{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:47:33Z","timestamp":1791917253176,"version":"4.3.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":244,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Matex Lab Switzerland SA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fractional nonablative lasers enable controlled dermal heating while preserving epidermal integrity. The 1470\u2005nm wavelength shows strong water absorption and moderate penetration, but in vivo human histological data on early tissue responses remain limited. The aim of this report was to characterize early, time-dependent histological responses and assess short-term histologic tolerability of a fractional 1470\u2005nm laser (LaserMe). Eighteen healthy adults were enrolled and allocated to 6 treatment groups according to energy setting and spot spacing. For the present analysis, only samples treated at 28 and 50\u2005mJ\/point were included, because the 5\u2005mJ\/point setting produced no measurable histological response. Clinical assessment and full-thickness skin biopsies were performed at baseline, immediately after treatment, and on Days 3 and 10. Histology was evaluated using hematoxylin\u2013eosin and Masson's trichrome staining. Treatment produced spatially confined micro-injury zones with the preservation of surrounding tissue. Immediately posttreatment, localized changes were observed at the dermal\u2013epidermal junction with minimal epidermal involvement. By Day 3, re-epithelialization and basement membrane restoration were evident. By Day 10, epidermal continuity was fully restored, with reduced dermal thermal alteration and mild inflammatory infiltrates consistent with reparative processes. Higher energy increased dermal penetration without extending superficial epidermal damage. Fractional 1470\u2005nm laser exposure induces a predictable, localized histological response consistent with possible early tissue remodeling and suggests favorable short-term histologic tolerability in healthy adult skin. This exploratory preliminary report provides mechanistic insight into nonablative laser\u2013tissue interactions and was not designed to assess clinical efficacy or long-term safety.<\/jats:p>\n                  <jats:p>Level of Evidence: 4 (Therapeutic)<\/jats:p>","DOI":"10.1093\/asjof\/ojag161","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:02:08Z","timestamp":1788307328000},"source":"Crossref","is-referenced-by-count":0,"title":["Temporal Histological Tissue Responses Following Fractional Nonablative 1470 nm Laser Exposure: A Pilot In Vivo Human Study"],"prefix":"10.1093","volume":"8","author":[{"given":"Pawe\u0142","family":"Kubik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Gruszczy\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Paw\u0142owska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Malinowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Luiza","family":"Piesiak\u00f3w","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-4837","authenticated-orcid":false,"given":"Brygida","family":"Baran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Paw\u0142owska-Kubik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Kod\u0142uba\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Grzanka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Antosik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart\u0142omiej","family":"\u0141ukasik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"2026101314172383300_ojag161-B1","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1126\/science.6836297","article-title":"Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation","volume":"220","author":"Anderson","year":"1983","journal-title":"Science"},{"key":"2026101314172383300_ojag161-B2","first-page":"477","article-title":"Lasers in dermatology: a review","volume":"67","author":"Massey","year":"2001","journal-title":"Cutis"},{"key":"2026101314172383300_ojag161-B3","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jaad.2008.01.003","article-title":"The spectrum of laser skin resurfacing: nonablative, fractional, and ablative laser resurfacing","volume":"58","author":"Alexiades-Armenakas","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"2026101314172383300_ojag161-B4","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/lsm.20048","article-title":"Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury","volume":"34","author":"Manstein","year":"2004","journal-title":"Lasers Surg Med"},{"key":"2026101314172383300_ojag161-B5","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1111\/j.1524-4725.2005.31934","article-title":"Short-term side effects of fractional photothermolysis","volume":"31","author":"Fisher","year":"2005","journal-title":"Dermatol Surg"},{"key":"2026101314172383300_ojag161-B6","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.clindermatol.2007.05.007","article-title":"Fractional resurfacing","volume":"25","author":"Tannous","year":"2007","journal-title":"Clin Dermatol"},{"key":"2026101314172383300_ojag161-B7","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/s0190-9622(00)90016-1","article-title":"Comparison of carbon dioxide laser, erbium:YAG laser, dermabrasion, and dermatome: a study of thermal damage, wound contraction, and wound healing in a live pig model: implications for skin resurfacing","volume":"42","author":"Ross","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"2026101314172383300_ojag161-B8","doi-asserted-by":"publisher","first-page":"R37","DOI":"10.1088\/0031-9155\/58\/11\/R37","article-title":"Optical properties of biological tissues: a review","volume":"58","author":"Jacques","year":"2013","journal-title":"Phys Med Biol"},{"key":"2026101314172383300_ojag161-B9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2147\/CCID.S69106","article-title":"The role of lasers and intense pulsed light technology in dermatology","volume":"9","author":"Husain","year":"2016","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2026101314172383300_ojag161-B10","doi-asserted-by":"publisher","first-page":"543","DOI":"10.2147\/CCID.S510208","article-title":"Effectiveness and safety of the use of 1470 nm laser therapy in patients suffering from acne scarring of the facial skin","volume":"18","author":"Kubik","year":"2025","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2026101314172383300_ojag161-B11","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3390\/cosmetics12040148","article-title":"The effectiveness and safety of 1470 nm non-ablative laser therapy for the treatment of striae distensae: a pilot study","volume":"12","author":"Kubik","year":"2025","journal-title":"Cosmetics"},{"key":"2026101314172383300_ojag161-B12","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.25107\/2638-4558.1683","article-title":"Assessment of safety and mechanisms of action of the 1470 nm LaserMe device","volume":"8","author":"Kubik","year":"2024","journal-title":"Clin Case Rep Int"},{"key":"2026101314172383300_ojag161-B13","doi-asserted-by":"publisher","first-page":"66","DOI":"10.51670\/aos.v6i3.286","article-title":"Seguran\u00e7a e efetividade da utiliza\u00e7\u00e3o de laser fracionado n\u00e3o ablativo de 1470 nm em paciente de fototipo v\u2014relato de caso","volume":"6","author":"dos Santos","year":"2025","journal-title":"Aesthetic Orofac Sci"},{"key":"2026101314172383300_ojag161-B14","doi-asserted-by":"publisher","first-page":"5097","DOI":"10.1007\/s00266-024-04082-2","article-title":"The endo-lift laser (intralesional 1470 nm diode laser) for dermatological aesthetic conditions: a systematic review","volume":"48","author":"Nilforoushzadeh","year":"2024","journal-title":"Aesthetic Plast Surg"},{"key":"2026101314172383300_ojag161-B15","doi-asserted-by":"publisher","first-page":"448","DOI":"10.5021\/ad.2011.23.4.448","article-title":"Skin characteristics after fractional photothermolysis","volume":"23","author":"Oh","year":"2011","journal-title":"Ann Dermatol"},{"key":"2026101314172383300_ojag161-B16"},{"key":"2026101314172383300_ojag161-B17","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/lsm.20468","article-title":"In vivo histological evaluation of a novel ablative fractional resurfacing device","volume":"39","author":"Hantash","year":"2007","journal-title":"Lasers Surg Med"},{"key":"2026101314172383300_ojag161-B18","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/lsm.23842","article-title":"In vivo histological study evaluating non-ablative fractional 1940-nm laser","volume":"57","author":"Schallen","year":"2025","journal-title":"Lasers Surg Med"},{"key":"2026101314172383300_ojag161-B19","first-page":"99","article-title":"Mechanisms of laser-tissue interaction: II. Tissue thermal properties","volume":"4","author":"Ansari","year":"2013","journal-title":"J Lasers Med Sci"},{"key":"2026101314172383300_ojag161-B20","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4081\/ltj.2025.422","article-title":"In vivo pilot study of the effects of a subdermal 1470 nm diode laser on human skin","volume":"32","author":"Bollero","year":"2025","journal-title":"Laser Ther"},{"key":"2026101314172383300_ojag161-B21","doi-asserted-by":"crossref","DOI":"10.1007\/978-90-481-8831-4","volume-title":"Optical-Thermal Response of Laser-Irradiated Tissue","author":"Welch","year":"2011"}],"container-title":["Aesthetic Surgery Journal Open Forum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/asjopenforum\/advance-article-pdf\/doi\/10.1093\/asjof\/ojag161\/70896063\/ojag161.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asjopenforum\/article-pdf\/doi\/10.1093\/asjof\/ojag161\/70896063\/ojag161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asjopenforum\/article-pdf\/doi\/10.1093\/asjof\/ojag161\/70896063\/ojag161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:17:30Z","timestamp":1791915450000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/asjopenforum\/article\/doi\/10.1093\/asjof\/ojag161\/8778762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":21,"URL":"https:\/\/doi.org\/10.1093\/asjof\/ojag161","relation":{},"ISSN":["2631-4797"],"issn-type":[{"value":"2631-4797","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"ojag161"}}