{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:58:46Z","timestamp":1777456726641,"version":"3.51.4"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H05640"],"award-info":[{"award-number":["19H05640"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K22271"],"award-info":[{"award-number":["19K22271"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H02890"],"award-info":[{"award-number":["19H02890"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,24]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>TEAD is a transcription factor responsible for the output of the tumor suppressor Hippo pathway. The transcriptional activity of TEAD requires molecular interaction with its transcriptional coactivator, YAP. Aberrant activation of TEAD is deeply involved in tumorigenesis and is associated with poor prognosis, suggesting that inhibitors targeting the YAP\u2013TEAD system are promising as antitumor agents. In this study, we identified NPD689, an analog of the natural product alkaloid emetine, as an inhibitor of the YAP\u2013TEAD interaction. NPD689 suppressed the transcriptional activity of TEAD and reduced the viability of human malignant pleural mesothelioma and non\u2013small cell lung cancer cells but not the viability of normal human mesothelial cells. Our results suggest that NPD689 is not only a new useful chemical tool for elucidating the biological role of the YAP\u2013TEAD system but also has potential as a starting compound for developing a cancer therapeutic agent that targets the YAP\u2013TEAD interaction.<\/jats:p>","DOI":"10.1093\/bbb\/zbad022","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T23:49:57Z","timestamp":1677023397000},"page":"501-510","source":"Crossref","is-referenced-by-count":3,"title":["Identification of a derivative of the alkaloid emetine as an inhibitor of the YAP\u2013TEAD interaction and its potential as an anticancer agent"],"prefix":"10.1093","volume":"87","author":[{"given":"Saaya","family":"Sekine","sequence":"first","affiliation":[{"name":"Laboratory of Cell Signaling, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences , Hachioji, Tokyo , Japan"},{"name":"Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science , Wako 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