{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:00:43Z","timestamp":1784800843795,"version":"3.55.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["18KK0430"],"award-info":[{"award-number":["18KK0430"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Periodontal disease is a major oral infectious condition that leads to the degradation of alveolar bone and subsequent tooth loss. Porphyromonas gingivalis, a keystone pathogen in periodontitis, plays a critical role in disease initiation and progression. In a previous study, we demonstrated the anti-P. gingivalis activity of epimedokoreanin B, a prenylated flavonoid derived from Epimedium species. However, its in vivo efficacy against periodontitis remains unclear. Oral administration of epimedokoreanin B attenuated P. gingivalis-induced alveolar bone resorption in murine periodontitis models and suppressed infection-induced antibody production. Furthermore, epimedokoreanin B compromised bacterial membrane integrity and virulent gene expressions. In this preclinical study, in vitro and in vivo analyses indicate that epimedokoreanin B suppressed both bacterial viability and virulence, thereby attenuating alveolar bone loss caused by periodontitis. These findings suggest that epimedokoreanin B is a promising candidate for the development of novel therapeutics targeting periodontal pathogens.<\/jats:p>","DOI":"10.1093\/bbb\/zbag075","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:45:00Z","timestamp":1779882300000},"page":"1064-1071","source":"Crossref","is-referenced-by-count":0,"title":["Targeting\n                    <i>Porphyromonas gingivalis<\/i>\n                    virulence and viability with epimedokoreanin B prevents alveolar bone destruction\n                    <i>in vivo<\/i>"],"prefix":"10.1093","volume":"90","author":[{"given":"Toru","family":"Kariu","sequence":"first","affiliation":[{"name":"Department of Life Science, Shokei University , Chuo-ku, Kumamoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Sojo University , 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