{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:16:10Z","timestamp":1782861370771,"version":"3.54.5"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Center for Geriatrics and Gerontology of Japan","award":["21-2"],"award-info":[{"award-number":["21-2"]}]},{"name":"National Center for Geriatrics and Gerontology of Japan","award":["24-9"],"award-info":[{"award-number":["24-9"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H03524"],"award-info":[{"award-number":["22H03524"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fuji Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Soy isoflavones are involved deeply in our diet as beneficial to health. It is known to have anti-inflammatory and antioxidant effects and also to be effective in alleviating various lifestyle diseases, as well as the maintenance of endocrine function, especially with age-related diseases such as osteoporosis. Here we investigated the impact of age-dependent changes with the intestinal microbiota in physiologically aged C57BL\/6\u00a0N by free drinking water with soluble soybean-derived isoflavone glycosides (SIFs) for 4 weeks. Consequently, Akkermansia muciniphila (A. muciniphila) species represented an age-dependent increase with SIF treatment, subsequently, generally age-dependent decreased goblet cells are retained in the large intestine. These results invoke that SIF plays a beneficial role in intestinal barrier function to maintain large intestine homeostasis. Interestingly, we also revealed that SIF had an alleviating effect on age-dependent bone loss. Taken together, SIF has a fruitful effect on the intestinal environment and the maintenance of homeostasis in physiological aging.<\/jats:p>","DOI":"10.1093\/bbb\/zbaf032","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T02:43:51Z","timestamp":1742265831000},"page":"884-893","source":"Crossref","is-referenced-by-count":2,"title":["Impact of a water-soluble soy extract on inflammation and gut microbiota in physiologically aged mice"],"prefix":"10.1093","volume":"89","author":[{"given":"Kenji","family":"Watanabe","sequence":"first","affiliation":[{"name":"Geroscience Research Center, Research Institute, National Center for Geriatrics and Gerontology , Aichi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Kamei","sequence":"additional","affiliation":[{"name":"Geroscience Research Center, Research Institute, National Center for Geriatrics and Gerontology , Aichi 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