{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T12:40:16Z","timestamp":1740055216528,"version":"3.37.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eumelanin, a type of skin melanin pigment, possesses the ability to absorb a wide range of wavelengths, providing protection to the skin from ultraviolet radiation. However, excessive production of eumelanin may result in hyperpigmentation. Consequently, the development of skin-brightening products that suppress eumelanin synthesis to achieve a lighter and more even skin tone is necessary. The present study investigated the potential application of Melaleuca leucadendron as a natural skin-brightening agent. We investigated the effects of the ethanol leaf extract of M. leucadendron on \u03b1-melanocyte-stimulating hormone-induced melanogenesis in B16F10 cells and identified the key factors involved in melanogenesis. This leaf extract significantly inhibited melanin production by downregulating the expression of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein 1, and dopachrome tautomerase without causing cytotoxicity. Furthermore, it substantially reduced melanin content in a 3D skin model. These results suggest that the extract of M. leucadendron is a promising, safe, and effective skin-brightening agent.<\/jats:p>","DOI":"10.1093\/bbb\/zbae204","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T05:21:10Z","timestamp":1737091270000},"page":"382-389","source":"Crossref","is-referenced-by-count":0,"title":["Regulation of eumelanogenesis-related genes by ethanol extract of <i>Melaleuca leucadendron<\/i> leaves"],"prefix":"10.1093","volume":"89","author":[{"given":"Myungsam","family":"Park","sequence":"first","affiliation":[{"name":"Department of Genetics & Biotechnology, Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University , Youngin ,","place":["Korea"]},{"name":"R&I Center, COSMAX China , Shanghai ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younhwa","family":"Nho","sequence":"additional","affiliation":[{"name":"R&I Unit, COSMAX BTI , Seongnam ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Insanu","family":"Muhamad","sequence":"additional","affiliation":[{"name":"Pharmacy Biology, School of Pharmacy Institut Teknologi Bandung , Bandung ,","place":["Indonesia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizaldy","family":"Defri","sequence":"additional","affiliation":[{"name":"Pharmacy Biology, School of Pharmacy Institut Teknologi Bandung , Bandung ,","place":["Indonesia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Sung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Genetics & Biotechnology, Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University , Youngin ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"2025022012225463400_bib1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5564\/mjas.v21i02.902","article-title":"Anti-cancer effect of plantago depressa ethanolic extract in B16F10 skin cancer cells","volume":"21","author":"Ay","year":"2017","journal-title":"Mongol J Agric Sci"},{"key":"2025022012225463400_bib2","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.freeradbiomed.2020.07.022","article-title":"Melaleuca leucadendron (L.) 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