{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:34:43Z","timestamp":1789389283001,"version":"build-2803163510"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100018743","name":"Sankei Science Scholarship Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018743","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A new xenicane diterpene named 4\u03b1-acetoxyisodictyohemiacetal (1) was isolated from the brown alga Dictyota coriacea, along with 11 known diterpenoids. The structure of 1 was established by spectroscopic analyses, and its absolute configuration was determined by comparing the experimental and theoretical electronic circular dichroism spectra. Two dictyodiacetal diastereomers (5 and 6) were isolated, and the full NMR assignments were performed. The anti-inflammatory activities of the isolated compounds were evaluated using the lipopolysaccharide-stimulated mouse macrophage cell line, RAW264. The hemiacetal-containing xenicanes and dictyol-type diterpene inhibited not only the production of nitric oxide but also the expression of inducible nitric oxide synthase, interleukin-6, and cyclooxygenase-2 mRNA in RAW264 cells. This study demonstrated that diterpenes from D. coriacea may be useful as natural anti-inflammatory agents.<\/jats:p>","DOI":"10.1093\/bbb\/zbae163","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:39:51Z","timestamp":1731371991000},"page":"224-231","source":"Crossref","is-referenced-by-count":6,"title":["Anti-inflammatory diterpenoids from the brown alga <i>Dictyota coriacea<\/i>"],"prefix":"10.1093","volume":"89","author":[{"given":"Nozomi","family":"Shiiba","sequence":"first","affiliation":[{"name":"Graduate School of Agriculture, Forestry and Fisheries, Kagoshima University , Kagoshima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momochika","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Graduate School of Agriculture, Forestry and Fisheries, Kagoshima University , Kagoshima ,","place":["Japan"]},{"name":"Faculty of Fisheries, Kagoshima University , Kagoshima ,","place":["Japan"]},{"name":"Department of Chemistry, Graduate School of Science, Osaka Metropolitan University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1983-1854","authenticated-orcid":false,"given":"Hikaru","family":"Endo","sequence":"additional","affiliation":[{"name":"Graduate School of Agriculture, Forestry and Fisheries, Kagoshima University , Kagoshima ,","place":["Japan"]},{"name":"Faculty of Fisheries, Kagoshima University , Kagoshima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Graduate School of Science, Osaka Metropolitan University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Graduate School of Science, Osaka Metropolitan University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Graduate School of Science, Osaka Metropolitan University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"2025012412055910400_bib1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ejmech.2010.10.033","article-title":"Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma","volume":"46","author":"Ayyad","year":"2011","journal-title":"Eur J Med Chem"},{"key":"2025012412055910400_bib2","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1007\/s10811-020-02121-4","article-title":"Concise review of the genus Dictyota J.V. 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