{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:31:23Z","timestamp":1768462283969,"version":"3.49.0"},"reference-count":48,"publisher":"Informa UK Limited","issue":"9","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Key Subject Research Projects of Guangdong Province","award":["2019-GDXK-0011"],"award-info":[{"award-number":["2019-GDXK-0011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The present study was conducted to evaluate the effect of Forsythiae Fructus aqueous extract (FAE) against cisplatin-induced emesis and to explore the antiemetic mechanism of FAE by focusing on NLRP3 inflammasome activation in a rat pica model. Our results showed that FAE significantly ameliorated cisplatin-induced acute and delayed pica in rats. Moreover, FAE improved the gastrointestinal histopathological injury and reduced the levels of serum ROS, IL-1\u03b2, and IL-18 in cisplatin-treated rats. In addition, the expressions of NLRP3, ASC, caspase-1, and IL-1\u03b2 and the colocalization of the NLRP3 with ASC or caspase-1 in rat gastric antrum and ileum were also suppressed by FAE. Taken together, our findings indicate that FAE has a therapeutic effect against CINV, which may be related to its inhibition of the activation of NLRP3 inflammasome.<\/jats:p>","DOI":"10.1093\/bbb\/zbab126","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T19:07:52Z","timestamp":1625684872000},"page":"2054-2064","source":"Crossref","is-referenced-by-count":12,"title":["Forsythiae Fructus aqueous extract attenuates cisplatin-induced kaolin consumption (pica) by inhibiting NLRP3 inflammasome activation in rats"],"prefix":"10.1080","volume":"85","author":[{"given":"Qi","family":"Meng","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China"},{"name":"School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 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