{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T14:58:14Z","timestamp":1783090694148,"version":"3.54.6"},"reference-count":10,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":53,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Botulinum toxin type A (BoNT-A) is widely used in therapeutic and cosmetic settings for neuromuscular and aesthetic indications. Although generally well tolerated, reports of hypersensitivity reactions\u2014ranging from localized erythema to systemic immune syndromes\u2014underscore its immunological complexity. This case report and literature review demonstrates a novel case of serum sickness following cosmetic Botox\u00ae (onabotulinumtoxin-A, Allergan Aesthetics, an AbbVie company, Irvine, CA) administration, categorizes hypersensitivity reactions according to the Gell and Coombs classification (Types I\u2013IV), explores the role of complexing proteins and formulation excipients, and highlights emerging clinical concerns. This will underscore the need for greater vigilance in identifying systemic immune responses to BoNT-A especially within the cosmetic medicine industry.<\/jats:p>\n                  <jats:p>Level of Evidence: 5 (Therapeutic)<\/jats:p>\n                  <jats:p\/>","DOI":"10.1093\/asjof\/ojag027","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:39:47Z","timestamp":1771591187000},"source":"Crossref","is-referenced-by-count":1,"title":["Serum Sickness After Cosmetic Botulinum Toxin Type A Injections"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8481-9512","authenticated-orcid":false,"given":"Danielle","family":"DeLuca-Pytell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Dass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Audia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Busuito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"2026041703414123600_ojag027-B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/asj\/sjae188","article-title":"Aesthetic plastic surgery national databank statistics 2023","volume":"44","year":"2024","journal-title":"Aesthet Surg 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reporting system","volume":"16","author":"Nicoletti","year":"2023","journal-title":"Pharmaceuticals (Basel)"}],"container-title":["Aesthetic Surgery Journal Open 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