{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:06:30Z","timestamp":1740135990717,"version":"3.37.3"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Putian University Science and Technology Project","award":["2\u00a0019\u00a0119"],"award-info":[{"award-number":["2\u00a0019\u00a0119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Isofurans (IsoFs) are a series of novel discovered lipid peroxidation products. This study focused on the investigation of the angiogenic property of IsoF. MTT stain assay indicated that 1 \u00b5m IsoF had the most bioactivity in rat brain endothelial cells (RBECs). IsoF significantly promoted cellular proliferation and migration and remarkably decreased staurosporine-induced apoptosis by TUNEL assay in the RBECs. It successfully up-regulated rat aortic vascularization and choroid explant sprouting, extracellular regulated protein kinases (ERK)1\/2, and triggered calcium release. RT-PCR examination indicated that IsoF up-regulated tumor necrosis factor (TNF)\u03b1, angiopoietin-1 receptor (Tie2), and vascular endothelial growth factor (VEGF)-A, but did not interfere with caspase 2 and VEGF-C in the RBECs. IsoF has pro-angiogenic activity. Calcium release and ERK1\/2 phosphorylation may be involved in the signaling of the IsoF-induced up-regulation of TNF\u03b1, Tie2, and VEGF-A, which could be the molecular mechanism of the pro-angiogenic activity of the IsoF.<\/jats:p>","DOI":"10.1093\/bbb\/zbac146","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T15:38:54Z","timestamp":1662478734000},"page":"1506-1514","source":"Crossref","is-referenced-by-count":0,"title":["Pro-angiogenic activity of isofuran"],"prefix":"10.1093","volume":"86","author":[{"given":"Jingxia","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Translational Tumor Medicine in Fujian Province, School of Basic Medical Science Putian University , Putian, Fujian , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangjiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Translational Tumor Medicine in Fujian Province, School of Basic Medical 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