{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T15:37:40Z","timestamp":1774021060183,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 108-2320-B-030-003-"],"award-info":[{"award-number":["NSTC 108-2320-B-030-003-"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013784","name":"Fu Jen Catholic University","doi-asserted-by":"publisher","award":["A0109007"],"award-info":[{"award-number":["A0109007"]}],"id":[{"id":"10.13039\/501100013784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hyperglycemia activates the polyol pathway, producing fructose, which promotes glycation and denatures \u03b1-crystallin, ultimately leading to diabetic cataracts. This study compared the antiglycation effects of SMR and SBN, using a fructose-induced human \u03b1A-crystallin glycation model. Through fluorescence analysis, SDS-PAGE, and Western blotting methods, we found that glycation caused \u03b1A-crystallin to form fluorescent advanced glycation end products (AGEs), cross-linking AGEs, and N\u03b5-carboxymethyllysine (CML). Results show that SMR (&amp;gt; 20\u00a0\u03bcg\/mL) and SBN (&amp;gt; 100\u00a0\u03bcg\/mL) effectively inhibited cross-linking AGEs and CML formation. At concentrations above 4\u00a0\u03bcg\/mL, both significantly reduced fluorescent AGEs, with SMR showing 91.0\u00a0\u00b1\u00a00.8% inhibition and SBN 81.1\u00a0\u00b1\u00a01.7% at 100\u00a0\u03bcg\/mL. SMR also outperformed aminoguanidine hydrochloride in reducing carbonyl content at 500\u00a0\u03bcg\/mL. Therefore, SMR exhibited stronger antiglycation and antioxidation properties than SBN, showing potential as a natural health product to prevent diabetic cataract formation.<\/jats:p>","DOI":"10.1093\/bbb\/zbag005","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:42:38Z","timestamp":1767876158000},"page":"543-553","source":"Crossref","is-referenced-by-count":0,"title":["Superior antiglycation efficacy of silymarin from\n                    <i>Silybum marianum<\/i>\n                    in human \u03b1A-crystallin: Implications for diabetic cataract prevention"],"prefix":"10.1093","volume":"90","author":[{"given":"Yen-Ju","family":"Yang","sequence":"first","affiliation":[{"name":"Fu Jen Catholic University Department of Food Science, , New Taipei City 242062 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ping","family":"Yu","sequence":"additional","affiliation":[{"name":"Chinese Culture University Department of Nutrition and Health Sciences, , Taipei 11114 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan-Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Chinese Culture University Department of Horticulture and Biotechnology, , Taipei 11114 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Ping","family":"Lu","sequence":"additional","affiliation":[{"name":"Fu Jen Catholic University Department of Food Science, , New Taipei City 242062 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"2026032010320863400_bib1","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1002\/ptr.6171","article-title":"Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases","volume":"32","author":"Abenavoli","year":"2018","journal-title":"Phytother Res"},{"key":"2026032010320863400_bib2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s11010-007-9685-1","article-title":"Role of the specifically targeted lysine residues in the glycation dependent loss of chaperone activity of alpha A- and alpha B-crystallins","volume":"310","author":"Abraham","year":"2008","journal-title":"Mol Cell Biochem"},{"key":"2026032010320863400_bib3","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/1472-6882-14-130","article-title":"Mesona Chinensis benth extract prevents AGE formation and protein oxidation against fructose-induced protein glycation in vitro","volume":"14","author":"Adisakwattana","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"2026032010320863400_bib4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.diabres.2004.09.004","article-title":"Advanced glycation endproducts\u2014role in pathology of diabetic complications","volume":"67","author":"Ahmed","year":"2005","journal-title":"Diabetes Res Clin Pract"},{"key":"2026032010320863400_bib5","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.3390\/molecules22111942","article-title":"Silybin, a major bioactive component of milk thistle (Silybum marianum L. 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