{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:47:06Z","timestamp":1782460026622,"version":"3.54.5"},"reference-count":16,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The 1550\u2005nm nonablative fractional laser (NAFL) is a well-established and versatile technology in aesthetic dermatology, offering a minimally invasive solution for improvements in skin quality. In this study, the authors introduce a novel NAFL, MOSAIC 3-Dimensional Controlled Chaos Technology (3D CCT), engineered to enhance treatment efficacy and safety. The aim of the authors of this report is to evaluate the safety and efficacy of MOSAIC 3D CCT for facial rejuvenation using patient-reported outcomes, blinded expert assessments, and objective imaging analyses. A retrospective analysis was conducted on 14 patients, aged 34 to 73 years, with Fitzpatrick skin phototypes II to V, who underwent 3 sessions of NAFL treatment for facial rejuvenation at 1- to 2-month intervals. Outcomes were evaluated using the Scientific Assessment Scale of Skin Quality (SASSQ), quantitative analysis with LifeViz imaging software, and the FACE-Q questionnaire. SASSQ analysis showed a trend toward improvement, though none of the changes reached statistical significance (P &amp;gt; .05). LifeViz analysis demonstrated improvement in all 5 domains, with statistical significance reached only for wrinkle reduction (P \u2264 .05). FACE-Q analysis revealed statistically significant improvements across all 12 patient-reported domains (P &amp;lt; .05), including clarity, smoothness, radiance, and overall satisfaction. Transient edema and erythema occurred in all patients and resolved within 48\u2005hours. No severe adverse effects, including postinflammatory erythema or hyperpigmentation, were reported. Within the limitations of this small retrospective study, MOSAIC 3D CCT demonstrated potential to improve facial skin quality with a favorable safety profile. Larger prospective studies are needed to confirm these preliminary findings.<\/jats:p>\n                  <jats:p>Level of Evidence: 4 (Therapeutic)<\/jats:p>\n                  <jats:p\/>","DOI":"10.1093\/asjof\/ojaf134","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:16:19Z","timestamp":1760703379000},"source":"Crossref","is-referenced-by-count":0,"title":["Optimizing Nonablative Fractional Laser Treatment: Clinical Evaluation of a Novel 3-Dimentional Controlled Chaos Technology"],"prefix":"10.1093","volume":"8","author":[{"given":"Guy","family":"Erlich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-9967","authenticated-orcid":false,"given":"Ron","family":"Skorochod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliran","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-510X","authenticated-orcid":false,"given":"Yoram","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,18]]},"reference":[{"key":"2026062603024649800_ojaf134-B1","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1111\/j.1524-4725.2005.31931","article-title":"Nonablative remodeling with a 1,540 nm erbium:glass 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