{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:23:18Z","timestamp":1788618198137,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","award":["F22YY8109033"],"award-info":[{"award-number":["F22YY8109033"]}],"id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,23]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>To investigate the effects of agar oligosaccharides (AO) on lipid metabolism, changes in obesity phenotypes and related molecular factors were evaluated in C57BL\/6N mice fed a high-fat diet (HFD). When HFD-induced obese mice were fed AO, they lost weight. Also, fat accumulation in abdominal and liver tissues was lower in the AO groups than in the Vehicle group. Lipid droplet sizes in tissue sections were reduced by AO, and these observations were mirrored by serum lipid contents. To evaluate the effects of AO on lipid metabolism, lipogenesis and lipolysis-related factors were analyzed. The mRNA expressions of genes involved in lipogenesis, such as adipocyte-protein 2 (aP2) and fatty acid synthase (FAS), were reduced by AO administration, and the expressions of lipolysis-associated proteins, including perilipin, hormone-sensitive lipase (HSL), and fat triglyceride lipase (ATGL), were increased. Taken together, our results suggest that AO should be considered a valuable natural agent that inhibits obesity.<\/jats:p>","DOI":"10.1093\/bbb\/zbac159","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T16:37:53Z","timestamp":1664296673000},"page":"1648-1657","source":"Crossref","is-referenced-by-count":9,"title":["Anti-obesity effects of agar (<i>Gelidium amansii<\/i>)-derived oligosaccharides in high-fat diet-treated C57BL\/6N mice due to differential regulations of lipogenesis and lipolysis"],"prefix":"10.1093","volume":"86","author":[{"given":"Mi Rim","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science\/Life and Industry Convergence Research Institute, Pusan National University , Miryang , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science\/Life and Industry Convergence Research Institute, Pusan National University , Miryang , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Jeong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science\/Life and Industry Convergence Research Institute, Pusan National University , Miryang , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jeong","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science\/Life and Industry Convergence Research Institute, Pusan National University , Miryang , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayun","family":"Seol","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science\/Life and Industry Convergence Research Institute, Pusan National University , Miryang , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science\/Life and Industry Convergence Research Institute, Pusan National University , Miryang , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Wook","family":"Jung","sequence":"additional","affiliation":[{"name":"Miryang Agar-Agar CO. 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