{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:06:55Z","timestamp":1785146815901,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":197,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100032817","name":"Professional Dietetics S.p.A.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Edematous fibrosclerotic panniculopathy (EFP) affects \u223c80% to 98% of postpubertal women and has a significant impact on quality of life. Its unclear etiopathology and the multifactorial origin pose a significant challenge for its clinical management. This study aimed to evaluate the efficacy and the safety of a commercially available mixture of hyaluronic acid and amino acids in an alkaline solution. A prospective multicenter clinical trial was carried out on 46 women with EFP Stage I to early Stage IV. The improvement of cellulite severity was evaluated by the modified Clinician-Reported Photonumeric Cellulite Severity Scale (CR-PCSS) and the modified Patient-Reported PCSS (PR-PCSS) before the first (T1), the second (T2), and the third injection (T3) and after 3 (T4) and 6 (T5) months of treatment. The psychological impact of cellulite was measured using the Objectified Body Consciousness (OBC) scale. The PR-PCSS revealed that 95.3% of participants reported an improvement in their appearance. These positive outcomes remained consistent up to 6 months following the initial treatment. Similarly, the CR-PCSS showed that as early as 2 weeks after the first treatment, 76.7% of participants demonstrated objective improvement based on the Global Aesthetic Improvement Scale. These improvements also remained stable for up to 6 months. Self-esteem (OBC scale) was improved. No major adverse events were reported; minor bruising occurred as expected because of injections. Sunekos Cell 15 is a possibly effective and well-tolerated treatment for cellulite, particularly in cases with pronounced fibrosis, potentially offering a minimally invasive therapeutic option.<\/jats:p>\n                  <jats:p>Level of Evidence: 4 (Therapeutic)<\/jats:p>\n                  <jats:p>For image description, please refer to the figure legend and surrounding text.<\/jats:p>","DOI":"10.1093\/asjof\/ojag137","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:47:35Z","timestamp":1784202455000},"source":"Crossref","is-referenced-by-count":0,"title":["An Innovative Injection Technique for Treating Edematous Fibrosclerotic Panniculopathy (Cellulite): A Prospective Multicenter Clinical Investigation"],"prefix":"10.1093","volume":"8","author":[{"given":"Elena","family":"Fasola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Boca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Reggiardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9147-302X","authenticated-orcid":false,"given":"Vincenzo","family":"Nobile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhouha","family":"Dridi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"2026072705365544300_ojag137-B1","doi-asserted-by":"publisher","DOI":"10.1093\/asjof\/ojad050","article-title":"Cellulite: current understanding and treatment","volume":"5","author":"Gabriel","year":"2023","journal-title":"Aesthet Surg J Open Forum"},{"key":"2026072705365544300_ojag137-B2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1046\/j.1468-3083.2000.00016.x","article-title":"Cellulite: a review","volume":"14","author":"Rossi","year":"2000","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2026072705365544300_ojag137-B3","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1097\/DSS.0000000000003745","article-title":"Cellulite pathophysiology and psychosocial implications","volume":"49","author":"Bass","year":"2023","journal-title":"Dermatol Surg"},{"key":"2026072705365544300_ojag137-B4","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2147\/CCID.S95830","article-title":"Cellulite: a review with a focus on subcision","volume":"10","author":"Friedmann","year":"2017","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2026072705365544300_ojag137-B5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1080\/14764170410003057","article-title":"Cellulite: a review of its physiology and treatment","volume":"6","author":"Avram","year":"2004","journal-title":"J Cosmet Laser Ther"},{"key":"2026072705365544300_ojag137-B6","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jaad.2009.10.042","article-title":"Treatment of cellulite: part I. 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