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Mouse splenocytes treated with \u03b3-ray-irradiated SANK70258 produced higher levels of interferon (IFN)-\u03b3 than those with 7 types of lactic acid bacteria. IFN-\u03b3 was mainly produced by natural killer (NK) cells, involving IL-12\/IL-23, dendritic cells (DCs), and NF-\u03baB signaling. SANK70258 induced the release of IL-6, IL-10, and IL-12p40 from mouse DCs and the expression of cytokine genes in the human monocyte. Cytokine release from SANK70258-treated DCs was partially reduced by the knockdown of Tlr2 or Nod2, and was abolished by Myd88 knockout. DC-stimulating components of SANK70258 were enriched in ether- and butanol-insoluble peptidoglycan-related fractions. The SANK70258 component induced high levels of immunoglobulin (Ig) A production in Peyer\u2019s patch cells, and its oral intake significantly increased intestinal IgA and IgA-expressing B cells in Peyer\u2019s patches in mice. We conclude that the SANK70258 component exhibits high activity as an immunostimulant that induces the production of IFN-\u03b3 and IgA.<\/jats:p>","DOI":"10.1093\/bbb\/zbae203","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T07:27:59Z","timestamp":1735284479000},"page":"622-632","source":"Crossref","is-referenced-by-count":1,"title":["Immunostimulatory effects of\n                    <i>Heyndrickxia coagulans<\/i>\n                    SANK70258"],"prefix":"10.1093","volume":"89","author":[{"given":"Yuki","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Biological Science and Technology, Tokyo University of Science , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niya","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, Tokyo University of Science , Tokyo 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