{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T17:15:16Z","timestamp":1784394916182,"version":"3.55.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["21K17672"],"award-info":[{"award-number":["21K17672"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012012","name":"Kanamori Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017103","name":"Urakami Foundation for Food and Food Culture Promotion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Carnosic acid is a naturally occurring, plant-derived polyphenolic abietane diterpene with antitumor properties. However, its underlying mechanisms are still unclear. Therefore, we investigated the effects of carnosic acid on lung metastasis in a murine melanoma model. C57BL\/6 mice were intravenously injected with B16-BL6 cells, followed by carnosic acid treatment. Lung weights were recorded, and tumor cell colonies were counted at the end of the experiment. Integrin expression was evaluated using flow cytometry and cell adhesion assays. Lung weights were significantly lower in the carnosic acid group than in the control group, indicating the suppression of metastasis. Carnosic acid suppressed \u03b14 integrin expression in B16-BL6 cells and inhibited \u03b14 and \u03b19 integrin-dependent cell adhesion. Thus, our data suggest that carnosic acid prevents lung metastasis, possibly by suppressing integrin expression. Our findings support the clinical application of carnosic acid as a potential natural antitumor agent, offering a complementary approach to conventional therapies.<\/jats:p>","DOI":"10.1093\/bbb\/zbae177","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:30:21Z","timestamp":1732321821000},"page":"284-293","source":"Crossref","is-referenced-by-count":3,"title":["Carnosic acid inhibits integrin expression and prevents pulmonary metastasis of melanoma"],"prefix":"10.1093","volume":"89","author":[{"given":"Sachi","family":"Shibata","sequence":"first","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University , Soja, Okayama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology, Faculty of Pharmaceutical Sciences, Fukuyama University , Fukuyama, Hiroshima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Kon","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology, Faculty of Pharmaceutical Sciences, Fukuyama University , Fukuyama, Hiroshima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"2025012412061090300_bib1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3390\/ijms18010189","article-title":"Integrins and cell metabolism: an intimate relationship impacting cancer","volume":"18","author":"Ata","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2025012412061090300_bib2","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.3892\/or.2012.1630","article-title":"Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells","volume":"27","author":"Barni","year":"2012","journal-title":"Oncol Rep"},{"key":"2025012412061090300_bib3","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.foodchem.2010.06.056","article-title":"Analysis of the anti-inflammatory properties of Rosmarinus officinalis L. in mice","volume":"124","author":"Beninc\u00e1","year":"2011","journal-title":"Food Chem"},{"key":"2025012412061090300_bib4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.phytochem.2014.12.026","article-title":"Carnosic acid","volume":"115","author":"Birti\u0107","year":"2015","journal-title":"Phytochemistry"},{"key":"2025012412061090300_bib5","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.7512751","article-title":"Requirement of vascular integrin \u03b1v\u03b23 for angiogenesis","volume":"264","author":"Brooks","year":"1994","journal-title":"Science"},{"key":"2025012412061090300_bib6","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/1097-0215(20000815)87:4%3c595::AID-IJC21%3e3.0.CO;2-5","article-title":"Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential","volume":"87","author":"Caltagirone","year":"2000","journal-title":"Int J Cancer"},{"key":"2025012412061090300_bib7","doi-asserted-by":"publisher","first-page":"5520","DOI":"10.1158\/1078-0432.CCR-11-2904","article-title":"Molecular pathways: VCAM-1 as a potential therapeutic target in metastasis","volume":"18","author":"Chen","year":"2012","journal-title":"Clin Cancer Res"},{"key":"2025012412061090300_bib8","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.ccell.2019.01.007","article-title":"Integrin signaling in cancer: mechanotransduction, stemness, epithelial plasticity, and therapeutic resistance","volume":"35","author":"Cooper","year":"2019","journal-title":"Cancer Cell"},{"key":"2025012412061090300_bib9","doi-asserted-by":"publisher","first-page":"102867","DOI":"10.1016\/j.jbc.2022.102867","article-title":"Carnosic acid inhibits secretion of allergic inflammatory mediators in IgE-activated mast cells via direct regulation of Syk activation","volume":"299","author":"Crozier","year":"2023","journal-title":"J Biol Chem"},{"key":"2025012412061090300_bib10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jcp.1137","article-title":"Fibronectin, integrins, and growth control","volume":"189","author":"Danen","year":"2001","journal-title":"J Cell Physiol"},{"key":"2025012412061090300_bib11","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3390\/biomedicines11030829","article-title":"Carnosic acid ameliorates indomethacin-induced gastric ulceration in rats by alleviating oxidative stress and inflammation","volume":"11","author":"Danisman","year":"2023","journal-title":"Biomedicines"},{"key":"2025012412061090300_bib12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrc2748","article-title":"Integrins in cancer: biological implications and therapeutic opportunities","volume":"10","author":"Desgrosellier","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"2025012412061090300_bib13","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s10585-021-10136-5","article-title":"Molecular and cellular mechanisms controlling integrin-mediated cell adhesion and tumor progression in ovarian cancer metastasis: a review","volume":"39","author":"Dhaliwal","year":"2022","journal-title":"Clin Exp Metastasis"},{"key":"2025012412061090300_bib14","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1172\/JCI6869","article-title":"The role of \u03b1v integrins during angiogenesis: insights into potential mechanisms of action and clinical development","volume":"103","author":"Eliceiri","year":"1999","journal-title":"J Clin Invest"},{"key":"2025012412061090300_bib15","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1073\/pnas.98.4.1853","article-title":"Integrin activation controls metastasis in human breast cancer","volume":"98","author":"Felding-Habermann","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025012412061090300_bib16","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1001\/jamaoncol.2015.0735","article-title":"Global burden of disease cancer collaboration: the global burden of cancer 2013","volume":"1","author":"Fitzmaurice","year":"2015","journal-title":"JAMA Oncol"},{"key":"2025012412061090300_bib17","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/0278-6915(95)00077-1","article-title":"Review of the biology of quercetin and related bioflavonoids","volume":"33","author":"Formica","year":"1995","journal-title":"Food Chem Toxicol"},{"key":"2025012412061090300_bib18","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1172\/JCI23445","article-title":"Integrin \u03b14\u03b21-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation","volume":"115","author":"Garmy-Susini","year":"2005","journal-title":"J Clin Invest"},{"key":"2025012412061090300_bib19","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1038\/jid.2011.239","article-title":"SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen I","volume":"131","author":"Girotti","year":"2011","journal-title":"J Innvest Dermatol"},{"key":"2025012412061090300_bib20","first-page":"587","article-title":"The selection and characterization of an invasive variant of the B16 melanoma","volume":"97","author":"Hart","year":"1979","journal-title":"Am J Pathol"},{"key":"2025012412061090300_bib21","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1097\/00002341-199712000-00001","article-title":"The role of the integrin family of adhesion molecules in the development of tumors metastatic to the orbit","volume":"13","author":"Hartstein","year":"1997","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"2025012412061090300_bib22","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.1002\/ijc.25930","article-title":"Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin \u03b1v\u03b23","volume":"129","author":"Hsieh","year":"2011","journal-title":"Int J Cancer"},{"key":"2025012412061090300_bib23","doi-asserted-by":"publisher","first-page":"3849","DOI":"10.1039\/D2FO03904D","article-title":"Carnosic acid protects against doxorubicin-induced cardiotoxicity through enhancing the Nrf2\/HO-1 pathway","volume":"14","author":"Hu","year":"2023","journal-title":"Food Funct"},{"key":"2025012412061090300_bib24","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13046-018-0763-x","article-title":"Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma","volume":"37","author":"Huang","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"2025012412061090300_bib25","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/9780470514719.ch13","article-title":"Mechanisms of VCAM-1 and fibronectin binding to integrin alpha 4 beta 1: implications for integrin function and rational drug design","volume":"189","author":"Humphries","year":"1995","journal-title":"Ciba Found Symp"},{"key":"2025012412061090300_bib26","doi-asserted-by":"publisher","first-page":"8015","DOI":"10.4049\/jimmunol.0900725","article-title":"\u03b19 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis","volume":"182","author":"Kanayama","year":"2009","journal-title":"J Immunol"},{"key":"2025012412061090300_bib27","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/(SICI)1097-4644(199607)62:1%3c123::AID-JCB13%3e3.0.CO;2-O","article-title":"Non-RGD domains of osteopontin promote cell adhesion without involving alpha v integrins","volume":"62","author":"Katagiri","year":"1996","journal-title":"J Cell Biochem"},{"key":"2025012412061090300_bib28","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1248\/bpb.34.1170","article-title":"Prostaglandin E2 and pain\u2014an update","volume":"34","author":"Kawabata","year":"2011","journal-title":"Biol Pharm Bull"},{"key":"2025012412061090300_bib29","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1271\/bbb.110584","article-title":"Antiangiogenic effect of carnosic acid and carnosol, neuroprotective compounds in rosemary leaves","volume":"76","author":"Kayashima","year":"2012","journal-title":"Biosci Biotechnol Biochem"},{"key":"2025012412061090300_bib30","doi-asserted-by":"publisher","first-page":"16389","DOI":"10.1074\/jbc.M114.553610","article-title":"The novel \u03b14B murine \u03b14 integrin protein splicing variant inhibits \u03b14 protein-dependent cell adhesion","volume":"289","author":"Kouro","year":"2014","journal-title":"J Biol Chem"},{"key":"2025012412061090300_bib31","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S1383-5742(98)00019-2","article-title":"Antimutagenic and anticarcinogenic activity of tea polyphenols","volume":"436","author":"Kuroda","year":"1999","journal-title":"Mutat Res"},{"key":"2025012412061090300_bib32","doi-asserted-by":"publisher","first-page":"815","DOI":"10.3390\/cells8080815","article-title":"Osteopontin as a link between inflammation and cancer: the thorax in the spotlight","volume":"8","author":"Lamort","year":"2019","journal-title":"Cells"},{"key":"2025012412061090300_bib33","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/j.1549-8719.2001.tb00180.x","article-title":"Endothelial expression of vascular cell adhesion molecule-1 correlates with metastatic pattern in spontaneous melanoma","volume":"8","author":"Langley","year":"2001","journal-title":"Microcirculation"},{"key":"2025012412061090300_bib34","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1002\/ptr.7795","article-title":"Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer","volume":"37","author":"Liang","year":"2023","journal-title":"Phytother Res"},{"key":"2025012412061090300_bib35","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/ddr.20265","article-title":"Integrin \u03b1v\u03b23-targeted cancer therapy","volume":"69","author":"Liu","year":"2008","journal-title":"Drug Dev Res"},{"key":"2025012412061090300_bib36","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.mehy.2011.04.002","article-title":"The role of COX-2 and Nrf2\/ARE in anti-inflammation and antioxidative stress: aging and anti-aging","volume":"77","author":"Luo","year":"2011","journal-title":"Med Hypotheses"},{"key":"2025012412061090300_bib37","doi-asserted-by":"publisher","first-page":"4621","DOI":"10.1073\/pnas.84.13.4621","article-title":"Tenascin is a stromal marker for epithelial malignancy in the mammary gland","volume":"84","author":"Mackie","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025012412061090300_bib38","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1365-2133.2010.09737.x","article-title":"Psoriasis and extra domain A fibronectin loops","volume":"163","author":"McFadden","year":"2010","journal-title":"Br J Dermatol"},{"key":"2025012412061090300_bib39","doi-asserted-by":"publisher","first-page":"7927","DOI":"10.1158\/0008-5472.CAN-10-0194","article-title":"Survivin enhances motility of melanoma cells by supporting Akt activation and \u03b15 integrin upregulation","volume":"70","author":"McKenzie","year":"2010","journal-title":"Cancer Res"},{"key":"2025012412061090300_bib40","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1038\/s41390-020-01177-9","article-title":"The role of integrins in inflammation and angiogenesis","volume":"89","author":"Mezu-Ndubuisi","year":"2021","journal-title":"Pediatr Res"},{"key":"2025012412061090300_bib41","doi-asserted-by":"publisher","first-page":"731","DOI":"10.3390\/nu8110731","article-title":"Anticancer effects of rosemary (Rosmarinus officinalis L.) extract and rosemary extract polyphenols","volume":"8","author":"Moore","year":"2016","journal-title":"Nutrients"},{"key":"2025012412061090300_bib42","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11010-014-2316-8","article-title":"Anti-tumor properties of cis-resveratrol methylated analogs in metastatic mouse melanoma cells","volume":"402","author":"Morris","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"2025012412061090300_bib43","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1111\/j.1349-7006.1992.tb02765.x","article-title":"Differences in chemotaxis to fibronectin in weakly and highly metastatic tumor cells","volume":"83","author":"Murata","year":"1992","journal-title":"Jpn J Cancer Res"},{"key":"2025012412061090300_bib44","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1016\/j.bmcl.2004.01.091","article-title":"Carnosic acid, a new class of lipid absorption inhibitor from sage","volume":"14","author":"Ninomiya","year":"2004","journal-title":"Bioorg Med Chem Lett"},{"key":"2025012412061090300_bib45","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.3390\/antiox10101591","article-title":"Curcumin and carnosic acid cooperate to inhibit proliferation and alter mitochondrial function of metastatic prostate cancer cells","volume":"10","author":"Ossikbayeva","year":"2021","journal-title":"Antioxidants"},{"key":"2025012412061090300_bib46","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1002\/jcb.23130","article-title":"Endostatin suppresses colorectal tumor-induced lymphangiogenesis by inhibiting expression of fibronectin extra domain A and integrin \u03b19","volume":"112","author":"Ou","year":"2011","journal-title":"J Cell Biochem"},{"key":"2025012412061090300_bib47","doi-asserted-by":"publisher","first-page":"12698","DOI":"10.3390\/ijms150712698","article-title":"Carnosic acid inhibits the epithelial-mesenchymal transition in B16F10 melanoma cells: a possible mechanism for the inhibition of cell migration","volume":"15","author":"Park","year":"2014","journal-title":"Int J Mol Sci"},{"key":"2025012412061090300_bib48","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1593\/neo.91604","article-title":"Constitutive expression of the \u03b14 integrin correlates with tumorigenicity and lymph node metastasis of the B16 murine melanoma","volume":"12","author":"Rebhun","year":"2010","journal-title":"Neoplasia"},{"key":"2025012412061090300_bib49","doi-asserted-by":"publisher","first-page":"32","DOI":"10.2174\/1570163814666170413121732","article-title":"Anti-carcinogenic effects of carnosol\u2014an updated review","volume":"15","author":"Samarghandian","year":"2018","journal-title":"Curr Drug Discov Technol"},{"key":"2025012412061090300_bib50","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1158\/0008-5472.CAN-17-1518","article-title":"Kindlin-1 promotes pulmonary breast cancer metastasis","volume":"78","author":"Sarvi","year":"2018","journal-title":"Cancer Res"},{"key":"2025012412061090300_bib51","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3390\/ijms19010263","article-title":"Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application","volume":"19","author":"Seca","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2025012412061090300_bib52","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1016\/S0002-9440(10)65719-7","article-title":"Role of the \u03b23 integrin subunit in human primary melanoma progression: multifunctional activities associated with \u03b1v\u03b23 integrin expression","volume":"153","author":"Seftor","year":"1998","journal-title":"Am J Pathol"},{"key":"2025012412061090300_bib53","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.lfs.2008.11.018","article-title":"Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7","volume":"84","author":"Sen","year":"2009","journal-title":"Life Sci"},{"key":"2025012412061090300_bib54","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.3892\/ijo.2017.3970","article-title":"Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction","volume":"50","author":"Shi","year":"2017","journal-title":"Int J Oncol"},{"key":"2025012412061090300_bib55","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1080\/09637486.2016.1208734","article-title":"Carnosic acid protects starvation-induced SH-SY5Y cell death through ERK1\/2 and Akt pathways, autophagy, and FoxO3a","volume":"67","author":"Shibata","year":"2016","journal-title":"Int J Food Sci Nutr"},{"key":"2025012412061090300_bib56","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/1743-422X-10-303","article-title":"Antiviral activity of carnosic acid against respiratory syncytial virus","volume":"10","author":"Shin","year":"2013","journal-title":"Virol J"},{"key":"2025012412061090300_bib57","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.3389\/fpls.2016.01667","article-title":"Lead phytochemicals for anticancer drug development","volume":"7","author":"Singh","year":"2016","journal-title":"Front Plant Sci"},{"key":"2025012412061090300_bib58","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/j.1538-7836.2005.01770.x","article-title":"Increased metastatic potential of tumor cells in von Willebrand factor-deficient mice","volume":"4","author":"Terraube","year":"2006","journal-title":"J Thromb Haemost"},{"key":"2025012412061090300_bib59","doi-asserted-by":"publisher","first-page":"10300","DOI":"10.3390\/ijms231810300","article-title":"Histidine-rich glycoprotein suppresses the S100A8\/A9-mediated organotropic metastasis of melanoma cells","volume":"23","author":"Tomonobu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025012412061090300_bib60","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/s41419-021-03771-z","article-title":"Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1\/HIF-1\u03b1 interaction in lung cancer","volume":"12","author":"Ullah","year":"2021","journal-title":"Cell Death Dis"},{"key":"2025012412061090300_bib61","doi-asserted-by":"publisher","first-page":"765","DOI":"10.2174\/1871520622666220831124321","article-title":"Molecular mechanisms of sanguinarine in cancer prevention and treatment","volume":"23","author":"Ullah","year":"2023","journal-title":"Anticancer Agents Med Chem"},{"key":"2025012412061090300_bib62","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1111\/j.0022-202X.2004.23474.x","article-title":"Extra-domain-A fibronectin: a new marker of fibrosis in cutaneous graft-versus-host disease","volume":"123","author":"van\u00a0der\u00a0Straaten","year":"2004","journal-title":"J Invest Dermatol"},{"key":"2025012412061090300_bib63","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/S0955-0674(96)80115-3","article-title":"Integrins and cancer","volume":"8","author":"Varner","year":"1996","journal-title":"Curr Opin Cell Biol"},{"key":"2025012412061090300_bib64","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1002\/ijc.32359","article-title":"Integrin \u03b19 depletion promotes \u03b2-catenin degradation to suppress triple-negative breast cancer tumor growth and metastasis","volume":"145","author":"Wang","year":"2019","journal-title":"Int J Cancer"},{"key":"2025012412061090300_bib65","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.7150\/jca.20480","article-title":"Osteopontin\u2014a promising biomarker for cancer therapy","volume":"8","author":"Wei","year":"2017","journal-title":"J Cancer"},{"key":"2025012412061090300_bib66","doi-asserted-by":"publisher","first-page":"a006478","DOI":"10.1101\/cshperspect.a006478","article-title":"\u03b1V integrins in angiogenesis and cancer","volume":"1","author":"Weis","year":"2011","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2025012412061090300_bib67","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.2174\/1381612828666220501165644","article-title":"ITGA9: potential biomarkers and therapeutic targets in different tumors","volume":"28","author":"Wu","year":"2022"},{"key":"2025012412061090300_bib68","doi-asserted-by":"publisher","first-page":"11036","DOI":"10.1038\/s41598-017-11408-5","article-title":"Carnosic acid prevents dextran sulfate sodium-induced acute colitis associated with the regulation of the Keap1\/Nrf2 pathway","volume":"7","author":"Yang","year":"2017","journal-title":"Sci Rep"},{"key":"2025012412061090300_bib69","doi-asserted-by":"publisher","first-page":"32314","DOI":"10.1074\/jbc.M113.501668","article-title":"How natalizumab binds and antagonizes \u03b14 integrins","volume":"288","author":"Yu","year":"2013","journal-title":"J Biol Chem"},{"key":"2025012412061090300_bib70","doi-asserted-by":"publisher","first-page":"7864","DOI":"10.12659\/MSM.917735","article-title":"Antiproliferative activity of carnosic acid is mediated via inhibition of cell migration and invasion, and suppression of phosphatidylinositol 3-kinases (PI3K)\/AKT\/mammalian target of rapamycin (mTOR) signaling pathway","volume":"25","author":"Zhao","year":"2019","journal-title":"Med Sci Monit"}],"container-title":["Bioscience, Biotechnology, and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bbb\/advance-article-pdf\/doi\/10.1093\/bbb\/zbae177\/60792159\/zbae177.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bbb\/article-pdf\/89\/2\/284\/60792159\/zbae177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bbb\/article-pdf\/89\/2\/284\/60792159\/zbae177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T12:06:19Z","timestamp":1737720379000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bbb\/article\/89\/2\/284\/7907260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,22]]},"references-count":70,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,11,22]]},"published-print":{"date-parts":[[2025,1,24]]}},"URL":"https:\/\/doi.org\/10.1093\/bbb\/zbae177","relation":{},"ISSN":["1347-6947"],"issn-type":[{"value":"1347-6947","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2024,11,22]]}}}