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BALB\/c mice were sensitized and challenged with ovalbumin (OVA) to construct asthma model. Mice received Rh1 or tiotropium bromide 0.5 h before OVA challenge. Airway morphology and airway remodeling were assessed by HE staining and Masson's trichrome staining, respectively. Th1\/Th2 cytokines in serum or broncho alveolar lavage fluid (BALF) were measured by ELISA kits. Rh1 significantly alleviated the lung resistance and airway resistance, and reduced the number of total inflammation cells, eosinophils, neutrophils, and lymphocytes in BALF of the asthmatic mice. The morphological changes and collagen deposition of airway were also reduced by Rh1 in asthmatic mice. The increase of Eotaxin, IL-4, IL-5, IL-13, and IL-33 and the decrease of IL-12 and IFN-\u03b3 in both BALF and serum of OVA exposed mice were reversed by Rh1. Rh1 attenuates OVA-induced asthma in the mice model by regulating Th1\/Th2 cytokines balance.<\/jats:p>","DOI":"10.1093\/bbb\/zbab099","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T11:41:26Z","timestamp":1622461286000},"page":"1809-1817","source":"Crossref","is-referenced-by-count":33,"title":["Ginsenoside Rh1 attenuates ovalbumin-induced asthma by regulating Th1\/Th2 cytokines balance"],"prefix":"10.1080","volume":"85","author":[{"given":"Qiang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Hangzhou Hospital of Traditional Chinese Medicine, Xihu District, Hangzhou City, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmiao","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Hangzhou Dingqiao Hospital, Jianggan District, Hangzhou City, Zhejiang Province, 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