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In this study, we investigated the immunological significance of BTN1A1 in gastrointestinal epithelial cells. The human ectodomain of BTN1A1 expressed as a soluble Fc fusion protein (ectoBTN-Fc) was added to HT29-MTX-E12 cells as a model for gastrointestinal epithelial cells. In the absence of tumor necrosis factor (TNF)-\u03b1, it significantly promoted MUC5AC production via a weak activation of NF-\u03baB signal transduction pathway. In contrast, prior incubation with ectoBTN-Fc inhibited TNF-\u03b1-provoked-IL-8 secretion by suppressing the phosphorylation of NF-\u03baB p65. Binding analyses demonstrated that ectoBTN-Fc likely binds to HT29-MTX-E12 cells, followed by its endocytosis. These results suggest a dual-faceted regulatory function of BTN1A1. It reinforces intestinal mucosal barrier function under basal conditions, while it may endow a prophylactic effect alleviating strong inflammatory stimulation.<\/jats:p>","DOI":"10.1093\/bbb\/zbag072","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:49:25Z","timestamp":1779450565000},"page":"1007-1018","source":"Crossref","is-referenced-by-count":0,"title":["Dual-faceted regulation by butyrophilin 1A1 to produce MUC5AC and IL-8 from human colonic cell line HT29-MTX-E12"],"prefix":"10.1093","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7581-3091","authenticated-orcid":false,"given":"Minori","family":"Ishida","sequence":"first","affiliation":[{"name":"Laboratory of Bioengineering, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University , Kyoto 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