{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:52:33Z","timestamp":1777614753928,"version":"3.51.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100012809","name":"United Graduate School of Agricultural Sciences, Kagoshima University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003983","name":"Iwate University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003983","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>3,6-Epidioxy-1,10-bisaboladiene (EDBD) is an endoperoxide compound isolated from edible wild plants that induces iron-dependent ferroptosis-like cell death in HL-60 cells by decreasing the expression of GPX4 and glutathione. In contrast, sulfasalazine (SSZ), a clinically used anti-inflammatory drug, induces ferroptosis through the system xc\u2212. In this study, we investigated the synergistic effects of these 2 compounds on 3 human breast cancer cell lines (HBC-5, MCF-7, and MDA-MB-231). EDBD-induced cell death was relieved by the lipid peroxidation inhibitor ferrostatin-1 and the iron chelator deferoxamine mesylate (DFOM), indicating that EDBD induced ferroptosis-like cell death. Moreover, cotreatment with EDBD and SSZ synergistically induced cell death in all 3 cell lines. Because the cytotoxicity of the cotreatment was inhibited by DFOM and ferrostatin-1, the combination of EDBD and SSZ synergistically induced ferroptosis. Collectively, EDBD enhanced the effects of SSZ as a clinical anti-inflammatory and anticancer drug candidate.<\/jats:p>","DOI":"10.1093\/bbb\/zbad117","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T02:46:45Z","timestamp":1692672405000},"page":"1336-1344","source":"Crossref","is-referenced-by-count":9,"title":["3,6-Epidioxy-1,10-bisaboladiene and sulfasalazine synergistically induce ferroptosis-like cell death in human breast cancer cell lines"],"prefix":"10.1093","volume":"87","author":[{"given":"Narandulam","family":"Usukhbayar","sequence":"first","affiliation":[{"name":"The United Graduate School of Agricultural Sciences, Iwate University , Morioka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6470-7804","authenticated-orcid":false,"given":"Shota","family":"Uesugi","sequence":"additional","affiliation":[{"name":"Department of Bioresource Sciences, Iwate Biotechnology Research Center , 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