{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:11:14Z","timestamp":1790251874118,"version":"4.1.0"},"reference-count":39,"publisher":"Informa UK Limited","issue":"2","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,18]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Neohesperidin (NEO) exerts antiviral, antioxidant, anti-inflammation, and antitumor effects in some diseases. The purpose of this study was to investigate the effect and mechanism of NEO on myocardial ischemia-reperfusion (I\/R) injury. Results indicated that NEO suppressed the levels of serum inflammatory cytokines, myocardial damage markers, and oxidative stress markers, and increased the levels of antioxidant in myocardial I\/R rats. NEO also inhibited cell apoptosis. Besides, NEO also inhibited the phosphorylation of c-Jun N-terminal kinases (JNK) and nuclear factor kappa B (NF-\u03baB) p65. Furthermore, the protective effects of NEO on myocardial tissue damage, inflammatory cytokines, myocardial injury markers, oxidative stress markers, cell apoptosis, spleen, thymus and liver indices, and phagocytic indices were reversed by JNK activator and NF-\u03baB activator, respectively. In conclusion, NEO alleviates myocardial damage, oxidative stress, cell apoptosis, and immunological imbalance in I\/R injury via the inactivation of JNK and NF-\u03baB, making NEO a potential agent for myocardial I\/R therapy.<\/jats:p>","DOI":"10.1093\/bbb\/zbaa064","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T15:54:25Z","timestamp":1611935665000},"page":"251-261","source":"Crossref","is-referenced-by-count":19,"title":["Neohesperidin alleviated pathological damage and immunological imbalance in rat myocardial ischemia-reperfusion injury via inactivation of JNK and NF-\u03baB p65"],"prefix":"10.1080","volume":"85","author":[{"given":"Aihua","family":"Li","sequence":"first","affiliation":[{"name":"Internal Medicine\u2014Cardiovascular Department, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu Province, 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