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Pinitol has been reported to possess antioxidant potential. The aim was to evaluate the efficacy of pinitol against pressure overload\u2013induced cardiac hypertrophy and fibrosis in the aortic stenosis (AS) rat model. Cardiac hypertrophy was produced in Sprague-Dawley rats by abdominal aortic constriction and treated with lisinopril (15 mg\/kg) or pinitol (5, 10, and 20 mg\/kg). Pressure overload\u2013induced alterations in hemodynamic and left ventricular function tests, cardiac SOD, GSH, MDA, NO, Na-K-ATPase, and mitochondrial complex enzyme levels were significantly attenuated by pinitol. The upregulated mRNA expressions of cardiac ANP, BNP, cTn-I, TNF-\u03b1, IL-1\u03b2, IL-6, Bax, Caspase-3, collagen-I, and cardiac apoptosis were markedly downregulated by pinitol. In conclusion, pinitol ameliorated pressure overload\u2013induced LVH and fibrosis via its anti-inflammatory, antioxidant, antifibrotic, and antiapoptotic potential in experimental AS.<\/jats:p>","DOI":"10.1093\/bbb\/zbaa054","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T01:05:24Z","timestamp":1612573524000},"page":"643-655","source":"Crossref","is-referenced-by-count":6,"title":["Elucidation of the mechanism of action of pinitol against pressure overload\u2013induced cardiac hypertrophy and fibrosis in an animal model of aortic stenosis"],"prefix":"10.1080","volume":"85","author":[{"given":"Xiaojing","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Ninth Hospital of Xi'an, Beilin District, Xi'an City, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, 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