{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:48:59Z","timestamp":1776725339426,"version":"3.51.2"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K17980"],"award-info":[{"award-number":["18K17980"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The relationship between obesity-induced leptin resistance and skin function remains unclear. In this study, we examined the effects of leptin signaling on collagen production in mouse skin. Mice were divided into three groups: control diet, high-fat diet, and switching diet (from the high-fat diet to the control diet). We measured the expression of leptin signaling-related genes and type I tropocollagen levels in the skin. In an additional experiment, leptin was administered to leptin-deficient ob\/ob mice to examine the direct effect of leptin signaling on type I collagen synthesis in the skin. Type I tropocollagen levels and Ob-Rb gene expression were decreased in the high-fat diet group. These abnormalities were reversed by the switching diet. We also observed that type I tropocollagen levels were decreased in ob\/ob mice, but this abnormality was reversed by leptin administration. It is likely that leptin will help to improve obesity-induced skin fragility.<\/jats:p>","DOI":"10.1093\/bbb\/zbaf171","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T12:32:04Z","timestamp":1763382724000},"page":"234-242","source":"Crossref","is-referenced-by-count":2,"title":["Obesity-induced leptin resistance is directly involved in skin fragility by decreasing type I collagen synthesis"],"prefix":"10.1093","volume":"90","author":[{"given":"Takumi","family":"Yamane","sequence":"first","affiliation":[{"name":"Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science and Food Safety, , Setagaya-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Tsukahara","sequence":"additional","affiliation":[{"name":"Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science and Food Safety, , Setagaya-ku, Tokyo 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