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The control group received distilled water orally and the model and experimental groups I, II, and III received 0, 80, 160, and 320\u00a0mg\/kg HEP respectively for a fortnight after re-molding with cyoclphosphnalide (CTX). Compared with the control group, the secretion of IL-2, IL-4, and IFN-\u03b3, the activity or content of T-AOC, T-SOD, and GSH-PX, and the expression of PCNA mRNA in the thymus and spleen were reduced in immunosuppressed mice (P\u00a0&amp;lt;\u00a0.05 or P\u00a0&amp;lt;\u00a0.01). Compared with immunosuppressed mice, the levels of IL-2, IFN-\u03b3, and GSH-PX and the PCNA mRNA expression of spleen and thymus were increased (P\u00a0&amp;lt;\u00a0.05 or P\u00a0&amp;lt;\u00a0.01), and the microstructure were also obviously improved in the experimental group III. Overall, 320\u00a0mg\/kg of HEP significantly improved the immune and antioxidant functions.<\/jats:p>","DOI":"10.1093\/bbb\/zbac198","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T02:48:18Z","timestamp":1670640498000},"page":"279-289","source":"Crossref","is-referenced-by-count":16,"title":["<i>Hericium erinaceus<\/i>polysaccharide improves the microstructure, immune function, proliferation and reduces apoptosis of thymus and spleen tissue cells of immunosuppressed mice"],"prefix":"10.1093","volume":"87","author":[{"given":"Yujiao","family":"Han","sequence":"first","affiliation":[{"name":"College of Animal Science, Anhui Science and Technology University , Chuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialiang","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Animal Science, Anhui Science and Technology University , Chuzhou, 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