{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:26:18Z","timestamp":1787567178613,"version":"build-2736575974"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26K18463"],"award-info":[{"award-number":["26K18463"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K15502"],"award-info":[{"award-number":["23K15502"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26K08670"],"award-info":[{"award-number":["26K08670"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vitamin D (VD) and Wnt signaling both play important roles in bone metabolism and are targeted in osteoporosis therapy. Combination treatment with VD derivatives and antisclerostin antibodies that activate Wnt signaling improves clinical outcomes, although the molecular basis of this cooperative effect remains unclear. Because \u03b2-catenin functions as a transcriptional co-regulator in canonical Wnt signaling, we examined whether \u03b2-catenin modulates vitamin D receptor (VDR)-mediated transcription. Reporter assays were performed in Saos-2 osteoblastic cells using VD response element and TCF\/LEF-responsive reporters. Activation of Wnt signaling by CHIR99021 or expression of constitutively active \u03b2-catenin did not enhance VDR transcriptional activity but modestly suppressed VD-induced transcription. Similar results were obtained in HCT116 and COS-1 cells. These findings indicate that VDR and Wnt\/\u03b2-catenin signalings are not cross-talked at the transcriptional level.<\/jats:p>","DOI":"10.1093\/bbb\/zbag084","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:36:24Z","timestamp":1781004984000},"page":"1182-1186","source":"Crossref","is-referenced-by-count":0,"title":["\u03b2-catenin does not co-activate vitamin D receptor-mediated transcription in osteoblastic and nonosteoblastic cells"],"prefix":"10.1093","volume":"90","author":[{"given":"Tram Thi-Ngoc","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Iryo Sosei University , Iino, Chuo-dai, Iwaki, Fukushima ,","place":["Japan"]},{"name":"Research Institute of Innovative Medicine, Tokiwa Foundation , Iwaki, Fukushima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Kanemoto","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Iryo Sosei University , Iino, Chuo-dai, Iwaki, Fukushima ,","place":["Japan"]},{"name":"Research Institute of Innovative Medicine, Tokiwa Foundation , Iwaki, Fukushima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Iryo Sosei University , Iino, Chuo-dai, Iwaki, Fukushima ,","place":["Japan"]},{"name":"Research Institute of Innovative Medicine, Tokiwa Foundation , Iwaki, Fukushima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Iryo Sosei University , Iino, Chuo-dai, Iwaki, Fukushima ,","place":["Japan"]},{"name":"Research Institute of Innovative Medicine, Tokiwa Foundation , Iwaki, Fukushima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Iryo Sosei University , Iino, Chuo-dai, Iwaki, Fukushima ,","place":["Japan"]},{"name":"Research Institute of Innovative Medicine, Tokiwa Foundation , Iwaki, Fukushima ,","place":["Japan"]},{"name":"School of Medicine, Fukushima Medical University , Fukushima, Fukushima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5564-1695","authenticated-orcid":false,"given":"Shigeaki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Iryo Sosei University , Iino, Chuo-dai, Iwaki, Fukushima ,","place":["Japan"]},{"name":"Research Institute of Innovative Medicine, Tokiwa Foundation , Iwaki, Fukushima ,","place":["Japan"]},{"name":"School of Medicine, Fukushima Medical University , Fukushima, Fukushima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"2026082404520403500_bib1","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1210\/er.2018-00126","article-title":"Skeletal and extraskeletal actions of vitamin d: current evidence and outstanding questions","volume":"40","author":"Bouillon","year":"2019","journal-title":"Endocr Rev"},{"key":"2026082404520403500_bib2","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.3390\/nu14061291","article-title":"Rapid nontranscriptional effects of calcifediol and calcitriol","volume":"14","author":"Donati","year":"2022","journal-title":"Nutrients"},{"key":"2026082404520403500_bib3","doi-asserted-by":"publisher","first-page":"e0295288","DOI":"10.1371\/journal.pone.0295288","article-title":"Differential gene regulation by a synthetic vitamin D receptor ligand and active vitamin D in human cells","volume":"18","author":"Iwaki","year":"2023","journal-title":"PLoS One"},{"key":"2026082404520403500_bib4","doi-asserted-by":"publisher","first-page":"BSR20220321","DOI":"10.1042\/BSR20220321","article-title":"A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus","volume":"42","author":"Kanemoto","year":"2022","journal-title":"Biosci Rep"},{"key":"2026082404520403500_bib5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev Cell"},{"key":"2026082404520403500_bib6","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.bone.2011.07.011","article-title":"A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures\u2013a randomized, active comparator, double-blind study","volume":"49","author":"Matsumoto","year":"2011","journal-title":"Bone"},{"key":"2026082404520403500_bib7","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1007\/s00774-020-01091-4","article-title":"Eldecalcitol is superior to alfacalcidol in maintaining bone mineral density in glucocorticoid-induced osteoporosis patients (e-GLORIA)","volume":"38","author":"Matsumoto","year":"2020","journal-title":"J Bone Miner Metab"},{"key":"2026082404520403500_bib8","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.3390\/ijms27052396","article-title":"Vitamin D receptor signaling and ligand modulation: molecular mechanisms and therapeutic implications","volume":"27","author":"Nguyen","year":"2026","journal-title":"Int J Mol Sci"},{"key":"2026082404520403500_bib9","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u03b2-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"2026082404520403500_bib10","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1056\/NEJMoa1708322","article-title":"Romosozumab or alendronate for fracture prevention in women with osteoporosis","volume":"377","author":"Saag","year":"2017","journal-title":"N Engl J Med"},{"key":"2026082404520403500_bib11","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1210\/clinem\/dgaa048","article-title":"Pharmacological management of osteoporosis in postmenopausal women: an endocrine society guideline update","volume":"105","author":"Shoback","year":"2020","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Bioscience, Biotechnology, and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bbb\/advance-article-pdf\/doi\/10.1093\/bbb\/zbag084\/68501385\/zbag084.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bbb\/article-pdf\/90\/9\/1182\/68501385\/zbag084.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bbb\/article-pdf\/90\/9\/1182\/68501385\/zbag084.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:52:07Z","timestamp":1787561527000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bbb\/article\/90\/9\/1182\/8704721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":11,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,6,9]]},"published-print":{"date-parts":[[2026,8,24]]}},"URL":"https:\/\/doi.org\/10.1093\/bbb\/zbag084","relation":{},"ISSN":["1347-6947"],"issn-type":[{"value":"1347-6947","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,6,9]]}}}