{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T11:51:44Z","timestamp":1765972304448,"version":"3.48.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":330,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyaluronic acid (HA) fillers are among the most widely used aesthetic treatments, valued for their safety, biocompatibility, and reversibility. Product-specific adverse events (AEs) are important to understand, especially delayed AEs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the incidence, severity, and risk factors of AEs following nasolabial fold (NLF) treatment with CPM-B (cohesive polydensified matrix hyaluronic acid filler with 22.5\u2005mg\/ml HA; Belotero Balance\u00ae; Anteis S.A., Switzerland) across 5 internal clinical studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pooled data included treatments to 526 NLFs in 412 patients. Adverse events were categorized into 12 subtypes and rated as mild, moderate, or severe. Multivariable logistic regression was used to evaluate the independent association of patient (age, sex) and procedure-related factors (injection volume, NLF laterality) with AE risk (\u22651 vs 0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adverse events were observed in 41% of treated NLFs; the majority (97%) were mild, with no severe AEs documented. The most common AEs included swelling (23%), erythema (20%), and bruising\/ecchymosis (17%). Adverse event risk significantly increased with injection volume; every additional 100\u2005\u00b5l raised the odds of an AE by 2.38 (P = .00537). Patient age, sex, and NLF laterality were not significantly associated with AE risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study supports the overall safety and tolerability of CPM-B, with most AEs being mild and transient; only 3.8% were moderate, and none were severe. When controlling for study, volume was the only significant predictor of AE risk, highlighting the need for physicians to minimize excessive volumes where possible. Future studies should explore AE predictors in more diverse populations and investigate additional risk factors to optimize safety and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence: 3 (Risk)<\/jats:title>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/asjof\/ojaf151","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:04:27Z","timestamp":1763643867000},"source":"Crossref","is-referenced-by-count":0,"title":["The Balance of Beauty: Pooled Analysis of Adverse Events With a Cohesive Polydensified Matrix-Hyaluronic Acid Filler in Nasolabial Fold Treatments"],"prefix":"10.1093","volume":"7","author":[{"given":"Sonja","family":"Sattler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korin","family":"Leffler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanti","family":"Galloway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi R","family":"Borrelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"author":"(ISAPS) ISoAPS","key":"2025121706220359000_ojaf151-B1"},{"key":"2025121706220359000_ojaf151-B2","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/DSS.0000000000003350","article-title":"Postmarket safety surveillance of delayed complications for recent FDA-approved hyaluronic acid dermal fillers","volume":"48","author":"Cohen","year":"2022","journal-title":"Dermatologic Surgery"},{"key":"2025121706220359000_ojaf151-B3","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2147\/CCID.S50546","article-title":"Dermal fillers in aesthetics: an overview of adverse events and treatment approaches","volume":"6","author":"Funt","year":"2013","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2025121706220359000_ojaf151-B4","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.det.2004.09.009","article-title":"The evolution of soft tissue fillers in clinical practice","volume":"23","author":"Murray","year":"2005","journal-title":"Dermatol Clin"},{"key":"2025121706220359000_ojaf151-B5","doi-asserted-by":"publisher","first-page":"357","DOI":"10.5021\/ad.2014.26.3.357","article-title":"Investigation of the degradation-retarding effect caused by the low swelling capacity of a novel hyaluronic acid filler developed by solid-phase crosslinking technology","volume":"26","author":"Park","year":"2014","journal-title":"Ann Dermatol. 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