{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:06:32Z","timestamp":1740135992548,"version":"3.37.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU-TC111A02-0","KMU-TC108A02","105-P032","106-P009","101CM-KMU-01"],"award-info":[{"award-number":["KMU-TC111A02-0","KMU-TC108A02","105-P032","106-P009","101CM-KMU-01"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006578","name":"Chi Mei Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006578","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["109-2314-B-037-118","110-2314-B-037-140","111-2314-B-037-008"],"award-info":[{"award-number":["109-2314-B-037-118","110-2314-B-037-140","111-2314-B-037-008"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Four ethanol fractionated crude extracts (EFCEs [A-D]) purified from the leaves of Cinnamomum macrostemon Hayata were screened for antioxidative effects and mitochondrial function in HaCaT cells. The higher cell viability indicated that EFCE C was mildly toxic. Under the treatment of 50 ng\/mL EFCE C, the hydrogen peroxide (H2O2)-induced cytosolic and mitochondrial reactive oxygen species levels were reduced as well as the H2O2-impaired cell viability, mitochondrial membrane potential (MMP), ATP production, and mitochondrial mass. The conversion of globular mitochondria to tubular mitochondria is coincident with EFCE C-restored mitochondrial function. The mitophagy activator rapamycin showed similar effects to EFCE C in recovering the H2O2-impaired cell viability, MMP, ATP production, mitochondrial mass, and also mitophagic proteins such as PINK1, Parkin, LC3 II, and biogenesis protein PGC-1\u03b1. We thereby propose the application of EFCE C in the prevention of oxidative stress in skin cells.<\/jats:p>","DOI":"10.1093\/bbb\/zbae022","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T19:56:19Z","timestamp":1711482979000},"page":"529-537","source":"Crossref","is-referenced-by-count":0,"title":["The crude extract obtained from <i>Cinnamomum macrostemon<\/i> Hayata regulates oxidative stress and mitophagy in keratinocytes"],"prefix":"10.1093","volume":"88","author":[{"given":"Yung-Shun","family":"Su","sequence":"first","affiliation":[{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University , Kaohsiung , Taiwan"},{"name":"Department of Dermatology, Kaohsiung Medical University Hospital , Kaohsiung , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Jen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Life Science, Fu Jen Catholic University , New Taipei 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