{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:25:53Z","timestamp":1790673953171,"version":"4.1.0"},"reference-count":66,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Phosphonates are organophosphorus compounds possessing a characteristic C\u2212P bond in which phosphorus is directly bonded to carbon. As phosphonates mimic the phosphates and carboxylates of biological molecules to potentially inhibit metabolic enzymes, they could be lead compounds for the development of a variety of drugs. Fosfomycin (FM) is a representative phosphonate natural product that is widely used as an antibacterial drug. Here, we review the biosynthesis of FM, which includes a recent breakthrough to find a missing link in the biosynthetic pathway that had been a mystery for a quarter-century. In addition, we describe the genome mining of phosphonate natural products using the biosynthetic gene encoding an enzyme that catalyzes C\u2013P bond formation. We also introduce the chemoenzymatic synthesis of phosphonate derivatives. These studies expand the repertoires of phosphonates and the related biosynthetic machinery. This review mainly covers the years 2012-2020.<\/jats:p>","DOI":"10.1093\/bbb\/zbaa052","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T14:38:00Z","timestamp":1610548680000},"page":"42-52","source":"Crossref","is-referenced-by-count":21,"title":["Biosynthetic pathways and enzymes involved in the production of phosphonic acid natural products"],"prefix":"10.1080","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-8029","authenticated-orcid":false,"given":"Taro","family":"Shiraishi","sequence":"first","affiliation":[{"name":"Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7221-5858","authenticated-orcid":false,"given":"Tomohisa","family":"Kuzuyama","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan"},{"name":"Collaborative Research Institute for Innovative Microbiology (CRIIM), The University of Tokyo, Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"2021032312373576600_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.abb.2013.12.004","article-title":"Initial characterization of Fom3 from Streptomyces wedmorensis: the methyltransferase in fosfomycin biosynthesis","volume":"543","author":"Allen","year":"2014","journal-title":"Arch Biochem Biophys"},{"key":"2021032312373576600_bib2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1128\/AAC.22.4.571","article-title":"Antibacterial activity and mechanism of action of phosphonopeptides based on aminomethylphosphonic acid","volume":"22","author":"Atherton","year":"1982","journal-title":"Antimicrob Agents 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