{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:07:20Z","timestamp":1779268040752,"version":"3.51.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100015956","name":"Key Research and Development Program of Guangdong Province","doi-asserted-by":"publisher","award":["2023B0202030002"],"award-info":[{"award-number":["2023B0202030002"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Key Research and Development Program of Guangdong Province","doi-asserted-by":"publisher","award":["2021B0707010002"],"award-info":[{"award-number":["2021B0707010002"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Development Project of Key Laboratory of Functional Food of Ministry of Agriculture and Rural Areas"},{"name":"Key Laboratory of Agricultural Products Processing of Guangdong Province","award":["202401"],"award-info":[{"award-number":["202401"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type \u2161 diabetes and hypertension often coexist, affecting each other. Suppressing dipeptidyl peptidase-4 (DPP-\u2163) and angiotensin-I-converting enzyme (ACE) activity is crucial for managing these conditions. Lentinula edodes-stem protein, rich in hydrophobic amino acids, has potential for creating DPP-\u2163 and ACE inhibitory peptides. This study used this protein, combined with databases, to derive peptides that exhibit dual inhibition of DPP-\u2163 and ACE activity via enzymatic hydrolysis by Bacillus subtilis protease. The most active fraction (F1-2) had IC50 values of 0.0910\u00a0mg\/mL (DPP-\u2163) and 0.0189\u00a0mg\/mL (ACE). Following the sequencing of fraction F1-2, screening, and solid-phase synthesis, three novel peptides (EW-1, WR-2, and LP-3) exhibiting\u00a0&amp;gt;60% inhibition of both DPP-\u2163 and ACE at 1\u00a0mg\/mL. These peptides showed no significant toxicity to Caco-2 cells, indicating safety. These findings suggest that peptides derived from the stem of Lentinula edodes are promising candidates for health products targeting type \u2161 diabetes and hypertension.<\/jats:p>","DOI":"10.1093\/bbb\/zbag026","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T12:31:00Z","timestamp":1770640260000},"page":"791-803","source":"Crossref","is-referenced-by-count":0,"title":["Excavation of\n                    <i>Lentinula edodes<\/i>\n                    -stem-derived peptides doubly inhibiting DPP-IV and ACE activity"],"prefix":"10.1093","volume":"90","author":[{"given":"Qiulan","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering, South China University of Technology , Guangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Kang","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, South China University of Technology , Guangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haosu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, South China University of Technology , Guangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lega","family":"Tu","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, South China University of Technology , Guangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanshan","family":"Yu","sequence":"additional","affiliation":[{"name":"Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences\/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs\/Guangdong Key Laboratory of Agricultural Products Processing , Guangzhou 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