{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:46:16Z","timestamp":1792097176147,"version":"4.4.0"},"reference-count":121,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Osaka Metropolitan University"},{"name":"Otemae University"},{"DOI":"10.13039\/501100012314","name":"Shinshu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Food-derived polyphenols and some alkaloids have reported bioactivities related to the prevention of systemic metabolic disorders such as obesity, glucose intolerance, and dyslipidemia. For food-derived components to exert their functions in vivo, it is essential to interact with biological factors such as proteins, lipids, and nucleic acids. However, it is still unclear whether bioactive components in foods express functions related to their target factors. In this review, I introduce the target proteins in which food-derived components express functions in cells.<\/jats:p>","DOI":"10.1093\/bbb\/zbaf003","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T02:51:21Z","timestamp":1736823081000},"page":"523-532","source":"Crossref","is-referenced-by-count":1,"title":["Functional expression mechanisms of food-derived components based on target proteins"],"prefix":"10.1093","volume":"89","author":[{"given":"Takakazu","family":"Mitani","sequence":"first","affiliation":[{"name":"Division of Food Science and Biotechnology, Graduated School of Science and Technology, Shinshu University , Nagano ,","place":["Japan"]},{"name":"Department of Agricultural and Life Sciences, Faculty of Agriculture, Shinshu University , Nagano ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"2025032500383245600_bib1","doi-asserted-by":"publisher","first-page":"eabn8017","DOI":"10.1126\/scisignal.abn8017","article-title":"Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis","volume":"15","author":"Abe","year":"2022","journal-title":"Sci Signal"},{"key":"2025032500383245600_bib2","doi-asserted-by":"publisher","first-page":"10500","DOI":"10.1002\/jcp.27719","article-title":"A2a adenosine receptor agonist improves endoplasmic reticulum stress in MIN6 cell line through protein kinase A\/protein kinase B\/cyclic adenosine monophosphate response element-binding protein\/ and growth arrest and DNA-damage-inducible 34\/ eukaryotic initiation factor 2\u03b1 pathways","volume":"234","author":"Arasi","year":"2019","journal-title":"J Cell Physiol"},{"key":"2025032500383245600_bib3","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/mnfr.201500222","article-title":"Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models","volume":"59","author":"Arntz","year":"2015","journal-title":"Mol Nutr Food Res"},{"key":"2025032500383245600_bib4","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.1210\/jc.2006-2295","article-title":"Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study","volume":"92","author":"Atteritano","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2025032500383245600_bib5","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.3945\/jn.114.196436","article-title":"MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers","volume":"144","author":"Baier","year":"2014","journal-title":"J Nutr"},{"key":"2025032500383245600_bib6","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.1096\/fj.15-270579","article-title":"Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting","volume":"29","author":"B\u00e9dard","year":"2015","journal-title":"FASEB J"},{"key":"2025032500383245600_bib7","doi-asserted-by":"publisher","first-page":"2497S","DOI":"10.1093\/jn\/133.7.2497S","article-title":"DING, a genistein target in human breast cancer: a protein without a gene","volume":"133","author":"Belenky","year":"2003","journal-title":"J Nutr"},{"key":"2025032500383245600_bib8","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.nut.2009.04.023","article-title":"Bioactive compounds: definition and assessment of activity","volume":"25","author":"Biesalski","year":"2009","journal-title":"Nutrition"},{"key":"2025032500383245600_bib9","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/onc.2010.501","article-title":"Adenine nucleotide translocase family: four isoforms for apoptosis modulation in cancer","volume":"30","author":"Brenner","year":"2011","journal-title":"Oncogene"},{"key":"2025032500383245600_bib10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1124\/dmd.119.089326","article-title":"Carbonyl reductase 1 plays a significant role in converting doxorubicin to cardiotoxic doxorubicinol in mouse liver, but the majority of the doxorubicinol-forming activity remains unidentified","volume":"48","author":"Breysse","year":"2020","journal-title":"Drug Metab Dispos"},{"key":"2025032500383245600_bib11","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1021\/acschembio.1c00014","article-title":"Systematically studying the effect of small molecules interacting with RNA in cellular and preclinical models","volume":"16","author":"Bush","year":"2021","journal-title":"ACS Chem Biol"},{"key":"2025032500383245600_bib12","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.1021\/acs.jafc.8b07248","article-title":"Role of theobromine in cocoa\u2019s metabolic properties in healthy rats","volume":"67","author":"Camps-Bossacoma","year":"2019","journal-title":"J Agric Food Chem"},{"key":"2025032500383245600_bib13","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.cmet.2015.05.023","article-title":"NAD(+) metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus","volume":"22","author":"Cant\u00f3","year":"2015","journal-title":"Cell Metab"},{"key":"2025032500383245600_bib14","doi-asserted-by":"publisher","first-page":"e139160","DOI":"10.1172\/jci.insight.139160","article-title":"\u03b23-Adrenergic receptors regulate human brown\/beige adipocyte lipolysis and thermogenesis","volume":"6","author":"Cero","year":"2021","journal-title":"JCI Insight"},{"key":"2025032500383245600_bib15","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12986-020-0426-8","article-title":"S-Equol ameliorates insulin secretion failure through Chrebp\/Txnip signaling via modulating PKA\/PP2A activities","volume":"17","author":"Chen","year":"2020","journal-title":"Nutr Metab (Lond)"},{"key":"2025032500383245600_bib16","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/s41422-020-0389-3","article-title":"SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs","volume":"31","author":"Chen","year":"2021","journal-title":"Cell Res"},{"key":"2025032500383245600_bib17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cmet.2018.11.002","article-title":"New advances in adaptive thermogenesis: UCP1 and beyond","volume":"29","author":"Chouchani","year":"2019","journal-title":"Cell Metab"},{"key":"2025032500383245600_bib18","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1002\/jcp.24531","article-title":"Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway","volume":"229","author":"Chowdhury","year":"2014","journal-title":"J Cell Physiol"},{"key":"2025032500383245600_bib19","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1128\/MCB.00852-09","article-title":"Control of adipogenesis by the SUMO-specific protease SENP2","volume":"30","author":"Chung","year":"2010","journal-title":"Mol Cell Biol"},{"key":"2025032500383245600_bib20","doi-asserted-by":"publisher","first-page":"102051","DOI":"10.1016\/j.molmet.2024.102051","article-title":"cAMP driven UCP1 induction in human adipocytes requires ATGL-catalyzed lipolysis","volume":"90","author":"Desai","year":"2024","journal-title":"Mol Metab"},{"key":"2025032500383245600_bib21","doi-asserted-by":"publisher","first-page":"7028","DOI":"10.1007\/s12035-016-0215-6","article-title":"Molecular and therapeutic targets of genistein in Alzheimer\u2019s disease","volume":"54","author":"Devi","year":"2017","journal-title":"Mol Neurobiol"},{"key":"2025032500383245600_bib22","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1046\/j.1463-1326.2001.00158.x","article-title":"Overexpression of the A1 adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance","volume":"3","author":"Dong","year":"2001","journal-title":"Diabetes Obes Metab"},{"key":"2025032500383245600_bib24","doi-asserted-by":"publisher","first-page":"4159","DOI":"10.3390\/nu5104159","article-title":"Health benefits of methylxanthines in cacao and chocolate","volume":"5","author":"Franco","year":"2013","journal-title":"Nutrients"},{"key":"2025032500383245600_bib25","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1007\/s002100000313","article-title":"Structure and function of adenosine receptors and their genes","volume":"362","author":"Fredholm","year":"2000","journal-title":"Naunyn Schmied Arch Pharmacol"},{"key":"2025032500383245600_bib26","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/bs.apcsb.2019.01.001","article-title":"Estrogen receptor signaling mechanisms","volume":"116","author":"Fuentes","year":"2019","journal-title":"Adv Protein Chem Struct Biol"},{"key":"2025032500383245600_bib27","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/dgd.12114","article-title":"Exchange protein activated by cyclic AMP is involved in the regulation of adipogenic genes during 3T3-L1 fibroblasts differentiation","volume":"56","author":"Gabrielli","year":"2014","journal-title":"Dev Growth Differ"},{"key":"2025032500383245600_bib28","doi-asserted-by":"publisher","first-page":"1453164","DOI":"10.3389\/fonc.2024.1453164","article-title":"Resveratrol enhances the antiliver cancer effect of cisplatin by targeting the cell membrane protein PLA2","volume":"14","author":"Gao","year":"2024","journal-title":"Front Oncol"},{"key":"2025032500383245600_bib29","doi-asserted-by":"publisher","first-page":"107178","DOI":"10.1016\/j.isci.2023.107178","article-title":"A2B adenosine receptor activation and modulation by protein kinase C","volume":"26","author":"Gao","year":"2023","journal-title":"iScience"},{"key":"2025032500383245600_bib30","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ijantimicag.2008.06.001","article-title":"80th anniversary of the discovery of penicillin an appreciation of Sir Alexander Fleming","volume":"32","author":"Geddes","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"2025032500383245600_bib31","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.cell.2007.10.004","article-title":"Developmental origin of fat: tracking obesity to its source","volume":"131","author":"Gesta","year":"2007","journal-title":"Cell"},{"key":"2025032500383245600_bib32","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1055\/s-2007-1000624","article-title":"Friedrich Wilhelm Adam Sert\u00fcrner\u2013dem Entdecker des Morphins zum 150. Todestag [Friedrich Wilhelm Adam Sert\u00fcrner\u2212the discoverer of morphine]","volume":"26","author":"Goerig","year":"1991","journal-title":"An\u00e4sthesiol Intensivmed Notfallmed Schmerzther"},{"key":"2025032500383245600_bib33","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1002\/1873-3468.14792","article-title":"Molecular mechanisms of perilipin protein function in lipid droplet metabolism","volume":"598","author":"Griseti","year":"2024","journal-title":"FEBS Lett"},{"key":"2025032500383245600_bib34","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1039\/D1BM01797G","article-title":"Bovine colostrum derived-exosomes prevent dextran sulfate sodium-induced intestinal colitis via suppression of inflammation and oxidative stress","volume":"10","author":"Han","year":"2022","journal-title":"Biomater Sci"},{"key":"2025032500383245600_bib35","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.bbrc.2010.04.135","article-title":"Isolation of bovine milk-derived microvesicles carrying mRNAs and microRNAs","volume":"396","author":"Hata","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"2025032500383245600_bib36","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3177\/jnsv.60.291","article-title":"S-equol enantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic \u03b2-cells","volume":"60","author":"Horiuchi","year":"2014","journal-title":"J Nutr Sci Vitaminol"},{"key":"2025032500383245600_bib37","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.3945\/jn.117.250860","article-title":"S-equol activates cAMP signaling at the plasma membrane of INS-1 pancreatic \u03b2-cells and protects against streptozotocin-induced hyperglycemia by increasing \u03b2-cell function in male mice","volume":"147","author":"Horiuchi","year":"2017","journal-title":"J Nutr"},{"key":"2025032500383245600_bib38","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1093\/bbb\/zbab203","article-title":"Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria","volume":"86","author":"Ikeda","year":"2022","journal-title":"Biosci Biotechnol Biochem"},{"key":"2025032500383245600_bib39","doi-asserted-by":"publisher","first-page":"358","DOI":"10.3177\/jnsv.59.358","article-title":"Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4\u2032-amino-3,5-dihydroxy-trans-stilbene","volume":"59","author":"Ito","year":"2013","journal-title":"J Nutr Sci Vitaminol"},{"key":"2025032500383245600_bib40","doi-asserted-by":"publisher","first-page":"4831","DOI":"10.3168\/jds.2012-5489","article-title":"Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions","volume":"95","author":"Izumi","year":"2012","journal-title":"J Dairy Sci"},{"key":"2025032500383245600_bib41","doi-asserted-by":"publisher","first-page":"2920","DOI":"10.3168\/jds.2014-9076","article-title":"Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages","volume":"98","author":"Izumi","year":"2015","journal-title":"J Dairy Sci"},{"key":"2025032500383245600_bib42","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s12257-018-0434-y","article-title":"Theobromine, a methylxanthine in cocoa bean, stimulates thermogenesis by inducing white fat browning and activating brown adipocytes","volume":"23","author":"Jang","year":"2018","journal-title":"Biotechnol Bioproc E"},{"key":"2025032500383245600_bib43","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1007\/s00394-020-02184-6","article-title":"Theobromine alleviates diet-induced obesity in mice via phosphodiesterase-4 inhibition","volume":"59","author":"Jang","year":"2020","journal-title":"Eur J Nutr"},{"key":"2025032500383245600_bib44","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1039\/C5FO00397K","article-title":"Theobromine inhibits differentiation of 3T3-L1 cells during the early stage of adipogenesis via AMPK and MAPK signaling pathways","volume":"6","author":"Jang","year":"2015","journal-title":"Food Funct."},{"key":"2025032500383245600_bib45","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1152\/physrev.00041.2018","article-title":"Free fatty acid receptors in health and disease","volume":"100","author":"Kimura","year":"2020","journal-title":"Physiol Rev"},{"key":"2025032500383245600_bib46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1758-907X-1-7","article-title":"microRNA as a new immune-regulatory agent in breast milk","volume":"1","author":"Kosaka","year":"2010","journal-title":"Silence"},{"key":"2025032500383245600_bib47","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1111\/j.1349-7006.2008.00903.x","article-title":"CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients","volume":"99","author":"Lal","year":"2008","journal-title":"Cancer Sci"},{"key":"2025032500383245600_bib48","doi-asserted-by":"publisher","first-page":"801","DOI":"10.3945\/ajcn.116.151464","article-title":"A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women","volume":"106","author":"Lambert","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"2025032500383245600_bib49","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/mnfr.200800331","article-title":"Structure-activity relationships of resveratrol and derivatives in breast cancer cells","volume":"53","author":"Lappano","year":"2009","journal-title":"Mol Nutr Food Res"},{"key":"2025032500383245600_bib50","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1080\/10408390701542716","article-title":"The key importance of soy isoflavone bioavailability to understanding health benefits","volume":"48","author":"Larkin","year":"2008","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2025032500383245600_bib51","doi-asserted-by":"publisher","first-page":"14246","DOI":"10.1074\/jbc.M110.147348","article-title":"7,3\u2032,4\u2032-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4","volume":"286","author":"Lee","year":"2011","journal-title":"J Biol Chem"},{"key":"2025032500383245600_bib52","doi-asserted-by":"publisher","first-page":"e00601","DOI":"10.1128\/MCB.00601-18","article-title":"Transcriptional and epigenomic regulation of adipogenesis","volume":"39","author":"Lee","year":"2019","journal-title":"Mol Cell Biol"},{"key":"2025032500383245600_bib53","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.phymed.2018.06.043","article-title":"Synergistic effects of cAMP-dependent protein kinase A and AMP-activated protein kinase on lipolysis in kinsenoside-treated C3H10T1\/2 adipocytes","volume":"55","author":"Lee","year":"2019","journal-title":"Phytomedicine"},{"key":"2025032500383245600_bib54","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1101\/gad.1709008","article-title":"PPARgamma and C\/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale","volume":"22","author":"Lefterova","year":"2008","journal-title":"Genes Dev"},{"key":"2025032500383245600_bib55","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12937-024-00932-6","article-title":"Effect of soy isoflavone supplementation on blood pressure: a meta-analysis of randomized controlled trials","volume":"23","author":"Lei","year":"2024","journal-title":"Nutr J"},{"key":"2025032500383245600_bib56","doi-asserted-by":"publisher","first-page":"e0211431","DOI":"10.1371\/journal.pone.0211431","article-title":"Bovine milk-derived exosomes enhance goblet cell activity and prevent the development of experimental necrotizing enterocolitis","volume":"14","author":"Li","year":"2019","journal-title":"PLoS One"},{"key":"2025032500383245600_bib57","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1089\/cmb.2019.0443","article-title":"Drug-target interaction network analysis of gene-phenotype connectivity maintained by genistein","volume":"27","author":"Li","year":"2020","journal-title":"J Comput Biol"},{"key":"2025032500383245600_bib58","doi-asserted-by":"publisher","first-page":"6285","DOI":"10.1021\/acs.jafc.2c00631","article-title":"Advances in bioactivity of microRNAs of plant-derived exosome-like nanoparticles and milk-derived extracellular vesicles","volume":"70","author":"Li","year":"2022","journal-title":"J Agric Food Chem"},{"key":"2025032500383245600_bib59","doi-asserted-by":"publisher","first-page":"480","DOI":"10.3945\/ajcn.2009.28203","article-title":"Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: a meta-analysis of randomized placebo-controlled trials","volume":"91","author":"Li","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"2025032500383245600_bib60","doi-asserted-by":"publisher","first-page":"8804","DOI":"10.1021\/jf061722y","article-title":"Extractable amounts of trans-resveratrol in seed and berry skin in Vitis\u00a0evaluated at the germplasm level","volume":"54","author":"Li","year":"2006","journal-title":"J Agric Food Chem"},{"key":"2025032500383245600_bib61","doi-asserted-by":"publisher","first-page":"4606","DOI":"10.1128\/MCB.00723-13","article-title":"Protein inhibitor of activated STAT 1 (PIAS1) is identified as the SUMO E3 ligase of CCAAT\/enhancer-binding protein \u03b2 (C\/EBP\u03b2) during adipogenesis","volume":"33","author":"Liu","year":"2013","journal-title":"Mol Cell Biol"},{"key":"2025032500383245600_bib62","doi-asserted-by":"publisher","first-page":"21984","DOI":"10.1073\/pnas.0910040106","article-title":"Target identification using drug affinity responsive target stability (DARTS)","volume":"106","author":"Lomenick","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025032500383245600_bib63","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.pharmthera.2005.07.003","article-title":"Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents","volume":"109","author":"Lugnier","year":"2006","journal-title":"Pharmacol Ther"},{"key":"2025032500383245600_bib64","doi-asserted-by":"publisher","first-page":"7635","DOI":"10.1038\/s41598-021-86920-w","article-title":"Extracellular vesicles isolated from milk can improve gut barrier dysfunction induced by malnutrition","volume":"11","author":"Maghraby","year":"2021","journal-title":"Sci Rep"},{"key":"2025032500383245600_bib65","doi-asserted-by":"publisher","first-page":"e0239428","DOI":"10.1371\/journal.pone.0239428","article-title":"Acetic acid stimulates G-protein-coupled receptor GPR43 and induces intracellular calcium influx in L6 myotube cells","volume":"15","author":"Maruta","year":"2020","journal-title":"PLoS One"},{"key":"2025032500383245600_bib66","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1479-5876-12-43","article-title":"Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?","volume":"12","author":"Melnik","year":"2014","journal-title":"J Transl Med"},{"key":"2025032500383245600_bib67","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3181\/00379727-208-43830","article-title":"Estrogenic flavonoids: structural requirements for biological activity","volume":"208","author":"Miksicek","year":"1995","journal-title":"Exp Biol Med"},{"key":"2025032500383245600_bib68","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2174\/1874467215666220415131344","article-title":"Resveratrol augments doxorubicin and cisplatin chemotherapy: a novel therapeutic strategy","volume":"16","author":"Mirzaei","year":"2023","journal-title":"Curr Mol Pharmacol"},{"key":"2025032500383245600_bib69","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3177\/jnsv.60.122","article-title":"Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells","volume":"60","author":"Mitani","year":"2014","journal-title":"J Nutr Sci Vitaminol"},{"key":"2025032500383245600_bib70","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.bbrc.2019.11.165","article-title":"Intracellular cAMP contents regulate NAMPT expression via induction of C\/ebp\u03b2 in adipocytes","volume":"522","author":"Mitani","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"2025032500383245600_bib71","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1016\/j.bbamcr.2017.09.017","article-title":"Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein \u03b2 degradation by adenosine receptor A1","volume":"1864","author":"Mitani","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"2025032500383245600_bib72","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1016\/j.bmc.2003.11.035","article-title":"Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta","volume":"12","author":"Muthyala","year":"2004","journal-title":"Bioorg Med Chem"},{"key":"2025032500383245600_bib73","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s42004-024-01181-8","article-title":"Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries","volume":"7","author":"Nagasawa","year":"2024","journal-title":"Commun Chem"},{"key":"2025032500383245600_bib74","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3177\/jnsv.68.420","article-title":"25-Hydroxyvitamin D increases insulin-stimulated glucose uptake by enhancing adipocyte differentiation","volume":"68","author":"Nakashima","year":"2022","journal-title":"J Nutr Sci Vitaminol"},{"key":"2025032500383245600_bib75","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3945\/ajcn.112.035972","article-title":"Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women","volume":"96","author":"Nechuta","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"2025032500383245600_bib76","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.3945\/ajcn.112.047373","article-title":"Effect of cocoa and theobromine consumption on serum HDL-cholesterol concentrations: a randomized controlled trial","volume":"97","author":"Neufingerl","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"2025032500383245600_bib77","doi-asserted-by":"publisher","first-page":"491S","DOI":"10.1093\/ajcn\/88.2.491S","article-title":"From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health","volume":"88","author":"Norman","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"2025032500383245600_bib78","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jnutbio.2017.07.017","article-title":"Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor \u03b2 and increases skeletal muscle mass in young female mice","volume":"49","author":"Ogawa","year":"2017","journal-title":"J Nutr Biochem"},{"key":"2025032500383245600_bib79","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"2025032500383245600_bib80","doi-asserted-by":"publisher","first-page":"21246","DOI":"10.1038\/s41598-023-48525-3","article-title":"3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41","volume":"13","author":"Ohue-Kitano","year":"2023","journal-title":"Sci Rep"},{"key":"2025032500383245600_bib82","doi-asserted-by":"publisher","first-page":"105497","DOI":"10.1016\/j.jbc.2023.105497","article-title":"From membrane to nucleus: a three-wave hypothesis of cAMP signaling","volume":"300","author":"Pizzoni","year":"2024","journal-title":"J Biol Chem"},{"key":"2025032500383245600_bib83","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/ncb1283","article-title":"Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration","volume":"7","author":"Rajalingam","year":"2005","journal-title":"Nat Cell Biol"},{"key":"2025032500383245600_bib84","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1080\/10408398.2016.1263597","article-title":"Resveratrol as an anti-cancer agent: a review","volume":"58","author":"Rauf","year":"2018","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2025032500383245600_bib85","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1073\/pnas.77.1.285","article-title":"Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes","volume":"77","author":"Reed","year":"1980","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025032500383245600_bib86","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1128\/MCB.20.3.1008-1020.2000","article-title":"CREB activation induces adipogenesis in 3T3-L1 cells","volume":"20","author":"Reusch","year":"2000","journal-title":"Mol Cell Biol"},{"key":"2025032500383245600_bib87","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1007\/s00198-020-05476-z","article-title":"Effects of isoflavone interventions on bone mineral density in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials","volume":"31","author":"Sansai","year":"2020","journal-title":"Osteoporos Int"},{"key":"2025032500383245600_bib88","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/jbmr.2927","article-title":"Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial","volume":"32","author":"Sathyapalan","year":"2017","journal-title":"J Bone Miner Res"},{"key":"2025032500383245600_bib89","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1002\/mnfr.201200593","article-title":"A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K","volume":"57","author":"Seo","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"2025032500383245600_bib90","doi-asserted-by":"publisher","first-page":"3577","DOI":"10.1093\/jn\/132.12.3577","article-title":"The clinical importance of the metabolite equol\u2014a clue to the effectiveness of soy and its isoflavones","volume":"132","author":"Setchell","year":"2002","journal-title":"J Nutr"},{"key":"2025032500383245600_bib92","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1093\/ajcn\/81.5.1072","article-title":"S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora","volume":"81","author":"Setchell","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"2025032500383245600_bib91","doi-asserted-by":"publisher","first-page":"1355S","DOI":"10.3945\/jn.109.119776","article-title":"Equol: history, chemistry, and formation","volume":"140","author":"Setchell","year":"2010","journal-title":"J Nutr"},{"key":"2025032500383245600_bib93","doi-asserted-by":"publisher","first-page":"8431","DOI":"10.1039\/D3FO00555K","article-title":"Theobromine supplementation in combination with a low-calorie diet improves cardiovascular risk factors in overweight and obese subjects with metabolic syndrome: a randomized controlled trial","volume":"14","author":"Sharifi-Zahabi","year":"2023","journal-title":"Food Funct"},{"key":"2025032500383245600_bib94","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1001\/jama.2009.1783","article-title":"Soy food intake and breast cancer survival","volume":"302","author":"Shu","year":"2009","journal-title":"JAMA"},{"key":"2025032500383245600_bib95","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1002\/med.21565","article-title":"Health benefits of resveratrol: evidence from clinical studies","volume":"39","author":"Singh","year":"2019","journal-title":"Med Res Rev"},{"key":"2025032500383245600_bib96","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1080\/01635581.2023.2279220","article-title":"Dietary isoflavone intake and breast cancer prognosis: a prospective analysis and meta-analysis","volume":"76","author":"Song","year":"2024","journal-title":"Nutr Cancer"},{"key":"2025032500383245600_bib97","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.1210\/jc.2013-1180","article-title":"Genistein in the metabolic syndrome: results of a randomized clinical trial","volume":"98","author":"Squadrito","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2025032500383245600_bib98","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1159\/000507626","article-title":"Milk exosomes prevent intestinal inflammation in a genetic mouse model of ulcerative colitis: a pilot experiment","volume":"5","author":"Stremmel","year":"2020","journal-title":"Inflamm Intest Dis"},{"key":"2025032500383245600_bib99","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2174\/1874467215666220415131344","article-title":"\u00dcber Oryzanin, ein Bestandteil der Reiskleie und sein physiologische\u00a0Bedeutung","volume":"43","author":"Suzuki","year":"1912","journal-title":"Biochem Z"},{"key":"2025032500383245600_bib100","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jhep.2010.06.045","article-title":"Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells","volume":"54","author":"Tak","year":"2011","journal-title":"J Hepatol"},{"key":"2025032500383245600_bib101","doi-asserted-by":"publisher","first-page":"e0120865","DOI":"10.1371\/journal.pone.0120865","article-title":"The 4\u2032-hydroxyl group of resveratrol is functionally important for direct activation of PPAR\u03b1","volume":"10","author":"Takizawa","year":"2015","journal-title":"PLoS One"},{"key":"2025032500383245600_bib102","doi-asserted-by":"publisher","first-page":"108898","DOI":"10.1016\/j.jnutbio.2021.108898","article-title":"Theobromine enhances the conversion of white adipocytes into beige adipocytes in a ppar\u03b3 activation-dependent manner","volume":"100","author":"Tanaka","year":"2022","journal-title":"J Nutr Biochem"},{"key":"2025032500383245600_bib103","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1093\/jn\/nxac130","article-title":"(S)-equol is more effective than (R)-equol in inhibiting osteoclast formation and enhancing osteoclast apoptosis, and reduces estrogen deficiency-induced bone loss in mice","volume":"152","author":"Tanaka","year":"2022","journal-title":"J Nutr"},{"key":"2025032500383245600_bib104","doi-asserted-by":"publisher","first-page":"e2211","DOI":"10.1038\/cddis.2016.114","article-title":"Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer","volume":"7","author":"Taniguchi","year":"2016","journal-title":"Cell Death Dis"},{"key":"2025032500383245600_bib106","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1097\/gme.0b013e3181f85aa7","article-title":"Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized, placebo-controlled trial","volume":"18","author":"Tousen","year":"2011","journal-title":"Menopause"},{"key":"2025032500383245600_bib107","doi-asserted-by":"publisher","first-page":"13324","DOI":"10.1073\/pnas.231474698","article-title":"Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects","volume":"98","author":"Van\u00a0Cromphaut","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025032500383245600_bib121_554_184225","doi-asserted-by":"publisher","first-page":"6095","DOI":"10.1111\/febs.15583","article-title":"New insights into the activities and toxicities of the old anticancer drug doxorubicin","volume":"288","author":"van\u00a0der\u00a0Zanden","year":"2021","journal-title":"FEBS J"},{"key":"2025032500383245600_bib108","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1089\/ars.2007.1628","article-title":"Detection and characterization of tumor hypoxia using pO2 histography","volume":"9","author":"Vaupel","year":"2007","journal-title":"Antioxid Redox Signal"},{"key":"2025032500383245600_bib109","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s13318-012-0112-y","article-title":"Isoflavones: estrogenic activity, biological effect and bioavailability","volume":"38","author":"Vitale","year":"2013","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"2025032500383245600_bib110","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1039\/C4FO01119H","article-title":"Food derived microRNAs","volume":"6","author":"Wagner","year":"2015","journal-title":"Food Funct."},{"key":"2025032500383245600_bib111","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nrd.2018.93","article-title":"Principles for targeting RNA with drug-like small molecules","volume":"17","author":"Warner","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"2025032500383245600_bib112","doi-asserted-by":"publisher","first-page":"109433","DOI":"10.1016\/j.jnutbio.2023.109433","article-title":"Genistein enhances NAD+ biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes","volume":"121","author":"Watanabe","year":"2023","journal-title":"J Nutr Biochem"},{"key":"2025032500383245600_bib113","doi-asserted-by":"publisher","first-page":"4128","DOI":"10.1128\/MCB.16.8.4128","article-title":"Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C\/EBPbeta, C\/EBPdelta, and glucocorticoids","volume":"16","author":"Wu","year":"1996","journal-title":"Mol Cell Biol"},{"key":"2025032500383245600_bib114","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1016\/j.bbadis.2015.06.017","article-title":"FNDC5 overexpression and irisin ameliorate glucose\/lipid metabolic derangements and enhance lipolysis in obesity","volume":"1852","author":"Xiong","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"2025032500383245600_bib115","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41586-018-0049-7","article-title":"Genetic identification of leptin neural circuits in energy and glucose homeostases","volume":"556","author":"Xu","year":"2018","journal-title":"Nature"},{"key":"2025032500383245600_bib116","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1210\/en.2012-1542","article-title":"Vitamin D receptor in osteoblasts is a negative regulator of bone mass control","volume":"154","author":"Yamamoto","year":"2013","journal-title":"Endocrinology"},{"key":"2025032500383245600_bib118","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1016\/j.advnut.2023.09.008","article-title":"Effect of isoflavones on blood lipid alterations in postmenopausal females: a systematic review and meta-analysis of randomized trials","volume":"14","author":"Yang","year":"2023","journal-title":"Adv Nutr"},{"key":"2025032500383245600_bib119","doi-asserted-by":"publisher","first-page":"109648","DOI":"10.1016\/j.jnutbio.2024.109648","article-title":"EPA and DHA differentially improve insulin resistance by reducing adipose tissue inflammation-targeting GPR120\/ppar\u03b3 pathway","volume":"130","author":"Yang","year":"2024","journal-title":"J Nutr Biochem"},{"key":"2025032500383245600_bib120","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s00394-006-0602-2","article-title":"Soy isoflavones attenuate bone loss in early postmenopausal Chinese women: a single-blind randomized, placebo-controlled trial","volume":"45","author":"Ye","year":"2006","journal-title":"Eur J Nutr"},{"key":"2025032500383245600_bib122","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.cmet.2017.11.002","article-title":"NAD+ intermediates: the biology and therapeutic potential of NMN and NR","volume":"27","author":"Yoshino","year":"2018","journal-title":"Cell Metab"},{"key":"2025032500383245600_bib123","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.cmet.2011.08.014","article-title":"Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice","volume":"14","author":"Yoshino","year":"2011","journal-title":"Cell Metab"},{"key":"2025032500383245600_bib125","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/advances\/nmy127","article-title":"Dietary microRNA-a novel functional component of food","volume":"10","author":"Zhang","year":"2019","journal-title":"Adv Nutr"},{"key":"2025032500383245600_bib126","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/cr.2011.158","article-title":"Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA","volume":"22","author":"Zhang","year":"2012","journal-title":"Cell Res"}],"container-title":["Bioscience, Biotechnology, and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bbb\/advance-article-pdf\/doi\/10.1093\/bbb\/zbaf003\/61430164\/zbaf003.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bbb\/article-pdf\/89\/4\/523\/61430164\/zbaf003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bbb\/article-pdf\/89\/4\/523\/61430164\/zbaf003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T05:19:47Z","timestamp":1743225587000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bbb\/article\/89\/4\/523\/7953333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":121,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,1,13]]},"published-print":{"date-parts":[[2025,3,24]]}},"URL":"https:\/\/doi.org\/10.1093\/bbb\/zbaf003","relation":{},"ISSN":["1347-6947"],"issn-type":[{"value":"1347-6947","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,1,13]]}}}