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To identify natural RCS scavengers, we examined 80% ethanol extracts from 46 angiosperm species for Acr-trapping activity using an HPLC-based assay. Strong activities were observed in several taxa, including garlic, spinach, avocado, broccoli, and lotus. In garlic, the active metabolite was identified as S-allyl-L-cysteine sulfoxide (alliin), a characteristic Allium amino acid. Alliin and its S-(1E)-propenyl and S-methyl derivatives (isoalliin and methiin, respectively) trapped up to two Acr molecules at the amino group and exhibited higher activities than known scavengers such as carnosine and epigallocatechin gallate. These findings highlight S-alk(en)yl-L-cysteine sulfoxides as potent secondary antioxidants and suggest that structurally diverse RCS scavengers remain to be discovered in plants.<\/jats:p>","DOI":"10.1093\/bbb\/zbaf172","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T13:24:48Z","timestamp":1763731488000},"page":"195-205","source":"Crossref","is-referenced-by-count":1,"title":["<i>S<\/i>\n                    -alk(en)yl-cysteine sulfoxides in\n                    <i>Allium<\/i>\n                    species are excellent acrolein scavengers: implications for secondary antioxidants in plants"],"prefix":"10.1093","volume":"90","author":[{"given":"Ayako","family":"Hada","sequence":"first","affiliation":[{"name":"Graduate School of Sciences and Technology for Innovation, Yamaguchi University , Yoshida 1677-1, Yamaguchi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Yamaguchi University , Yoshida 1677-1, Yamaguchi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsumi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Yamaguchi University , Yoshida 1677-1, Yamaguchi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4875-5176","authenticated-orcid":false,"given":"Kenji","family":"Matsui","sequence":"additional","affiliation":[{"name":"Graduate School of Sciences and Technology for Innovation, Yamaguchi University , Yoshida 1677-1, Yamaguchi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumasa","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Advanced Technology Institute, Yamaguchi University , Yoshida 1677-1, Yamaguchi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Shibata","sequence":"additional","affiliation":[{"name":"Kazusa DNA Research Institute , 2-6-7 Kazusa-kamatari, Kisarazu, Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5030-8845","authenticated-orcid":false,"given":"Jun\u2019ichi","family":"Mano","sequence":"additional","affiliation":[{"name":"Graduate School of Sciences and Technology for Innovation, Yamaguchi University , Yoshida 1677-1, Yamaguchi ,","place":["Japan"]},{"name":"Science Research Center, Organization for Research Initiatives, Yamaguchi University , Yoshida 1677-1, Yamaguchi ,","place":["Japan"]},{"name":"The United Graduate School of Agricultural Science, Tottori University , Tottori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"key":"2026012403063911600_bib1","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S0006-291X(02)02545-7","article-title":"Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?","volume":"298","author":"Aldini","year":"2002","journal-title":"Biochem. 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