{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:11:41Z","timestamp":1785514301218,"version":"3.56.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":194,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020430","name":"LG Chem","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020430","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hyaluronic acid (HA) fillers typically require frequent reinjections. Next-generation fillers, like the Y-phasic YVOIRE\u00ae Y-solution (YYS) 720, require extended clinical validation to confirm their long-term performance and safety. This study evaluated 18-month clinical outcomes, safety, and satisfaction of YYS 720 for nasal and chin augmentation. In this prospective, single-arm study, 16 Korean patients received YYS 720 for the nose (n = 12) and chin (n = 7). Efficacy was evaluated through practitioner-assessed Global Aesthetic Improvement Scale (GAIS), patient-reported FACE-Q\u2122 questionnaires, and objective 3-dimensional morphometric analysis. Safety was monitored through adverse event reporting and visual analog scale (VAS) pain scores. The GAIS responder rate was 100% through Month 12 and 84.21% at Month 18. FACE-Q scores significantly increased until Month 18 for the nose (80.67 \u00b1 24.35, P = .0015) and Month 6 for the chin (86.00 \u00b1 18.43, P = .0156). Three-dimensional analysis showed significant long-term improvements, with 1.73 \u00b1 1.11\u2005mL chin volume at Month 18 (P = .0061) and a 3.99 \u00b1 2.81\u00b0 nasofrontal angle increase at Month 12 (P = .0015) compared with baseline. The mean VAS score was low (1.69 \u00b1 1.40). Only transient swelling and tenderness occurred in 4 patients, with no long-term delayed or serious adverse events. This pilot study provides preliminary evidence supporting the 18-month efficacy and safety of YYS 720. Given its pilot nature, these findings do not constitute claims of long-term reliability or durability, which were not formally assessed.<\/jats:p>\n                  <jats:p>Level of Evidence: 4 (Therapeutic)<\/jats:p>\n                  <jats:p\/>","DOI":"10.1093\/asjof\/ojag146","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:27:49Z","timestamp":1783942069000},"source":"Crossref","is-referenced-by-count":0,"title":["An 18-Month Prospective Evaluation of a Novel Hyaluronic Acid Filler (YYS 720) for 3-Dimensional Nasal and Chin Augmentation"],"prefix":"10.1093","volume":"8","author":[{"given":"Minjeong","family":"Son","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"2026073111464531600_ojag146-B1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1055\/s-0036-1597685","article-title":"Hyaluronic acid fillers in soft tissue regeneration","volume":"33","author":"Fallacara","year":"2017","journal-title":"Facial Plast Surg"},{"key":"2026073111464531600_ojag146-B2","author":"International Society of Aesthetic Plastic Surgery. ISAPS international survey on aesthetic\/cosmetic procedures in 2024"},{"key":"2026073111464531600_ojag146-B3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13005-016-0124-y","article-title":"MRI in detecting facial cosmetic injectable fillers","volume":"12","author":"Tal","year":"2016","journal-title":"Head Face Med"},{"key":"2026073111464531600_ojag146-B4","doi-asserted-by":"publisher","first-page":"e5934","DOI":"10.1097\/gox.0000000000005934","article-title":"Hyaluronic acid filler longevity in the mid-face: a review of 33 magnetic resonance imaging studies","volume":"12","author":"Master","year":"2024","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"2026073111464531600_ojag146-B5","doi-asserted-by":"publisher","first-page":"e38286","DOI":"10.7759\/cureus.38286","article-title":"Adverse events reported from hyaluronic acid dermal filler injections to the facial region: a systematic review and 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