{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:53:10Z","timestamp":1783075990667,"version":"3.54.6"},"reference-count":33,"publisher":"Informa UK Limited","issue":"2","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,18]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>This study aimed to investigate the roles of COP9 signalosome subunit 8 (COPS8) and its underlying mechanism in cutaneous melanoma. Bioinformatics tools were utilized to analyze the expression of COPS8 in cutaneous melanoma, while Kaplan\u2013Meier analysis was employed to assess the correlation between COPS8 and patients\u2019 overall survival. The proliferation, migration, and invasion of cells were estimated by CCK8, colony formation, and Transwell assays. Western blot was used to check the expression of epithelial\u2013mesenchymal transition (EMT)-related proteins. Results showed that COPS8 was up-regulated and predicted a poor clinical outcome for cutaneous melanoma patients. Knockdown of COPS8 inhibited cutaneous melanoma cell proliferation, migration and invasion, whereas overexpression of COPS8 resulted in the opposite outcomes. The up-regulation of E-cadherin and down-regulation of N-cadherin, vimentin, and snail were caused by silencing COPS8 while their expression showed contrary trends in cells with overexpressed COPS8. Collectively, COPS8 is up-regulated and promotes cutaneous melanoma progression via regulating EMT.<\/jats:p>","DOI":"10.1093\/bbb\/zbaa017","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T01:49:40Z","timestamp":1613872180000},"page":"242-250","source":"Crossref","is-referenced-by-count":3,"title":["COPS8 in cutaneous melanoma: an oncogene that accelerates the malignant development of tumor cells and predicts poor prognosis"],"prefix":"10.1080","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2009-5134","authenticated-orcid":false,"given":"Liangliang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Dermatology, Daqing Oilfield General Hospital, No. 9 ZhongKang street, Daqing City, Heilongjiang Province, P. R. 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