outcomes amongst cleft patients and their families","volume":"50","author":"Turner","year":"1997","journal-title":"Br J Plast Surg"},{"issue":"3","key":"2023021307250042200_CIT0017","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/00001665-200405000-00027","article-title":"Augmentation by autologous adipose tissue in cleft lip and nose. Final esthetic touches in clefts: part I","volume":"15","author":"Duskova","year":"2004","journal-title":"J Craniofac Surg."},{"issue":"2","key":"2023021307250042200_CIT0018","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.bjps.2003.11.007","article-title":"Free dermis-fat graft to correct the whistle deformity in patients with cleft lip","volume":"57","author":"Patel","year":"2004","journal-title":"Br J Plast Surg."},{"issue":"12","key":"2023021307250042200_CIT0019","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.bjps.2014.08.049","article-title":"Immediate fat grafting in primary cleft lip repair","volume":"67","author":"Balkin","year":"2014","journal-title":"J Plast Reconstr Aesthetic Surg."},{"issue":"5","key":"2023021307250042200_CIT0020","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1097\/PRS.0000000000001187","article-title":"Fat grafting in primary cleft lip repair","volume":"135","author":"Zellner","year":"2015","journal-title":"Plast Reconstr Surg."},{"key":"2023021307250042200_CIT0021","doi-asserted-by":"crossref","first-page":"109692","DOI":"10.1016\/j.ijporl.2019.109692","article-title":"Lipofilling in patients with a cleft lip (and palate)\u2014a pilot study assessing functional outcomes and patients\u2019 satisfaction with appearance","volume":"128","author":"Alighieri","year":"2020","journal-title":"Int J Pediatr Otorhinolaryngol."},{"issue":"3","key":"2023021307250042200_CIT0022","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1468-3083.2004.01180.x","article-title":"Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin","volume":"19","author":"Brown","year":"2005","journal-title":"J Eur Acad Dermatol Venereol."},{"issue":"Supplement_1","key":"2023021307250042200_CIT0023","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0151-9638(10)70002-8","article-title":"Hyaluronic acid and extracellular matrix: a primitive molecule?","volume":"137","author":"Nusgens","year":"2010","journal-title":"Ann Dermatol Venereol"},{"issue":"3","key":"2023021307250042200_CIT0024","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3889\/oamjms.2015.067","article-title":"The surgical lips deformity corrected with hyaluronic fillers: a case report","volume":"3","author":"Stolic","year":"2015","journal-title":"Maced J Med Sci."},{"issue":"5","key":"2023021307250042200_CIT0025","first-page":"717","article-title":"Successful treatment with injected hyaluronic acid in a patient with lip asymmetry after surgical correction of cleft lip","volume":"34","author":"Schweiger","year":"2008","journal-title":"Dermatol Surg."},{"key":"2023021307250042200_CIT0026","doi-asserted-by":"crossref","first-page":"ojac035","DOI":"10.1093\/asjof\/ojac035","article-title":"Ethnicity and non-surgical rhinoplasty","volume":"4","author":"Ziade","year":"2022","journal-title":"Aesthet Surg J Open Forum."},{"issue":"2","key":"2023021307250042200_CIT0027","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.otc.2019.12.001","article-title":"Concepts of facial aesthetics when considering ethnic rhinoplasty","volume":"53","author":"Patel","year":"2020","journal-title":"Otolaryngol Clin North Am."},{"issue":"4","key":"2023021307250042200_CIT0028","first-page":"205","article-title":"The use of preparations with hyaluronic acid in correction cleft lip and palate. Preliminary report","volume":"4","author":"Ordynowski","year":"2021","journal-title":"Med Funkcjonalna Estetyka Lek."}],"container-title":["Aesthetic Surgery Journal Open Forum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/asjopenforum\/advance-article-pdf\/doi\/10.1093\/asjof\/ojac052\/43984729\/ojac052.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asjopenforum\/article-pdf\/doi\/10.1093\/asjof\/ojac052\/49164794\/ojac052.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asjopenforum\/article-pdf\/doi\/10.1093\/asjof\/ojac052\/49164794\/ojac052.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T21:23:10Z","timestamp":1700688190000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/asjopenforum\/article\/doi\/10.1093\/asjof\/ojac052\/6604465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":28,"URL":"https:\/\/doi.org\/10.1093\/asjof\/ojac052","relation":{},"ISSN":["2631-4797"],"issn-type":[{"type":"electronic","value":"2631-4797"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2022,1,1]]},"article-number":"ojac052"}}